Vinylation of Iododifluoromethylated Alcohols via a Light-Promoted Intramolecular Atom-Transfer Reaction

Abstract

A method for the synthesis of gem-difluorohomoallylic alcohols by the substitution of iodine in the iododifluoromethyl group by a vinyl fragment is described. The reaction proceeds via an intramolecular iodine atom transfer followed by β-elimination. The reaction is performed in the presence of an iridium photocatalyst, fac-Ir(ppy)₃, and triphenylphosphine under irradiation with light-emitting diodes.

Key words

organofluorine compounds - photocatalysis - silicon reagents­ - radical reaction - atom transfer

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