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Synthesis 2018; 50(05): 968-983
DOI: 10.1055/s-0036-1591877
short review
© Georg Thieme Verlag Stuttgart · New York

Perspective on FTY720, an Immunosuppressant

Sivaraman Balasubramaniam*
a   High Value Chemicals Group, Reliance Industries Limited, Ghansoli, Navi Mumbai 400701, India   Email: Sivaraman.balasubramaniam@ril.com
,
Ganapathy Subramanian Sankaran
b   University of Massachusetts Medical School, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical school, Worcester, MA-02464, USA
,
Sneh Sanjay Badle
a   High Value Chemicals Group, Reliance Industries Limited, Ghansoli, Navi Mumbai 400701, India   Email: Sivaraman.balasubramaniam@ril.com
› Author Affiliations
Further Information

Publication History

Received: 05 October 2017

Accepted after revision: 23 November 2017

Publication Date:
24 January 2018 (online)

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Dedicated to Professor Indrapal Singh Aidhen

Abstract

FTY720 {fingolimod hydrochloride, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride}, a novel immunosuppressant, was discovered by chemical modification based on the structure activity relationships of ISP-I (myriocin), a metabolite of the fungus Isaria­ sinclairii. This short perspective provides insights to the various strategies available in the literature for the synthesis of FTY720 and its analogues.

1 Introduction

2 Classification of Immunosuppressive Drugs

3 The Rise of FTY720

4 Different Synthetic Strategies for FTY720

5 Analogues of FTY720

6 Binding Studies of FTY720

7 Mode of Action

8 Conclusion

Key words

FTY720 - fingolimod hydrochloride - immunosuppressant - multiple sclerosis - medicinal chemistry - analogues
 

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