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Thromb Haemost 1978; 39(03): 712-724
DOI: 10.1055/s-0038-1646748
Original Article
Schattauer GmbH Stuttgart

Regulation of Carbohydrate Metabolism in Platelets

A Review
J W N Akkerman
The Dept. of Haematology, University Hospital, Utrecht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 21 June 1977

Accepted 12 December 1977

Publication Date:
12 July 2018 (online)

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  • References

  • 1 Aguilar J, Rosell-Pérez M. 1975; a Studies on glycogen metabolism in the human platelet. I Characteristics and regulation of the glycogen synthetase. Revista Espagñola de Fysiologica 31: 151
    PubMedGoogle Scholar
  • 2 Aguilar J, Rosell-Pérez M. 1975; b Studies on glycogen metabolism in the human platelet. II Metabolite levels and enzymes of the glycogen cycle. Revista Espagñola de Fysiologica 31: 163
    PubMedGoogle Scholar
  • 3 Akkerman JWN, Gorter G, Sixma JJ, Staal GEJ. 1974; a Human platelet 6-phosphofructokinase. Purification, kinetic parameters and the influence of sulphate ions on enzyme activity. Biochimica et biophysica acta 370: 102
    CrossrefPubMedGoogle Scholar
  • 4 Akkerman JWN, Gorter G, Sixma JJ, Staal GEJ. 1974; b Influence of Mg2+, ITP4- and ATP4- on human platelet phosphofructokinase. Biochimica et biophysica acta 370: 113
    CrossrefPubMedGoogle Scholar
  • 5 Akkerman JWN, Gorter G, Sixma JJ, Staal GEJ. 1974; c Influence of sulphate on effects of ADP, 3’,5’-cyclic AMP and citrate on human platelet phosphofructokinase activity. International Journal of Biochemistry 5: 853
    CrossrefPubMedGoogle Scholar
  • 6 Akkerman JWN, Gorter G, Over J, Sixma JJ, Staal GEJ. 1975; Human platelet 6-phosphofructokinase. Relation between inhibition by MgATP2- and cooperativity towards fructose-6-phosphate and investigations on the formation of a ternary complex. Biochimica et biophysica acta 397: 395
    CrossrefPubMedGoogle Scholar
  • 7 Akkerman JWN, Gorter G, Sixma JJ, Staal GEJ. 1976; a Variations in levels of glycolytic intermediates in human platelets during platelet-collagen interaction. Biochimica et biophysica acta 421: 296
    CrossrefPubMedGoogle Scholar
  • 8 Akkerman JWN, Gorter G, Wester J, Sixma JJ. 1976; b Preparation of concentrated platelet suspensions by dehydration against polyethyleneglycol 20.000. Scandinavian Journal of Haematology 17: 71
    PubMedGoogle Scholar
  • 9 Boiteux A, Goldberg A, Hess B. 1975; Control of oscillating glycolysis of yeast by stochastic, periodic, and steady source of substrate: a model and experimental study. Proceedings of the National Academy of Science USA 72: 3829
    CrossrefPubMedGoogle Scholar
  • 10 Brownen-Loder P, Hirsh J, De Gruchy GC. 1968; The effect of collagen on platelet glycolysis and nucleotide metabolism. British Journal of Haematology 14: 563
    CrossrefPubMedGoogle Scholar
  • 11 Chaiken R, Pagano D, Detwiler TC. 1975; Regulation of platelet phosphorylase. Biochimica et biophysica acta 403: 315
    CrossrefPubMedGoogle Scholar
  • 12 Chaudry AA, Sagone AL, Metz EN, Balcerzak SP. 1973; Relationship of glucose oxidation to aggregation of human platelets. Blood 41: 249
    PubMedGoogle Scholar
  • 13 Corn M. 1966; Effect of thrombin on glycolysis of fresh and stored platelets. Journal of Applied Physiology 21: 62
