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Thromb Haemost 1989; 61(03): 419-422
DOI: 10.1055/s-0038-1646607
Original Article
Schattauer GmbH Stuttgart

Expression of Fibrinogen Receptors in Platelets of Migraine Patients - Correlation with Platelet GPIIb Content and Plasma Cholesterol

Bogdan Walkowiak
The Department of Biophysics, Medical School in Lódź, Lódź, Poland
,
Wojciech Kozubski
*   The Department of Neurology, Medical School in Lódź, Lódź, Poland
,
Zofia Pawlowska
The Department of Biophysics, Medical School in Lódź, Lódź, Poland
,
Antoni Prusinski
*   The Department of Neurology, Medical School in Lódź, Lódź, Poland
,
Czeslaw S Cierniewski
The Department of Biophysics, Medical School in Lódź, Lódź, Poland
› Author Affiliations
Further Information

Publication History

Received 29 June 1988

Accepted after revision 10 March 1989

Publication Date:
24 July 2018 (online)

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Summary

Binding of fibrinogen to platelets washed from blood of migraine patients (n = 30) and control donors (n = 24) was compared. In addition, contents of platelet glycoprotein IIb and platelet fibrinogen were determined in both groups by radioimmunoassay. The receptor capacity for fibrinogen in platelets activated by ADP was significantly higher (p <0.01) in migraine patients (52,505 α 4,925) than in controls (33,881 λ 3,965). The mean contents of GPIIb (3.51 α 0.34 μg/108 platelets) and fibrinogen (37 .26 α 4.05 μg/108 platelets) in migraine platelets were also markedly increased (p <0.01 and p <0.001, respectively) when compared to controls (2.21 α 0.18 μg of GPIIb ano 18.75 λ 2.29 μE of fibrinogen per 108 platelets, respectively). There was a high correlation between the number of fibrinogen receptors exposed by ADP and the total amount of platelet GPIIb both in migraineurs (R = 0.69, p <0.01) and controls (R = 0.62, p <0.01,), as well as plasma cholesterol in the case of migraine patients (R = 0.82, p <0.001)

Keywords

Fibrinogen receptors - Glycoprotein IIb/IIIa complex - Cholesterol - Migraine
 

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