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Thromb Haemost 1989; 62(02): 797-801
DOI: 10.1055/s-0038-1646906
Original Article
Schattauer GmbH Stuttgart

The Effect of n-3 Fatty Acids on Lipids and Haemostasis in Patients with Type lla and Type IV Hyperlipidaemia

E Berg Schmidt
1   The Department of Clinical Chemistry, Aalborg Hospital, Aalborg, Denmark
3   The Department of Geriatrics, Aalborg Hospital, Aalborg, Denmark
,
E Ernst
1   The Department of Clinical Chemistry, Aalborg Hospital, Aalborg, Denmark
,
K Varming
2   The Department of Clinical Immunology, Aalborg Hospital, Aalborg, Denmark
,
J O Pedersen
2   The Department of Clinical Immunology, Aalborg Hospital, Aalborg, Denmark
,
J Dyerberg
1   The Department of Clinical Chemistry, Aalborg Hospital, Aalborg, Denmark
› Author Affiliations
Further Information

Publication History

Received 28 December 1988

Accepted after revision 12 May 1989

Publication Date:
30 June 2018 (online)

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Summary

Plasma lipids and haemostasis were investigated in 17 patients with hyperlipidaemia before and after 6 weeks supplementation with 6 g n-3 fatty acids. Nine of the patients had type IIa and 8 had type IV hyperlipidaemia. No effect on plasma cholesterol, LDL- or HDL-cholesterol were seen, but plasma triglycerides decreased after n-3 supplementation. Apolipoprotein B increased and apolipoprotein A1 decreased after the oil supplement. The bleeding time was prolonged, but platelet aggregation was unaltered by n-3 fatty acids. Protein C activity increased in type II a and decreased in type IV after the supplement. Fibrinolysis was markedly depressed while von Willebrand factor antigen was reduced after intake of n-3 fatty acids.

Keywords

n-3 fatty acids - Fish oil - Lipids - Haemostasis - Fibrinolysis
 

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