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Thromb Haemost 1990; 63(02): 183-186
DOI: 10.1055/s-0038-1645192
Original Article
Schattauer GmbH Stuttgart

Dilute aPTT Prolongation by Antiphospholipid Antibodies in Patients with Liver Cirrhosis

Francesco Violi
The Istituto di I Clinica Medica, University of Rome “La Sapienza”, Italy
,
Domenico Ferro
The Istituto di I Clinica Medica, University of Rome “La Sapienza”, Italy
,
Claudio Quintarelli
The Istituto di I Clinica Medica, University of Rome “La Sapienza”, Italy
,
Cesare Alessandri
The Istituto di I Clinica Medica, University of Rome “La Sapienza”, Italy
,
Mirella Saliola
The Istituto di I Clinica Medica, University of Rome “La Sapienza”, Italy
,
Guido Valesini
The Istituto di I Clinica Medica, University of Rome “La Sapienza”, Italy
,
Francesco Balsano
The Istituto di I Clinica Medica, University of Rome “La Sapienza”, Italy
› Author Affiliations
Further Information

Publication History

Received 11 April 1989

Accepted after revision 15 November 1989

Publication Date:
02 July 2018 (online)

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Summary

The behaviour of aPTT, as assessed by standard or diluted phospholipid mixture, was investigated in 20 patients suffering from liver cirrhosis. Standard aPTT was prolonged in 13 but it was corrected by 1:1 mixture with normal plasma. Dilute aPTT performed in samples mixed 1:1 with normal plasma and calculated by the difference in time between 1:80 and 1:5 phospholipid mixture was prolonged in 9 patients, who had also significantly higher titre of anticardiolipin antibodies (p <0.005). Unlike patients’ plasma with normal dilute aPTT, the addition of 0.05 M PC/PS liposomes to patient’s plasma with prolonged dilute aPTT significantly shortened dilute aPTT (p <0.001).

This study shows the presence of antiphospholipid antibodies in some patients with liver cirrhosis; this seems to be responsible for the prolongation of dilute aPTT.

 

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