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Nuklearmedizin 1981; 20(02): 72-75
DOI: 10.1055/s-0037-1620719
Originalarbeiten – Original Articles
Schattauer GmbH

The Effect of Carbimazole Following Radioiodine Therapy on Radiation Dose to the Thyroid

Die Wirkung von Carbimazol nach Radiojodtherapie auf die Strahlenbelastung der Schilddrüse
T.M.D. Gimlette
1   From the Department of Nuclear Medicine, Royal Liverpool Hospital, Liverpool, England
,
R. Kocak
1   From the Department of Nuclear Medicine, Royal Liverpool Hospital, Liverpool, England
,
R.G. Herbert
1   From the Department of Nuclear Medicine, Royal Liverpool Hospital, Liverpool, England
,
C.R. Squire
1   From the Department of Nuclear Medicine, Royal Liverpool Hospital, Liverpool, England
› Author Affiliations
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Publication History

Received: 22 December 1980

Publication Date:
10 January 2018 (online)

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Radioiodine in the thyroid gland after a therapy dose of 131I was measured serially in 7 patients without Carbimazole, and in 11 patients starting Carbimazole 60 mg daily fourteen days after the therapy dose. Effective half-life for radioiodine in the gland initially 5.53±1.08 days fell to 4.26±1.12 days (p < 0.01) during Carbimazole, and returned to 5.83±1.21 days (NS) after stopping the drug. The radiation dose to the thyroid from a given therapy dose of 131I followed by Carbimazole was calculated to be 97% of that without Carbimazole when the drug was started after 14 days, and 90% and 75% when the drug was started after 7 days and 1 day respectively.

Nach einer Therapiedosis von 131J wurde 14 Tage lang das Radiojod in der Schilddrüse bei 7 Patienten, die kein Carbimazol nahmen, und bei 11 Patienten, denen 60 mg Carbimazol pro Tag verabreicht wurden, laufend verfolgt. Während der Behandlung verminderte sich anfangs die effektive Halbwertzeit des Radiojods in der Schilddrüse von 5.53±1.08 auf 4.26±1.12 (p < 0.01) bei jenen Patienten, die Carbimazol genommen hatten, und kehrte wieder auf 5.83±1.21 (NS) zurück, nachdem das Medikament abgesetzt worden war. Die Strahlenbelastung der Schilddrüse nach einer gegebenen 131J-Therapiedosis betrug, wenn mit Carbimazol 14 Tage später begonnen worden war, 97% der Strahlenbelastung ohne Carbimazol, und 90% bzw. 75%, wenn mit der Carbimazolgabe 7 Tage bzw. 1 Tag nach der 131J-Therapie begonnen worden war.

 

  • References

  • 1 Crooks J, Buchanan W.W, Wayne E.J, Mac-donald E. Effect of pretreatment with methylthiouracil on results of 13II therapy. Brit. med. J 1960; 1: 151-154.
    CrossrefPubMedGoogle Scholar
  • 2 Goolden A. W. G, Frazer T. R. Treatment of thyrotoxicosis with low doses of radioactive iodine. Brit. med. J 1960; 2: 442-443.
    CrossrefGoogle Scholar
  • 3 Goolden A. W. G, Frazer T. R. Effect of pretreatment with Carbimazole in patients with thyrotoxicosis subsequently treated with radioactive iodine. Brit.med.J 1969; 2: 443-444.
    Google Scholar
  • 4 N.M./M.I.R.D. Pamphlet No. 11. Society of Nuclear Medicine. 1975
    PubMedGoogle Scholar
  • 5 Schafer R.B, Nutall F.Q. Acute changes in thyroid function in patients treated with radioactive iodine. Lancet 1975; 2: 635-637.
    PubMedGoogle Scholar
  • 6 Shapiro B, Rigby L, Britton K.E. The assessment of thyroid volume with single photon emission tomography. Nucl.Med.Comm l: 37-40. 1980;
    Google Scholar
  • 7 Steinbach J. J, Donoghue G.D, Goldman J.K. Simultaneous treatment of toxic diffuse goitre with I-131 and antithyroid drugs: a prospective study. J.nucl.Med 1979; 20: 1263-1267.
    PubMedGoogle Scholar
  • 8 Tamagna E.I, Levine G.A, Hershman J.M. Thyroid-hormone concentrations after radioiodine therapy for hyperthyroidism. J.nucl.Med 1979; 20: 387-391.
    PubMedGoogle Scholar
  • 9 Thyroid Radionuclide Uptake Measurements. Report of an International Atomic Energy Agency Panel. Int. J. appl. Radiat. Isot. 1972; 23: 305-313.
    CrossrefPubMedGoogle Scholar
  • 10 Vennart J, Minski M. Radiation doses from administered radionuclides. Brit. J. Radiol 1962; 35: 372-387.
    CrossrefPubMedGoogle Scholar
  • 11 Wolff J. Some factors that influence the release of iodine from the thyroid gland. Endocrinology 1951; 48: 284-297.
    CrossrefPubMedGoogle Scholar