Download PDF
Thromb Haemost 1990; 63(01): 087-090
DOI: 10.1055/s-0038-1645692
Original Article
Schattauer GmbH Stuttgart

Effect of Angiotensin II on Collagen-Induced Platelet Activation in Normotensive Subjects

Stephen L Swartz
The Department of Endocrinology/Hypertension, Brigham and Women’s Hospital, Boston, MA, USA
,
Thomas J Moore
The Department of Endocrinology/Hypertension, Brigham and Women’s Hospital, Boston, MA, USA
› Author Affiliations
Further Information

Publication History

Received 30 May 1989

Accepted after revision 02 October 1989

Publication Date:
02 July 2018 (online)

  PDF Download  Permissions and Reprints

Summary

We examined the effect of angiotensin II (AII) on platelet activation in 15 normotensive volunteers. By measuring the initial phase of platelet aggregation on the optical density aggregation tracing and generation of thromboxane production, we demonstrated that AII enhances collagen-induced platelet activation. This enhancement in platelet activation is significantly greater when subjects are on a high salt than on a low salt diet. Furthermore, the increase in platelet activation parallels an increase in platelet AII receptor number. These parallel changes in platelet activation and platelet AII receptors provide a possible mechanism through which AII may affect platelet function.

Keywords

Platelet aggregation - Angiotensin II - Platelet angiotensin receptor
 

  • References

  • 1 Moore TJ, Williams GH. Angiotensin II receptors on human platelets. Circ Res 1982; 51: 314-320
    CrossrefPubMedGoogle Scholar
  • 2 Moore TJ, Taylor T, Williams GH. Human platelet angiotensin II receptors: Regulation by the circulating angiotensin level. J Clin Endocrinol Metab 1984; 58: 778-782
    CrossrefPubMedGoogle Scholar
  • 3 Gunther S, Gimbrone MA, Alexander Jr RW. Identification and characterization of the high affinity vascular angiotensin II receptor in rat mesenteric artery. Circ Res 1981; 47: 278-286
    PubMedGoogle Scholar
  • 4 Poplawski A. The effect of angiotensin II on the platelet aggregation induced by adenosine-diphosphate, epinephrine and thrombin. Experientia 1970; 26: 86-87
    CrossrefPubMedGoogle Scholar
  • 5 Ding YA, MacIntyre DE, Kenyon CJ, Semple PF. Potentiation of adrenaline-induced platelet aggregation by angiotensin II. Thromb Haemostas 1985; 54: 717-720
    PubMedGoogle Scholar
  • 6 Swartz SL, Williams GH, Hollenberg NK, Levine L, Dluhy RG, Moore TJ. Captopril-induced changes in prostaglandin production. Relationship to vascular responses in normal man. J Clin Invest 1980; 65: 1257-1264
    CrossrefPubMedGoogle Scholar
  • 6a Gambhir KK, Archer JA, Bradley CJ. Characteristics of human erythrocyte insulin receptors. Diabetes 1978; 27: 701-718
    CrossrefPubMedGoogle Scholar
  • 7 Snedecor GW, Cochran WG. Statistical Methods. Iowa State University Press; Ames, IA: 1967
    Google Scholar
  • 8 Ipsen J, Feigl P. Bancroft’s Introduction to Biostatistics. Harper and Row New York: 1979
    Google Scholar
  • 9 Douglas JG, Catt KJ. Regulation of angiotensin II receptors in rat adrenal cortex by dietary electrolytes. J Clin Invest 1976; 58: 834-843
    CrossrefPubMedGoogle Scholar
  • 10 Someya N, Morotomi Y, Kodama K, Kida O, Higa T, Kondo T, Tanaka K. Suppressive effect of captopril on platelet aggregation in essential hypertension. J Cardiovasc Pharmacole 1984; 6: 840-843
    PubMedGoogle Scholar
  • 11 Haller H, Ludersdorf M, Lenz T, Distler A, Philipp T. Changes in sensitivity to angiotensin II in platelets. J Cardiovasc Pharmacol 1987; (Suppl. 10) 44-46
    PubMedGoogle Scholar