    CrossrefPubMedGoogle Scholar
  • 14 Cottreau D, Kahn A, Boivin P. 1976; Human platelet glucose-6-phosphate dehydrogenase. Total purification, kinetic studies and relationship with enzyme from other blood cells. Enzyme 21: 142
    CrossrefPubMedGoogle Scholar
  • 15 Cowan DH. 1973; Platelet metabolism in acute leukemia. Journal of Laboratory and Clinical Medicine 82: 54
    PubMedGoogle Scholar
  • 16 Czapek EE, Deykin D, Salzman EW. 1973; Platelet dysfunction in glycogen storage disease type I. Blood 41: 235
    PubMedGoogle Scholar
  • 17 Detwiler TC. 1969; Levels of intermediates and cofactors of the glycolytic pathway and the citric acid cycle in rat platelets. Biochimica et biophysica acta 177: 161
    CrossrefPubMedGoogle Scholar
  • 18 Detwiler TC, Zivkovic RV. 1970; Control of energy metabolism in platelets. A comparison of aerobic and anaerobic metabolism in washed rat platelets. Biochimica et biophysica acta 197: 117
    CrossrefPubMedGoogle Scholar
  • 19 Detwiler TC. 1971; Effects of deoxyglucose on platelet metabolism. Biochimica et biophysica acta 244: 303
    CrossrefPubMedGoogle Scholar
  • 20 Detwiler TC. 1972; Control of energy metabolism in platelets. The effects of thrombin and cyanide on glycolysis. Biochimica et biophysica acta 256: 163
    CrossrefPubMedGoogle Scholar
  • 21 Doery JCG, Hirsh J, Loder P, De Gruchy GC. 1967; Distribution of platelet hexokinase and the effect of collagen. Nature 216: 1317
    CrossrefPubMedGoogle Scholar
  • 22 Doery JCG, Hirsh J, Cooper I. 1970; a Energy metabolism in human platelets: interrelationship between glycolysis and oxidative metabolism. Blood 36: 159
    PubMedGoogle Scholar
  • 23 Doery JCG, Hirsh J, De Gruchy GC. 1970; b Platelet glycolytic enzymes: Effects of cellular disruption procedures on activity. British Journal of Haematology 19: 145
    CrossrefPubMedGoogle Scholar
  • 24 Doery JCG, Hirsh J, De Gruchy GC. 1970; c Platelet metabolism and function. Haematologica 4: 405
    PubMedGoogle Scholar
  • 25 Doery JCG, Hirsh J, Mustard JF. 1973; Energy metabolism in washed human platelets responsive to ADP: comparison with platelets in plasma. British Journal of Haematology 25: 657
    CrossrefPubMedGoogle Scholar
  • 26 Fukami MM, Salganicoff L, Bauer J. 1975 Pig platelet amylo-l,6-glucosidase – subcellular localization and possible activation by thrombin Vth Congress International Society on Thrombosis and Haemostasis. Paris 1975. Abstract no. 438
    PubMedGoogle Scholar
  • 27 Fukami MM, Holmsen H, Salganicoff L. 1976; Adenine nucleotide metabolism of blood platelets. IX Time course of secretion and changes in energy metabolism in thrombin-treated platelets. Biochimica et biophysica acta 444: 633
    CrossrefPubMedGoogle Scholar
  • 28 Gear ARL, Schneider W. 1975; Control of platelet glycogenolysis. Activation of phosphorylase kinase by calcium. Biochimica et biophysica acta 392: 111
    CrossrefPubMedGoogle Scholar
  • 29 Greenberg JH, Fletcher AP, Jamieson GA. 1973; The presence of glycogen synthase in preparations of platelet plasma membranes. Thrombosis et Diathesis Haemorrhagica 30: 307
    PubMedGoogle Scholar
  • 30 Gross R, Schneider W. 1971. Energy metabolism. In: Johnson SA. (ed.) The circulating platelet. Academic Press; New York: 123
