Download PDF
Thromb Haemost 1995; 74(01): 406-410
DOI: 10.1055/s-0038-1642712
Symposium
Vaascular Growth Factor
Schattauer GmbH Stuttgart

Inhibition of Intravascular Thrombosis and Vascular Smooth Muscle Cell Proliferation by Gene Therapy

Moshe Y Flugelman
Department of Cardiology, Lady Davis Carmel Medical Center and the Faculty of Medicine, Technion IIT, Haifa, Israel
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

  PDF Download  Permissions and Reprints
 

  • References

  • 1 Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801-809
    CrossrefPubMedGoogle Scholar
  • 2 Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndrome. N Eng I Med 1992; 326: 242-250-310-318
    PubMedGoogle Scholar
  • 3 Flugelman MY, Virmani R, Correa R, Yu Z-X, Farb A, Leon BM, Fu YM, Casscells W, Epstein SE. Smooth muscle cell abundance and fibroblast growth factors in coronary lesions of patients with non fatal unstable angina: a clue to the mechanism of transformation from the stable to the unstable clinical state. Circulation 1993; 88: 2493-2500
    CrossrefPubMedGoogle Scholar
  • 4 Strauss BH, Chisholm RJ, Keeley FW, Gotlieb AI, Logan RA, Armstrong PW. Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. Circ Res 1994; 75: 650-658
    CrossrefPubMedGoogle Scholar
  • 5 Casscells W. Endothelial and smooth muscle cell migration: critical factors in restenosis. Circulation 1992; 86: 723-729
    CrossrefPubMedGoogle Scholar
  • 6 Ferns GA A, Raines EW, Sprugel KH, Motani AS, Reidy MA, Ross R. Inhibition of neointimal smooth muscle cells accumulation after angioplasty by an antibody to PDGF. Science 1991; 253: 1129-1132
    CrossrefPubMedGoogle Scholar
  • 7 Wilcox JH. Thrombin and other potential mechanisms underlying restenosis. Circulation 1991; 84: 432-435
    CrossrefPubMedGoogle Scholar
  • 8 Bar Shavit R, Benezra M, Sabbah V, Bode W, Vlodavsky I. Thrombin as a multifunctional protein: induction of cell adhesion and proliferation. Am J Res Cell and Moll Biol 1992; 6: 123-130
    PubMedGoogle Scholar
  • 9 Benezra M, Vlodavsky I, Ishai-Michaeli R, Neufeld G, Bar-Shavit R. Thrombin-induced release of active basic fibroblast growth factor-heparan sulfate complexes from subendothelial extra-cellular matrix. Blood 1993; 82: 3324-3332
    PubMedGoogle Scholar
  • 10 Thyberg J, Hedin U, Sjolund M, Palmberg L, Bottger BA. Regulation of differentiated properties and proliferation of arterial smooth muscle cells. Arteriosclerosis 1990; 10: 966-990
    CrossrefPubMedGoogle Scholar
  • 11 Anderson WF. Human gene therapy. Science 1992; 256: 808-813
    CrossrefPubMedGoogle Scholar
  • 12 Mulligan RC. The basic science of gene therapy. Science 1993; 260: 926-932
    CrossrefPubMedGoogle Scholar
  • 13 Swain JL. Gene therapy; a new approach to the treatment of cardiovascular disease. Circulation 1989; 80: 1495-1496
    CrossrefPubMedGoogle Scholar
  • 14 Riessen R, Isner JM. Prospects for site-specific delivery of pharmacologic and molecular therapies. J Am J Cardiol 1994; 23: 1234-1244
    PubMedGoogle Scholar
  • 15 Nabel EG, Plautz G, Boyce FM, Stanley JC, Nabel GJ. Recombinant gene expression in vivo within endothelial cells of the arterial wall. Science 1989; 244: 1342-1344
    CrossrefPubMedGoogle Scholar
  • 16 Flugelman MY, Leon MB, Bowman RL, Virmani R, Anderson WF, Dichek DA. Retention of seeded cells on balloon expanded stents under flow conditions. Circulation 1990; (Suppl. 82) Suppl. 3: 72
    PubMedGoogle Scholar
  • 17 Flugelman MY, Virmani R, Leon MB, Bowman RL, Dichek DA. Genetically engineered endothelial cells remain adherent and viable after stent deployment and exposure to flow in vitro. Circ 1992; 70: 348-354
