Thromb Haemost 1995; 74(01): 218-223
DOI: 10.1055/s-0038-1642680
Colloquium
Platelets,Leukocytes and Endothelial Cells During Inflammation and Thrombosis
Schattauer GmbH Stuttgart

Platelet Activation by Polymorphonuclear Leukocytes: Role of Cathepsin G and P-Selectin

Chiara Cerletti
“Giulio Bizzozero ” Laboratory of Platelet and Leukocyte Pharmacology, Istituto di Ricerche Farmacologiche “Mario Negri ”, Consorzio “Mario Negri Sud ”, Santa Maria Imbaro, Italy
,
Virgilio Evangelista
“Giulio Bizzozero ” Laboratory of Platelet and Leukocyte Pharmacology, Istituto di Ricerche Farmacologiche “Mario Negri ”, Consorzio “Mario Negri Sud ”, Santa Maria Imbaro, Italy
,
Marina Molino
On leave of absence at: Departments of Medicine and Pathology University of Pennsylvania, Philadelphia, PA, USA
,
Giovanni de Gaetano
“Giulio Bizzozero ” Laboratory of Platelet and Leukocyte Pharmacology, Istituto di Ricerche Farmacologiche “Mario Negri ”, Consorzio “Mario Negri Sud ”, Santa Maria Imbaro, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

 
  • References

  • 1 Connell RS, Swank RL, Webb MC. The development of pulmonary ultrastractural lesions during hemorrhagic shock. J Trauma 1975; 15: 116-129
  • 2 Stimler NP, Hugli TE, Bloor CM. Pulmonary injury induced by C3a and C5a anaphilotoxins. Am J Pathol 1980; 100: 327-348
  • 3 Tvedten HV, Till GO, Ward PA. Mediators of lung injury in mice following systemic activation of complement. Lab Invest 1985; 119: 92-100
  • 4 Issekutz AC, Ripley M, Jackson JR. Role of neutrophils in the deposition of platelets during acute inflammation. Lab Invest 1983; 49: 716-724
  • 5 Johnson RJ, Alpers CE, Pritzl P, Schulze M, Baker P, Prachno C, Couser WG. Platelets mediate neutrophil-dependent immune complex nephritis in the rat. J Clin Invest 1988; 82: 1225-1235
  • 6 Bednar M, Smith B, Pinto A, Mullane KM. Neutrophil depletion suppresses In-labeled platelet accumulation in infarcted myocardium. J Cardiovasc Pharmacol 1985; 7: 906-912
  • 7 Palabrica T, Lobb R, Furie BC, Aronovitz M, Benjamin C, Hsu Y-M, Sajer SA, Furie B. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature 1992; 359: 848-851
  • 8 Lehr H-A, Olofsson AM, Carew TE, Vajkoczy P, von Andrian UH, Hiibner C, Bemdt MC, Steinberg D, Messmer K, Arfors KE. P-selectin mediates the interaction of circulating leukocytes with platelets and microvascular endothelium in response to oxidized lipoprotein in vivo. Lab Invest 1994; 71: 380-386
  • 9 Repine JE. Scientific perspectives on adult respiratory distress syndrome. Lancet 1992; 339: 466-469
  • 10 Henson PM. Interactions between neutrophils and platelets. Lab Invest 1990; 62: 391-393
  • 11 Cerletti C, Evangelista V, de Gaetano G. Polymorphonuclear leucocyte- dependent modulation of platelet function: relevance to the pathogenesis of thrombosis. Pharmacol Res 1992; 26: 261-268
  • 12 Bazzoni G, Dejana E, Del Maschio A. Platelet-dependent modulation of neutrophil function. Pharmacol Res 1992; 26: 269-272
  • 13 Faint RW. Platelet-neutrophil interactions: their significance. Blood Reviews 1992; 6: 83-91
  • 14 Ernst E, Hammerschmidt DE, Bagge U, Matrai A, Dormandy JA. Leukocytes and the risk of ischemic diseases. JAMA 1987; 257: 2318-2324
  • 15 Clark RA, Klebanoff SJ. Neutrophil-platelet interaction mediated by myeloperoxidase and hydrogen peroxide. J Immunol 1980; 124: 399-405
  • 16 Handin RI, Karabin R, Boxer GJ. Enhancement of platelet function by superoxide anion. J Clin Invest 1977; 59: 959-965
  • 17 Pratico D, Iuliano L, Alessandri C, Camastra C, Violi F. Polymorphonuclear leukocyte-derived 02-reactive species activate primed platelets in human whole blood. Am J Physiol 1993; 264 H 1582-1587
  • 18 Coeffier E, Joseph D, Prevost MC, Vargaftig BB. Platelet-leukocyte interaction: activation of rabbit platelets by FMLP-stimulated neutrophils. Br J Pharmacol 1987; 92: 393-406
  • 19 Chignard M, Selak MA, Smith JB. Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin). Proc Natl Acad Sci USA 1986; 83: 8609-8613