    CrossrefGoogle Scholar
  • 31 Helleman PW, van Biervliet JPGM. 1975; Haematological studies in a new variant of glucosephosphate isomerase deficiency (GPI Utrecht). Helvetica paediatrica acta 30: 525
    PubMedGoogle Scholar
  • 32 Karpatkin S, Siskind GW. 1967; Effect of antibody binding and agglutination on human platelet glycolysis: comparison with thrombin and epinephrine. Blood 30: 617
    PubMedGoogle Scholar
  • 33 Karpatkin S, Braun J, Charmatz A. 1970; a Requirement of divalent cation for human platelet phosphorylase activity. Biochimica et biophysica acta 220: 22
    CrossrefPubMedGoogle Scholar
  • 34 Karpatkin S, Charmatz A. 1970; b Heterogeneity of human platelets. III Glycogen metabolism in platelets of different sizes. British Journal of Haematology 19: 135
    CrossrefPubMedGoogle Scholar
  • 35 Karpatkin S, Charmatz A, Langer RM. 1970; c Glycogenesis and glyconeogenesis in human platelets. Incorporation of glucose, pyruvate, and citrate into platelet glycogen; glycogen synthetase and fructose-1,6-diphosphatase activity. Journal of Clinical Investigation 49: 140
    CrossrefPubMedGoogle Scholar
  • 36 Kerby GP, Taylor SM. 1971; The influence of buffers on human platelet aggregation and energy metabolism. Proceedings of the Society of Experimental Biology and Medicine 136: 452
    PubMedGoogle Scholar
  • 37 Kim BK, Baldini MG. 1972; Glycolytic intermediates and adenine nucleotides of human platelets. II Effect of short-term storage at 4° C. Transfusion 12: 1
    CrossrefPubMedGoogle Scholar
  • 38 Kosow DP. 1974; Glucose 6-phosphate dehydrogenase of human blood platelets. Kinetics and regulatory properties. Archives in Biochemistry and Biophysics 162: 186
    CrossrefPubMedGoogle Scholar
  • 39 Kuramoto A, Steiner M, Baldini MG. 1970; Metabolic basis of platelet phagocytosis. Biochimica et biophysica acta 201: 471
    CrossrefPubMedGoogle Scholar
  • 40 Mcelroy FA, Kinlough-Rathbone RL, Ardlie NG, Packham MA, Mustard JF. 1971; The effect of aggregating agents on oxidative metabolism of rabbit platelets. Biochimica et biophysica acta 253: 64
    CrossrefPubMedGoogle Scholar
  • 41 Miller DR, Wollman MR. 1974; A new variant of glucose-6-phosphate dehydrogenase deficiency hereditary hemolytic anemia, G6PD Cornell: Erythrocyte, leukocyte and platelet studies. Blood 44: 323
    PubMedGoogle Scholar
  • 42 Minakami S. 1968; Studies on leukocyte metabolism. I Glycolytic intermediates and nucleotides in Guinea pig exudate granulocytes. Journal of Biochemistry 63: 83
    PubMedGoogle Scholar
  • 43 Nakamura N, Zuppinger KA, Colombo JP, Walter P. 1973; Synthesis of glucose in human thrombocytes. Metabolism 22: 29
    CrossrefPubMedGoogle Scholar
  • 44 Nakeff A, Ingram M. 1970; Platelet count: volume relationship in four mammalian species. Journal of Applied Physiology 28: 530
    CrossrefPubMedGoogle Scholar
  • 45 Newsholme EA, Start C. 1973. Regulation in metabolism. John Wiley; London:
    Google Scholar
  • 46 Niessner H, Beutler E. 1974; Fluorometric analysis of intermediates of the glycolytic and citric acid cycle pathway in human platelets. American Journal of Clinical Pathology 62: 361
    CrossrefPubMedGoogle Scholar
  • 47 Nishimura J, Minakami S. 1975; Effect of hydrogen ion concentration on energy metabolism in pig platelets. Biochimica et biophysica acta 396: 1
