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Synthesis 2018; 50(14): 2761-2767
DOI: 10.1055/s-0037-1610137
DOI: 10.1055/s-0037-1610137
paper
Synthesis of Imidazo[1,5-a]quinolines via Metal-Free Oxidative Amination of sp3 C–H Bonds
We are grateful to the National Science Foundation of China (No. 21572117) and the State Key Laboratory of Natural and Biomimetic Drugs of Peking University (No. K20140208) for financial support of this research.Further Information
Publication History
Received: 08 March 2018
Accepted after revision: 07 April 2018
Publication Date:
29 May 2018 (online)
Abstract
A novel oxidative amination of sp3 C–H bonds was developed for the efficient synthesis of imidazo[1,5-a]quinolines from readily available α-amino acids and (2-azaaryl)methanes. This domino protocol, which was established in a TBAI-TBHP oxidation system, includes transition-metal-free decarboxylation and intramolecular cyclization. This method represented a new avenue for the synthesis of N-heterocycles using 2-methylquinolines as the synthon of quinoline-2-carbaldehydes.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610137.
- Supporting Information
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