Nervenheilkunde 2011; 30(03): 164-168
DOI: 10.1055/s-0038-1627791
Psychoonkologie
Schattauer GmbH

Langzeitfolgen von Krebserkrankungen

Late effects of cancer
L. Goldbeck
1   Klinik für Kinderund Jugendpsychiatrie und Psychotherapie, Universitätsklinikum Ulm
,
J. U. Rüffer
2   Deutsche Fatigue Gesellschaft, Köln
› Author Affiliations
Further Information

Publication History

eingegangen am: 26 September 2010

angenommen am: 29 October 2010

Publication Date:
23 January 2018 (online)

Zusammenfassung

Gestiegene Überlebenschancen nach einer Krebserkrankung haben die Aufmerksamkeit auf krankheitsund behandlungsbedingte Spätfolgen gerichtet. Der Beitrag gibt eine Übersicht zu Ergebnissen katamnestischer Untersuchungen hinsichtlich kardialer, pulmonaler, neurologischer, neuropsychologischer, gonadaler, und psychosozialer Spätfolgen und geht auf das Risiko von sekundären Neoplasien und krebsassoziierter Fatigue ein. Um rechtzeitig klinisch relevante Spätfolgen zu identifizieren und die langfristige Lebensqualität durch indizierte Interventionen zu sichern, wird eine lebenslange Krebsnachsorge empfohlen. Die Berücksichtigung einer Krebsvorgeschichte ist für die hausärztliche und nervenärztliche Versorgung von Bedeutung.

Summary

With increased survival rates after cancer, attention shifts from mortality to long-term morbidity due to diseaseand treatment-related late effects. This review summarizes empirical results of cardiac, pulmonary, neurological, neuropsychological, gonadal, and psychosocial late effects and describes the risk of secondary malignant diseases and of cancer related fatigue. Life-long follow-up assessments are recommended to identify survivors needing specific interventions to maintain optimal quality of life. A history of cancer has to be taken into account among patients within primary care and mental health system.