    PubMedGoogle Scholar
  • 18 Flugelman MY, Rome JJ, Virmani R, Newman KD, Dichek DA. Detection of genetically engineered endothelial cells seeded on endovascular prosthesis ten days after in vivo deployment. J Mol Cell Cardiol 1993; 25 Suppl (Suppl. 01) 38S
    PubMedGoogle Scholar
  • 19 Flugelman MY, Jaklitsch MT, Newman KD, Casscells SW, Bratt-hauer GL, Dichek DA. Low levels in vivo gene transfer into the arterial wall through a perforated balloon catheter. Circulation 1992; 85: 1110-1117
    CrossrefPubMedGoogle Scholar
  • 20 Schneider M, French BA. The advent of adenovirus-gene therapy for cardiovascular disease. Circulation 1993; 88: 1937-1942
    CrossrefPubMedGoogle Scholar
  • 21 Rome JJ, Shayani V, Flugelman MY, Newman KD, Farb A, Virmani R, Dichek DA. Anatomic barriers determine the distribution of in vivo gene transfer into the arterial wall: modeling with microscopic tracer particles and verification with a recombinant adenoviral vector. Atherosclerosis and Thrombosis 1994; 14: 148-161
    PubMedGoogle Scholar
  • 22 Serruys PW, de Jaegere P, Kiemeneij F. et al A comparison of balloon expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. N Engl J Med 1994; 331: 489-495
    CrossrefPubMedGoogle Scholar
  • 23 Fischman DL, Leon MB, Bairn DS. et al. A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med 1994; 331: 496-501
    CrossrefPubMedGoogle Scholar
  • 24 Correa R, Yu Z-X, Flugelman MY, Roberts WC, Kent K, Ferrans VJ, Casscells W. Evidence of fibroblast growth factor expression in smooth muscle cells and macrophages of atherosclerotic and restenotic human arteries. Circulation 1991; 84 Suppl (Suppl. 02) S460
    PubMedGoogle Scholar
  • 25 Epstein SE, Speir E, Unger EF, Guzman RJ, Finkel T. The basis molecular strategies for treating coronary restenosis after angioplasty. J Am Coll Cardiol 1994; 23: 1278-1288
    CrossrefPubMedGoogle Scholar
  • 26 Dichek DA, Nussbaum O, Degen SJ F, Anderson WF. Enhancement of fibrinolytic activity of sheep endothelial cells by retroviral vector-mediated gene transfer. Blood 1991; 77: 533-541
    PubMedGoogle Scholar
  • 27 Lindner V, Riedy MA. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc Natl Acad Sci USA 1991; 88: 3739-3743
    CrossrefPubMedGoogle Scholar
  • 28 Kasahara N, Dozy AM, Kan YW. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science 1994; 266: 1373-1376
    CrossrefPubMedGoogle Scholar
  • 29 Lee SW, Trapnell BC, Rade JJ, Virmani R, Dichek DA. In vivo adenoviral vector-mediated gene transfer into balloon-injured rat carotid arteries. Circulation Research 1993; 73: 797-807
    CrossrefPubMedGoogle Scholar
  • 30 Schulick AH, Newman KD, Dichek DA. A therapeutic window for in vivo adenoviral vector mediated gene transfer. Circulation 1994; 90 Suppl (Suppl. 04) I516
    PubMedGoogle Scholar
  • 31 Feldman LJ, Steg PG, Zheng LP, Kearney M, Barry JJ, Perri-caudet M, Isner JM. Percutaneous adeno-mediated gene delivery to normal and atherosclerotic arteries in vivo: a comparative study. Circulation 1994; 90 Suppl (Suppl. 04) I 517
    PubMedGoogle Scholar
  • 32 Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843-845
    CrossrefPubMedGoogle Scholar
  • 33 Ohno T, Gordon D, San H, Pompili VJ, Imperiale MJ, Nabel GJ, Nabel EG. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science 1994; 265: 781-784
    CrossrefPubMedGoogle Scholar
  • 34 Morishita R, Gibbons GH, Ellison KE, Masatoshi Nakajima, von der Leyen H, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest 1994; 93: 1458-1464
    CrossrefPubMedGoogle Scholar
  • 35 Coghlan A. Gene superclub signs up top players. New Scientist 1994; 1952: 4
    PubMedGoogle Scholar