Eur J Pediatr Surg 2016; 26(05): 418-426
DOI: 10.1055/s-0036-1592197
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Surgical Management of the Undescended Testis: Recent Advances and Controversies

Jack S. Elder
1   Division of Pediatric Urology, Massachusetts General Hospital, Boston, Massachusetts, United States
› Author Affiliations
Further Information

Publication History

29 July 2016

02 August 2016

Publication Date:
15 September 2016 (online)

Abstract

Undescended testis (UDT) is the most common disorder of sexual development in boys and affects 3.5% of male newborns. Although approximately half of newborn UDTs descend spontaneously, some boys develop an ascending testis later in childhood. Recent guideline recommendations advocate orchiopexy by 18 months of age to maximize potential for fertility and perhaps reduce the risk for testicular carcinoma in the future. For palpable testes, a standard inguinal approach is appropriate. However, the prescrotal approach is often effective for low inguinal testes and reduces surgical time and patient discomfort with an equivalent success rate in boys with an ascending testis. Some advocate monitoring until adolescence to determine whether the testis will spontaneously descend into the scrotum, but data do not support this approach. Instead, prompt orchiopexy is recommended. In boys with a nonpalpable testis, approximately 50% are abdominal or high in the inguinal canal and 50% are atrophic, typically in the scrotum. Routine inguinal/scrotal ultrasound is not recommended, although in an older boy who is overweight, it is appropriate. If the patient has contralateral testicular hypertrophy, scrotal exploration is appropriate, and removal of the testicular remnant and contralateral scrotal orchiopexy to prevent future contralateral testicular torsion is recommended. In most cases, diagnostic laparoscopy is advised to determine whether the testis is abdominal. For the abdominal testis, there are numerous treatment options. If the testis is mobile or a peeping testis just distal to the internal inguinal ring, standard one-stage laparoscopic or open orchiopexy should be attempted using the Prentiss maneuver. If the testicular vessels are short or the testis is not mobile, a two-stage Fowler–Stephens orchiopexy is appropriate. The second stage can be performed laparoscopically or open. Another option is microvascular testicular autotransplantation, which is a technically demanding procedure. Surgical results of abdominal orchiopexy are highly variable, short term, and highly subjective. Prospective clinical trials with follow-up into adolescence and adulthood are necessary to assess the success of various surgical approaches.