 
  • Literatur

  • 1 LENT SOMA scales for all anatomic sites. Int J Radiat Oncol Biol Phys 1995; 31: 1049-91.
  • 2 Aaronson NK. et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993; 85: 365-76.
  • 3 Butler RW, Haser JK. Neurocognitive effects of treatment for childhood cancer. Mental Retardation and Developmental Disabilities Research Reviews 2006; 12: 184-91.
  • 4 Butler RW, Rizzi LP, Handwerger BA. Brief report: The assessment of posttraumatic stress disorder in pediatric cancer patients and survivors. J Pediatr Psychol 1996; 21: 499-504.
  • 5 Cardinale D, Sandri MT. Role of biomarkers in chemotherapy-induced cardiotoxicity. Prog Cardiovasc Dis 2010; 53: 121-9.
  • 6 Carver JR. et al. American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: cardiac and pulmonary late effects. J Clin Oncol 2007; 25: 3991.
  • 7 Cella D. The Functional Assessment of Cancer Therapy-Anemia (FACT-An) Scale: a new tool for the assessment of outcomes in cancer anemia and fatigue. Semin Hematol 1997; 34 (3 Suppl 2) 13-9.
  • 8 Coradini PP. et al. Ototoxicity from cisplatin therapy in childhood cancer. J Pediatr Hematol Oncol 2007; 29: 355-60.
  • 9 Dein RA. et al. The reproductive potential of young men and women with Hodgkin’s disease. Obstet Gynecol Surv 1984; 39 (08) 474-82.
  • 10 Dieluweit U. et al. Social outcomes of long-term survivors of adolescent cancer. Psycho-Oncology. 2010 Feb 5; DOI: 10.1002/pon.1692.
  • 11 Heim ME, Krauss O, Schwarz R. Effect of cancer in rehabilitation of fatigue and quality of life parameters. Psycho-Oncology 2001; 10: 26.
  • 12 Hobbie WL. et al. Symptoms of posttraumatic stress in young adult survivors of childhood cancer. J Clin Oncol 2000; 18: 4060-6.
  • 13 Horner MJ. et al. SEER Cancer Statistics Review, 1975–2006. National Cancer Institute. Bethesda, MD: http://seer.cancer.gov/csr/1975_2006/ based on November 2008 SEER data submission, posted to the SEER web site, 2009.
  • 14 Kaatsch P. et al. Second malignant neoplasms after childhood cancer in Germany – Results from the long-term follow-up of the German Childhood Cancer Registry. Strahlenther Onkol 2009; 185 (Suppl. 02) 8-10.
  • 15 Kazak AE. et al. Posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) in families of adolescent childhood cancer survivors. J Pediatr Psychol 2004; 29: 211-9.
  • 16 Koocher GP, O’Malley JE. The Damocles syndrome: psychosocial consequences of surviving childhood cancer. New York: McGraw-Hill; 1981
  • 17 Langeveld NE. et al. Quality of life, self-esteem and worries in young adult survivors of childhood cancer. Psycho-Oncology 2004; 13: 867-81.
  • 18 Meadows AT. Second tumours. Eur J Cancer 2001; 37: 2074-9.
  • 19 Meadows AT. et al. Second neoplasms in survivors of childhood cancer: Findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol 2009; 27: 2356-62.
  • 20 Mesa RA. et al. The burden of fatigue and quality of life in myeloproliferative disorders (MPDs): an international Internet-based survey of 1179 MPD patients. Cancer 2007; 109: 68-76.
  • 21 Mulhern RK, Palmer SL. Neurocognitive late effects in pediatric cancer. Current Problems in Cancer 2003; 27: 177-97.
  • 22 Ris MD, Noll RB. Long-term neurobehavioral outcome in pediatric brain-tumor patients: Review and methodological critique. J Clinical and Experimental Neuropsychology 1994; 16: 21-42.
  • 23 Rosenberg SA, Kaplan HS. The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin’s disease: 1962–1984. Int J Radiat Oncol Biol Phys 1985; 11: 5-22.
  • 24 Rourke MT. et al. Posttraumatic stress disorder (PTSD) in young adult survivors of childhood cancer. Pediatric Blood and Cancer 2007; 49: 177-82.
  • 25 Rueffer U. et al. Male gonadal dysfunction in patients with Hodgkin’s disease prior to treatment. Ann Oncol 2001; 12: 1307-11.
  • 26 Ruffer JU. et al. Fatigue in long-term survivors of Hodgkin’s lymphoma; a report from the German Hodgkin Lymphoma Study Group (GHSG). Eur J Cancer 2003; 39: 2179-86.
  • 27 Schröder HM. et al. S3-Leitlinie: Psychosoziale Versorgung in der Pädiatrischen Onkologie und Hämatologie [Psychosocial care in pediatric oncology and Haematology]. Gesellschaft für Pädiatrische Onkologie und Hämatologie (Hrsg). 2008 www uniduesseldorf.de/AWMF/ll/025–002m.htm
  • 28 Schwartz L, Drotar D. Posttraumatic stress and related impairment in survivors of childhood cancer in early adulthood compared to healthy peers. J Pediatr Psychol 2006; 31: 356-66.
  • 29 Seitz DCM. et al. Posttraumatic stress, depression, and anxiety among adult long term survivors of cancer in adolescence. European Journal of Cancer 2010; 46: 1596-606.
  • 30 Seitz DCM. et al. Life satisfaction in adult survivors of cancer during adolescence: What contributes to the latter satisfaction with life?. Quality of Life Research. 2010 DOI: 10.1007/s11136–010–9739–9.
  • 31 Shahrokni A. et al. Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene. JOP 2009; 10: 215-20.
  • 32 Smets EM. et al. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res 1995; 39: 315-25.
  • 33 Sønderkaer S. et al. Long-term neurological outcome of childhood brain tumors treated by surgery only. J Clin Oncol 2003; 21: 1347-51.
  • 34 Spinetta JJ. et al. Optimal care for the child with cancer: A summary statement from the SIOP Working Committee on Psychosocial Issues in Pediatric Oncology. Pediatric Blood and Cancer 2009; 52: 904-7.
  • 35 Turner CD. et al. Late effects of therapy for pediatric brain tumor survivors. Journal of Child Neurology 2009; 24: 1455-63.
  • 36 van Spronsen DJ. et al. Prevalence of co-morbidity and its relationship to treatment among unselected patients with Hodgkin’s disease and non-Hodgkin’s lymphoma, 1993–1996. Ann Hematol 1999; 78: 315-9.
  • 37 Viviani S. et al. Gonadal toxicity after combination chemotherapy for Hodgkin’s disease. Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol 1985; 21: 601-5.
  • 38 von Essen L. et al. Self-esteem, depression and anxiety among Swedish children and adolescents on and off cancer treatment. Acta Paediatrica, International Journal of Paediatrics 2000; 89: 229-36.
  • 39 Winqvist S. et al. Cognitive functions of young adults who survived childhood cancer. Applied Neuropsychology 2001; 08: 224-33.