  • 20 Hallgren R, Venge P. Cationic proteins of human granulocytes. Effects on human platelet aggregation and serotonin release. Inflammation 1976; 1: 359-370
  • 21 Bykowska K, Kaczanowska J, Karpowicz M, Stachurska J, Kopec M. Effect of neutral proteases from blood leukocytes on human platelets. Thromb Haemostas 1983; 50: 768-772
  • 22 Del Maschio A, Evangelista V, Rajtar G, Chen ZM, Cerletti C, de Gaetano G. Platelet activation by polymorphonuclear leukocytes exposed to chemotactic agents. Am J Physiol 1990; 258: H870-H879
  • 23 Evangelista V, Rajtar G, de Gaetano G, White JG, Cerletti C. Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: the activity of cathepsin G is not prevented by antiproteinases. Blood 1991; 77: 2379-2388
  • 24 Selak MA. Neutrophil elastase potentiates cathepsin G-induced platelet activation. Thromb Haemostas 1992; 68: 570-576
  • 25 Renesto P, Chignard M. Enhancement of cathepsin G-induced platelet activation by leukocyte elastase: consequence for the neutrophil-mediated platelet activation. Blood 1993; 82: 139-144
  • 26 Maugeri N, Evangelista V, Celardo A, Dell’Elba G, Martelli N, Piccardoni P, de Gaetano G, Cerletti C. Polymorphonuclear leukocyte-platelet interaction: role of P-selectin in thromboxane B2and leukotriene C4cooperative synthesis. Thromb Haemostas 1994; 72: 450-456
  • 27 Selak MA, Chignard M, Smith JB. Cathepsin Gisa strong platelet agonist released by neutrophils. Biochem J 1988; 251: 293-299
  • 28 Molino M, Di Lallo M, de Gaetano G, Cerletti C. Intracellular Ca2+ rise in human platelets induced by polymorphonuclear-leucocyte-derived cathepsin. G. Biochem J 1992; 288: 741-745
  • 29 Molino M, Di Lallo M, de Gaetano G, Cerletti C. Platelet protein kinase C (PKC) activation by neutrophil-derived cathepsin. G. Thromb Haemostas 1993; 69: 1163 (Abstract)
  • 30 Selak MA, Cathepsin G. activates platelets in the presence of plasma and stimulates phosphatidic acid formation and lysosomal enzyme release. Platelets 1993; 4: 85-89
  • 31 Rotondo S, Evangelista V, Cerletti C. Platelet activation by cathepsin G: mechanisms regulating arachidonic acid release and serotonin secretion. Thromb Haemostas. 1995 in press: (Abstract)
  • 32 Komecki E, Ehrlich YH, Egbring R, Gramse M, Seitz R, Eckardt A, Lukasiewicz H, Niewiarowski S. Granulocyte-platelet interactions and platelet fibrinogen receptor exposure. Am J Physiol 1988; 255 H 651-658
  • 33 Molino M, Di Lallo M, Martelli N, de Gaetano G, Cerletti C. Effects of leukocyte-derived cathepsin G on platelet membrane glycoprotein Ib-IX and Ilb-IIIacomplexes: a comparison with thrombin. Blood 1993; 82: 2442-2451
  • 34 LaRosa CA, Rohrer MJ, Benoit SE, Barnard MR, Michelson AD. Neutrophil cathepsin G modulates the platelet surface expression of the glycoprotein (GP) Ib-IX complex by proteolysis of the von Willebrand factor binding site on GPIba and by a cytoskeletal-mediated redistribution of the remainder of the complex. Blood 1994; 84: 158-168
  • 35 Pidard D, Renesto P, Bemdt MC, Rabhi S, Clemetson KJ, Chignard M. Neutrophil proteinase cathepsin G is proteolytically active on the human platelet glycoprotein Ib-IX receptor: characterization of the cleavage sites within the glycoprotein lb a subunit. Biochem J 1994; 303: 489-498
  • 36 Selak MA, Smith JB. Cathepsin G binding to human platelets. Evidence for a specific receptor Biochem J 1990; 266: 55-62
  • 37 Selak MA. Cathepsin G and thrombin: evidence for two different platelet receptors. Biochem J 1994; 297: 269-275
  • 38 Molino M, Blanchard N, Belmonte E, Tarver AP, Abrams C, Hoxie JA, Cerletti C, Brass LF. Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin. G. J Biol Chem. 1995 in press
  • 39 Nystedt S, Emilsson K, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci USA 1994; 91: 9208-9212
  • 40 Coughlin SR. Protease-activated receptors start a family. Proc Natl Acad Sci USA 1994; 91: 9200-9202
  • 41 Johnson KJ, Varani J. Substrate hydrolysis by immune complex-activated neutrophils: effect of physical presentation of complexes and protease inhibitors. J Immunol 1981; 127: 1875-1879