 
  • References

  • 1 Hutson JM, Li R, Southwell BR, Newgreen D, Cousinery M. Regulation of testicular descent. Pediatr Surg Int 2015; 31 (4) 317-325
  • 2 Kolon TF, Herndon CD, Baker LA , et al; American Urological Assocation. Evaluation and treatment of cryptorchidism: AUA guideline. J Urol 2014; 192 (2) 337-345
  • 3 Penson D, Krishnaswami S, Jules A, McPheeters ML. Effectiveness of hormonal and surgical therapies for cryptorchidism: a systematic review. Pediatrics 2013; 131 (6) e1897-e1907
  • 4 Hadziselimovic F, Herzog B. The importance of both an early orchidopexy and germ cell maturation for fertility. Lancet 2001; 358 (9288) 1156-1157
  • 5 Park KH, Lee JH, Han JJ, Lee SD, Song SY. Histological evidences suggest recommending orchiopexy within the first year of life for children with unilateral inguinal cryptorchid testis. Int J Urol 2007; 14 (7) 616-621
  • 6 Tasian GE, Hittelman AB, Kim GE, DiSandro MJ, Baskin LS. Age at orchiopexy and testis palpability predict germ and Leydig cell loss: clinical predictors of adverse histological features of cryptorchidism. J Urol 2009; 182 (2) 704-709
  • 7 Rogers E, Teahan S, Gallagher H , et al. The role of orchiectomy in the management of postpubertal cryptorchidism. J Urol 1998; 159 (3) 851-854
  • 8 Kollin C, Karpe B, Hesser U, Granholm T, Ritzén EM. Surgical treatment of unilaterally undescended testes: testicular growth after randomization to orchiopexy at age 9 months or 3 years. J Urol 2007; 178 (4 Pt 2): 1589-1593 , discussion 1593
  • 9 Kollin C, Stukenborg JB, Nurmio M , et al. Boys with undescended testes: endocrine, volumetric and morphometric studies on testicular function before and after orchidopexy at nine months or three years of age. J Clin Endocrinol Metab 2012; 97 (12) 4588-4595
  • 10 Kollin C, Granholm T, Nordenskjöld A, Ritzén EM. Growth of spontaneously descended and surgically treated testes during early childhood. Pediatrics 2013; 131 (4) e1174-e1180
  • 11 Kim SO, Hwang EC, Hwang IS , et al. Testicular catch up growth: the impact of orchiopexy age. Urology 2011; 78 (4) 886-889
  • 12 Alpert PF, Klein RS. Spermatogenesis in the unilateral cryptorchid testis after orchiopexy. J Urol 1983; 129 (2) 301-302
  • 13 Smith EM, Dahms BB, Elder JS. Influence of vas deferens mobilization on rat fertility: implications regarding orchiopexy. J Urol 1993; 150 (2 Pt 2): 663-666
  • 14 Lekili M, Gümüş B, Kandiloglu AR, Işisag A, Müezzinoglu T, Büyüksu C. The effects of extensive vas mobilization on testicular histology during orchiopexy. Int Urol Nephrol 1998; 30 (2) 165-170
  • 15 Hoseinpour M, Memarzadeh M, Sadeqi A. Comparative investigation of two surgical techniques of orchiopexy in the post-operative recurrence rate and testicular size in children in clinical trial study. Adv Biomed Res 2015; 4: 171
  • 16 Ribeiro CT, De Souza DB, Costa WS, Pereira-Sampaio MA, Sampaio FJ. Effects of testicular transfixation on seminiferous tubule morphology and sperm parameters of prepubertal, pubertal, and adult rats. Theriogenology 2015; 84 (7) 1142-1148
  • 17 Kelalis P, Bunge R, Barkin M , et al. The timing of elective surgery on the genitalia of male children with particular reference to undescended testes and hypospadias. Pediatrics 1975; 56 (3) 479-483
  • 18 Hrivatakis G, Astfalk W, Schmidt A , et al. The timing of surgery for undescended testis - a retrospective multicenter analysis. Dtsch Arztebl Int 2014; 111 (39) 649-657
  • 19 Nilsson R, Omland H, Dahl AA, Johansen TE. Early outcome of orchiopexy and analysis of predictive factors: a retrospective study from 2001 to 2010 in a Norwegian regional hospital. Scand J Urol 2014; 48 (5) 474-481
  • 20 Springer A, Subramaniam R, Krall C, Fülöp G. Orchidopexy patterns in Austria from 1993 to 2009. J Pediatr Urol 2013; 9 (5) 535-541
  • 21 Hensel KO, Caspers T, Jenke AC, Schuler E, Wirth S. Operative management of cryptorchidism: guidelines and reality—a 10-year observational analysis of 3587 cases. BMC Pediatr 2015; 15: 116
  • 22 Agarwal PK, Diaz M, Elder JS. Retractile testis—is it really a normal variant?. J Urol 2006; 175 (4) 1496-1499
  • 23 Hack WW, Meijer RW, Van Der Voort-Doedens LM, Bos SD, De Kok ME. Previous testicular position in boys referred for an undescended testis: further explanation of the late orchidopexy enigma?. BJU Int 2003; 92 (3) 293-296
  • 24 Hack WW, Sijstermans K, van Dijk J, van der Voort-Doedens LM, de Kok ME, Hobbelt-Stoker MJ. Prevalence of acquired undescended testis in 6-year, 9-year and 13-year-old Dutch schoolboys. Arch Dis Child 2007; 92 (1) 17-20
  • 25 van der Plas EM, van Brakel J, Meij-de Vries A , et al. Acquired undescended testes and fertility potential: is orchiopexy at diagnosis better than awaiting spontaneous descent?. Andrology 2015; 3 (4) 677-684
  • 26 Niedzielski JK, Oszukowska E, Słowikowska-Hilczer J. Undescended testis - current trends and guidelines: a review of the literature. Arch Med Sci 2016; 12 (3) 667-677