    CrossrefPubMedGoogle Scholar
  • 48 Pausescu E, Chirvasie R. 1973; Biochemical changes in the platelet energy transferring system during concomitant action of cephalin and serotonin. British Journal of Haematology 24: 605
    CrossrefPubMedGoogle Scholar
  • 49 Puszkin E, Aledort L, Puszkin S. 1970; The labeling of dicarboxylic amino acids and their amides by glucose and acetate in human platelets. Journal of Laboratory and Clinical Medicine 75: 234
    PubMedGoogle Scholar
  • 50 Rijksen G, Staal GEJ. 1977; Regulation of human erythrocyte hexokinase. Biochimica et biophysica acta 405: 75
    PubMedGoogle Scholar
  • 51 Schrijver J, Koster JF, HüLsman WC. 1975; Insignificance of gluconeogenesis in human platelets. European Journal of Clinical Investigation 5: 7
    CrossrefPubMedGoogle Scholar
  • 52 Schwartz JP, Cooperberg AA, Rosenberg A. 1974; Platelet-function studies in patients with glucose-6-phosphate dehydrogenase deficiency. British Journal of Haematology 27: 273
    CrossrefPubMedGoogle Scholar
  • 53 Scott RB. 1967; Activation of glycogen phosphorylase in blood platelets. Blood 30: 321
    PubMedGoogle Scholar
  • 54 Scott RB, Still WJS. 1970; Glycogen in human blood platelets. Isolation by ultra centrifugation and characteristics of the isolated particles. Blood 35: 517
    PubMedGoogle Scholar
  • 55 Sixma JJ, Akkerman JWN, Lips J, Holmsen H. 1977. Platelet energy metabolism. Proceedings 16th International Congress of Haematology. Excerpta Medica; Amsterdam:
    Google Scholar
  • 56 Solomon HM, Gaut ZN. 1970; Accumulationandmetabolismof2-deoxy-d-glucose-1-14C in the human platelet. Biochemical Pharmacology 19: 2631
    CrossrefPubMedGoogle Scholar
  • 57 Soyama K, Shimada N, Kusunoki T, Nakamura T. 1973; The diagnostic value of thrombocytic glucose-6-phosphatase in patients with von Gierke’s disease and its heterozygotes. Clinicachimica acta 44: 327
    PubMedGoogle Scholar
  • 58 Steiner M, Kuramoto A. 1971; Energy metabolism of aggregating platelets. Series Haematologica IV: 98
    PubMedGoogle Scholar
  • 59 Stjernholm RL, Larke RPB, Wheelock EF. 1971; Carbohydrate metabolism in the human platelet. Journal of Reticuloendothelial Society 10: 309
    PubMedGoogle Scholar
  • 60 Sugden PM, Newsholme EA. 1973; Activities of hexokinase, phosphofructokinase, 3-oxo acid coenzyme A-transferase and aceto acetyl-coenzyme A thiolase in nervous tissue from vertebrates and invertebrates. Biochemical Journal 134: 97
    CrossrefPubMedGoogle Scholar
  • 61 Vainer H, Besson P, Jeanneau C, Caen J. 1969; La glycogène-synthétase dans les plaquettes et les populations plaquettaires anormales de syndrome myéloprolifératifs. Nouvelle Revue Francais d’Hematologie 9: 514
    PubMedGoogle Scholar
  • 62 De Vreker GG, De Vreker RA. 1965; Aspects of platelet metabolism during aggregation. Revue Belge de Pathologie 31: 79
    PubMedGoogle Scholar
  • 63 Warshaw AL, Laster L, Schulman NK. 1969; The stimulation by thrombin of glucose oxidation in human platelets. Journal of Clinical Investigation 45: 1923
    PubMedGoogle Scholar
  • 64 Zieve PD, Schmukler M. 1974; Incorporation of carbohydrate into protein of human platelets. Biochimica et biophysica acta 372: 225
    CrossrefPubMedGoogle Scholar