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Nuklearmedizin 1974; 13(04): 330-340
DOI: 10.1055/s-0038-1624869
Originalarbeiten — Original Articles
Schattauer GmbH

Technetium-99m Polyphosphate Bone Image for Early Detection of Skeletal Metastasis

Correlation With Other Diagnostic ParametersTechnetium-99m-Polyphosphat-Knochenbilder für die Früherkennung von SkelettmetastasenKorrelation mit anderen diagnostischen Parametern
G. T. Krishnamurthy
1   Nuclear Medicine and Research Services, Veterans Administration Wadsworth Hospital Center,Los Angeles; and University of California at Los Angeles (UCLA) School of Medicine, Los Angeles
,
W. H. Blahd
1   Nuclear Medicine and Research Services, Veterans Administration Wadsworth Hospital Center,Los Angeles; and University of California at Los Angeles (UCLA) School of Medicine, Los Angeles
› Author Affiliations
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Publication History

Received:21 October 1974

Publication Date:
25 January 2018 (online)

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Summary

Technetium 99m-polyphosphate bone images are correlated with bone roentgenography, and serum calcium, phosphorus and alkaline phosphatase in 91 patients with suspected bone metastasis. Technetium polyphosphate bone images are the most sensitive and serum level of calcium and phosphorus are the least sensitive indicator of bone lesions. Bone roentgenography is not as sensitive as technetium polyphosphate images. Abnormal bone images with normal or abnormal bone roentenography associated with increased alkaline phosphatase in the absence of liver metastasis are highly suggestive of metastatic bone disease. Abnormal bone images adjoining the joints, associated with normal serum alkaline phosphatase and abnormal joint roentgenography suggest arthritis. It is recommended that technetium 99m-labelled phosphate bone images are considered to be the diagnostic procedure of choice to detect skeletal lesions. Polyphosphate bone images are highly sensitive, with the combination of elevated alkaline phosphatase they become relatively more specific for a metastatic bone disease.

Technetium-99m-Polyphosphat-Knochenbilder werden mit Knochen-Röntgenbildern, Serum-Calciumwerten, Serum-Phosphat und alkalischer Phosphatase bei 91 Patienten mit Verdacht auf Knochenmetastasen verglichen. Technetium-Polyphosphat-Knochenbilder sind der empfindlichste und Serum-Calcium- und Phosphorspiegel der unempfindlichste Indikator für das Vorhandensein von Knochenherde. Die Knochen-Röntgenaufnahme ist weniger empfindlich als die Technetium-Polyphosphat-Abbildung. Abnorme Knochenbilder bei normaler oder abnormaler Knochen-Röntgenaufnahme zusammen mit erhöhter alkalischer Phosphatase bei Abwesenheit von Lebermetastasen sind hochgradig verdächtig auf die Anwesenheit von metastatischen Knochenerkrankungen. Abnorme Knochenbilder in Nähe der Gelenke in Verbindung mit normalen Röntgenbildern sind verdächtig auf Arthritis. Es wird vorgeschlagen, Technetium-99m-Phosphat-Knochenbilder als die diagnostische Maßnahme der Wahl zur Entdeckung von Skelettveränderungen anzusehen. Polyphosphat-Knochenbilder sind hochempfindlich in der Kombination mit erhöhter alkalischer Phosphate und sind mehr spezifisch für eine metastatische Knochenerkrankung.

 

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