  • 27 van Brakel J, Kranse R, de Muinck Keizer-Schrama SMPF , et al. Fertility potential in a cohort of 65 men with previously acquired undescended testes. J Pediatr Surg 2014; 49 (4) 599-605
  • 28 Thomas RJ, Holland AJA. Surgical approach to the palpable undescended testis. Pediatr Surg Int 2014; 30 (7) 707-713
  • 29 Docimo SG. The results of surgical therapy for cryptorchidism: a literature review and analysis. J Urol 1995; 154 (3) 1148-1152
  • 30 Taran I, Elder JS. Results of orchiopexy for the undescended testis. World J Urol 2006; 24 (3) 231-239
  • 31 Ein SH, Nasr A, Wales PW, Ein A. Testicular atrophy after attempted pediatric orchidopexy for true undescended testis. J Pediatr Surg 2014; 49 (2) 317-322
  • 32 McIntosh LA, Scrimgeour D, Youngson GG, Driver CP. The risk of failure after primary orchidopexy: an 18.  year review. J Pediatr Urol 2013; 9 (6 Pt A): 759-762
  • 33 Bianchi A, Squire BR. Transcrotal orchidopexy: orchidopexy. Pediatr Surg Int 1989; 4: 189-192
  • 34 Gordon M, Cervellione RM, Morabito A, Bianchi A. 20 years of transcrotal orchidopexy for undescended testis: results and outcomes. J Pediatr Urol 2010; 6 (5) 506-512
  • 35 Rodriguez LE, Kaplan GW. An experimental study of methods to produce intrascrotal testicular fixation. J Urol 1988; 139 (3) 565-567
  • 36 Ward JF, Cilento Jr BG, Kaplan GW, Velling TE, Puckett M, Stock J. The ultrasonic description of postpubertal testicles in men who have undergone prepubertal orchiopexy for cryptorchidism. J Urol 2000; 163 (5) 1448-1450
  • 37 Kozminski DJ, Kraft KH, Bloom DA. Orchiopexy without transparenchymal suturing: a 29-year experience. J Urol 2015; 194 (6) 1743-1747
  • 38 Dudley AG, Sweeney DD, Docimo SG. Orchiopexy after prior inguinal surgery: a distal approach. J Urol 2011; 185 (6) 2340-2343
  • 39 Karaman I, Karaman A, Erdoğan D, Çavuşoğlu YH. The transscrotal approach for recurrent and iatrogenic undescended testes. Eur J Pediatr Surg 2010; 20 (4) 267-269
  • 40 Lopes RI, Naoum NK, Chua ME, Canil T, Dos Santos J, Farhat WA. Outcome analysis of redo orchiopexy: scrotal vs inguinal. J Urol 2016; (e-pub ahead of print)
  • 41 Sfoungaris D, Mouravas V. A combined preperitoneal and inguinal approach for redo orchiopexy. J Pediatr Urol 2016; 12 (1) 43.e1-43.e6
  • 42 Wood HM, Elder JS. Cryptorchidism and testicular cancer: separating fact from fiction. J Urol 2009; 181 (2) 452-461
  • 43 Diamond DA, Caldamone AA, Elder JS. Prevalence of the vanishing testis in boys with a unilateral impalpable testis: is the side of presentation significant?. J Urol 1994; 152 (2 Pt 1): 502-503
  • 44 Elder JS. Ultrasonography is unnecessary in evaluating boys with a nonpalpable testis. Pediatrics 2002; 110 (4) 748-751
  • 45 Braga LH, Kim S, Farrokhyar F, Lorenzo AJ. Is there an optimal contralateral testicular cut-off size that predicts monorchism in boys with nonpalpable testicles?. J Pediatr Urol 2014; 10 (4) 693-698
  • 46 Hodhod A, Capolicchio JP, Jednak R, El-Sherbiny M. Testicular hypertrophy as a predictor for contralateral monorchism: retrospective review of prospectively recorded data. J Pediatr Urol 2016; 12 (1) 34.e1-34.e5
  • 47 Storm D, Redden T, Aguiar M, Wilkerson M, Jordan G, Sumfest J. Histologic evaluation of the testicular remnant associated with the vanishing testes syndrome: is surgical management necessary?. Urology 2007; 70 (6) 1204-1206
  • 48 Emir H, Ayik B, Eliçevik M , et al. Histological evaluation of the testicular nubbins in patients with nonpalpable testis: assessment of etiology and surgical approach. Pediatr Surg Int 2007; 23 (1) 41-44
  • 49 Prakash J, Dalela D, Goel A , et al. Testicular rerouting by modified Prentiss maneuver: usefulness in bilateral synchronous orchidopexy for high inguinal undescended testes. J Pediatr Surg 2014; 49 (8) 1311-1314
  • 50 Gheiler EL, Barthold JS, González R. Benefits of laparoscopy and the Jones technique for the nonpalpable testis. J Urol 1997; 158 (5) 1948-1951
  • 51 Bukowski TP, Wacksman J, Billmire DA, Lewis AG, Sheldon CA. Testicular autotransplantation: a 17-year review of an effective approach to the management of the intra-abdominal testis. J Urol 1995; 154 (2 Pt 1): 558-561
  • 52 Steinhardt GF, Kroovand RL, Perlmutter AD. Orchiopexy: planned 2-stage technique. J Urol 1985; 133 (3) 434-435
  • 53 Shehata S, Shalaby R, Ismail M, Abouheba M, Elrouby A. Staged laparoscopic traction-orchiopexy for intraabdominal testis (Shehata technique): stretching the limits for preservation of testicular vasculature. J Pediatr Surg 2016; 51 (2) 211-215
  • 54 Casanova NC, Johnson EK, Bowen DK , et al. Two-step Fowler-Stephens orchiopexy for intra-abdominal testes: a 28-year single institution experience. J Urol 2013; 190 (4) 1371-1376
  • 55 Dhanani NN, Cornelius D, Gunes A, Ritchey ML. Successful outpatient management of the nonpalpable intra-abdominal testis with staged Fowler-Stephens orchiopexy. J Urol 2004; 172 (6 Pt 1): 2399-2401