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Synthesis 2018; 50(04): 872-880
DOI: 10.1055/s-0036-1590947
DOI: 10.1055/s-0036-1590947
paper
Synthesis of Malononitrile-Substituted Diarylmethines via 1,6-Addition of Masked Acyl Cyanides to para-Quinone Methides
Further Information
Publication History
Received: 06 October 2017
Accepted: 09 October 2017
Publication Date:
23 November 2017 (online)
Abstract
An efficient method for the synthesis of malononitrile-substituted diarylmethines through 1,6-conjugate addition of para-quinone methides with masked acyl cyanide (MAC) reagents has been developed. Under mild conditions, the scalable reaction occurs in good to excellent yields providing a straightforward access to a series of malononitrile-substituted diarylmethines. The synthetic utility of this protocol has been demonstrated in the synthesis of bioactive compounds.
Key words
diarylmethines - 1,6-addition - masked acyl cyanides - para-quinone methides - malononitrile-substituted diarylmethinesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590947.
- Supporting Information
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