  • 42 Weiss SJ, Cumutte JT, Regiani S. Neutrophil-mediated solubilization of the subendothelial matrix: oxidative and non oxidative mechanisms of proteolysis used by normal and chronic granulomatous disease phagocytes. J Immunol 1986; 136: 636-641
  • 43 Weitz JI, Huang AJ, Landman SL, Nicholson SC, Silverstein SC. Elastase- mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases. J Exp Med 1987; 166: 1836-1850
  • 44 Campbell EJ, Campbell MA. Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization. J Cell Biol 1988; 106: 667-676
  • 45 Westlin WF, Gimbrone MA. Neutrophil-mediated damage to human vascular endothelium. Am J Pathol 1993; 142: 117-128
  • 46 Jungi TW, Spycher MO, Nydegger UE, Barandun S. Platelet-leukocyte interaction: selective binding of thrombin-stimulated platelets to human monocytes, polymorphonuclear leukocytes, and related cell lines. Blood 1986; 67: 629-636
  • 47 Larsen E, Celi A, Gilbert GE, Furie BC, Erban JK, Bonfanti R, Wagner DD, Furie B. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 1989; 59: 305-312
  • 48 Hamburger SA, McEver RP. GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood 1990; 75: 550-554
  • 49 Evangelista V, Piccardoni P, White JG, de Gaetano G, Cerletti C. Cathepsin G-dependent platelet stimulation by activated polymorphonuclear leukocytes and its inhibition by antiproteinases: role of P-selectin-mediated cell-cell adhesion. Blood 1993; 81: 2947-2957
  • 50 Spangenberg P, Redlich H, Bergmann I, Losche W, Gotzrath M, Kehrel B. The platelet glycoprotein Ilb/IIIa complex is involved in the adhesion of activated platelets of leukocytes. Thromb Haemostas 1993; 70: 514-521
  • 51 Diacovo TG, deFougerolles AR, Bainton DF, Springer TA. A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2. J Clin Invest 1994; 94: 1243-1251
  • 52 Evangelista V, Manarini S, Martelli N, de Gaetano G, McGregor JL, Cerletti C. fMLP increases platelet adhesion to granulocytes: role of CD18. Thromb Haemostas. 1995 in press: (Abstract)
  • 53 Harlan JM. Neutrophil-mediated vascular injury. Acta Med Sc 1987; 715 (suppl.) 123-129
  • 54 Nagata K, Tsuji T, Todoroki N, Katagiri Y, Tanoue K, Yamazaki H, Hanai N, Irimura T. Activated platelets induce superoxide anion release by monocytes and neutrophils through P-selectin (CD62). J Immunol 1993; 151: 3267-3273
  • 55 Celi A, Pellegrini G, Lorenzet R, De Blasi A, Ready N, Furie BC, Furie B. P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci USA 1994; 91: 8767-8771
  • 56 Marcus AJ. Thrombosis and inflammation as multicellular processes: pathophysiologic significance of transcellular metabolism. Blood 1990; 76: 1903-1907
  • 57 Marcus AJ, Broekman MJ, Safier LB, Ullman HL, Islam N. Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro. Biochem Biophys Res Commun 1982; 109: 130-137
  • 58 Fiore S, Serhan CN. Formation oflipoxins and leukotrienes during receptor- mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils. J Exp Med 1990; 172: 1451-1457
  • 59 Palmantier R, Borgeat P. Thrombin-activated platelets promote leukotriene B4 synthesis in polymorphonuclear leucocytes stimulated by physiological agonists. Br J Pharmacol 1991; 103: 1909-1916
  • 60 Maclouf JA, Murphy RC. Transcellular metabolism of neutrophil-derived leukotriene A4by human platelets. A potential cellular source ofleukotriene C4 J Biol Chem 1988; 263: 174-181
  • 61 Serhan CN, Sheppard K-A. Lipoxin formation during human neutrophil- platelet interactions. Evidence for the trasformation of leukotriene A4 by platelet 12-lipoxygenase in vitro J Clin Invest 1990; 85: 772-780
  • 62 Maugeri N, Evangelista V, Piccardoni P, Dell’Elba G, Celardo A, de Gaetano G, Cerletti C. Transcellular metabolism of arachidonic acid: increased platelet thromboxane generation in the presence of activated polymorphonuclear leukocytes. Blood 1992; 80: 447-451
  • 63 McCulloch RK, Croft KD, Vandongen R. Enhancement of platelet 12- HETE production in the presence of polymorphonuclear leukocytes during calcium ionophore stimulation. Biochim Biophys Acta 1992; 1133: 142-146
  • 64 Palmantier R, Borgeat P. Transcellular metabolism of arachidonic acid in platelets and polymorphonuclear leukocytes activated by physiological agonists: enhancement of leukotriene B4 synthesis. In: Cell-cell interactions in the release of inflammatory mediators. Wong PY-K, Seihan CN. eds. Plenum Press; New York: 1991: 73-89
  • 65 Brady HR, Seihan CN. Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: inhibition by antibodies against CD 18 and L-selectin. Biochem Biophys Res Commun 1992; 186: 1307-1314
  • 66 Renesto P, Ferrer-Lopez P, Chignard M. Interference of recombinant eglin C, a proteinase inhibitor extracted from leeches, with neutrophil -mediated platelet activation. Lab Invest 1990; 62: 409-416
  • 67 Evangelista V, Piccardoni P, Maugeri N, de Gaetano G, Cerletti C. Inhibition by heparin of platelet activation induced by neutrophil-derived cathepsin G. Eur J Pharmacol 1992; 216: 401-405
  • 68 Renesto P, Balloy V, Kamimura T, Masuda K-i, Imaizumi A, Chignard M. Inhibition by recombinant SLPI and half-SLPI (Asn55-Ala107) of elastase and cathepsin G activities: consequence for neutrophil-platelet cooperation. Br J Pharmacol 1993; 108: 1100-1106
  • 69 Skinner MP, Lucas CM, Bums GF, Chesterman CN, Bemdt MC. GMP-140 binding to neutrophils is inhibited by sulfated glycans. J Biol Chem 1991; 266: 5371-5374
  • 70 Ferrer-Lopez P, Renesto P, Prevost MC, Gounon P, Chignard M. Heparins inhibit neutrophil-induced platelet activation via cathepsin G. J Lab Clin Med 1992; 119: 231-239
  • 71 Bazzoni G, Beltran Nunez A, Mascellani G, Bianchini P, Dejana E, Del Maschio A. Effect of heparin, dermatan sulfate, and related oligo-derivates on human polymorphonuclear leukocyte functions. J Lab Clin Med 1993; 121: 268-275
  • 72 Rajtar G, Marchi E, de Gaetano G, Cerletti C. Effects of glycosaminoglycans on platelet and leucocyte function: role of N-sulfation. Biochem Pharmacol 1993; 46: 958-960
  • 73 Evangelista V, Piccardoni P, de Gaetano G, Cerletti C. Defibrotide inhibits platelet activation by cathepsin G released from stimulated polymorphonuclear leukocytes. Thromb Haemostas 1992; 67: 660-664
  • 74 Colli S, Tremoli E. Multiple effects of dipyridamole on neutrophils and mononuclear leukocytes: adenosine-dependent and adenosine-independent mechanisms. J Lab Clin Med 1991; 118: 136-145
  • 75 European Working Group on Critical Leg Ischaemia. Second european consensus document on chronic critical leg ischemia. Circulation. 1991 84. (suppl.) IV-l-IV-26
  • 76 Dinerman JL, Mehta JL. Endothelial, platelet and leukocyte interactions in ischemic heart disease: insights into potential mechanisms and their clinical relevance. J Am Coll Cardiol 1990; 16: 207-222
  • 77 Mehta J, Dinerman J, Mehta P, Salden TG P, Lawson D, Donnelly WH, Wallin R. Neutrophil function in ischemic heart disease. Circulation 1989; 79: 549-556
  • 78 Carry M, Korley V, Willerson JT, Weigelt L, Ford-Hutchinson AW, Tagari P. Increased urinary leukotriene excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation Circulation 1992; 85: 230-236
  • 79 Neri Semeri GG, Abbate R, Gori AM, Attanasio M, Martini F, Giusti B, Dabizzi P, Poggesi L, Modesti P A, Trotta F, Rostagno C, Boddi M, Gensini GF. Transient intermittent lymphocyte activation is responsible for the instability of angina. Circulation 1992; 86: 790-797
  • 80 Mazzone A, De Servi S, Ricevuti G, Mazzucchelli I, Fossati G, Pasotti D, Bramucci E, Angoli L, Marsico F, Specchia G, Notario A. Increased expression of neutrophil and monocyte adhesion molecules in unstable coronary artery disease. Circulation 1993; 88: 358-363
  • 81 Brezinski DA, Nesto RW, Seihan CN. Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy Circulation 1992; 86: 56-63
  • 82 Bizzozero J. Uber einen neuen foimbestandteil des blutes und dessen rolle bei der thrombose und blutgerinnung. Virchows Arch Pathol Anat Physiol Klin Med 1882; 90: 261-332