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Thromb Haemost 1978; 40(01): 083-088
DOI: 10.1055/s-0038-1648637
Original Article
Schattauer GmbH Stuttgart

In Vivo Platelet Kinetics in 31 Diabetic Patients

Correlation with the Degree of Vascular Impairment
E Dassin
3   Attachée de Recherches à l’lnstitut National de la Santé et de la Recherche Médicale
,
Y Najean
1   The Service de Médecine Nucléaire, Hôpital Saint-Louis, 75010 Paris
,
O Poirier
1   The Service de Médecine Nucléaire, Hôpital Saint-Louis, 75010 Paris
,
Ph Passa
2   The Service de Nutrition et d’Endocrinologie, 75010 Paris, France
,
D Bensoussan
2   The Service de Nutrition et d’Endocrinologie, 75010 Paris, France
› Author Affiliations
Further Information

Publication History

Received 27 March 1977

Accepted 04 March 1978

Publication Date:
12 July 2018 (online)

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Summary

In vivo platelet survival was estimated, in 31 diabetic patients, using 51Cr-labelled autologous platelets. A mathematical analysis attempted to measure the “potential” life span (senescence process) and the degree of a superimposed aleatory destruction (consumption process).

The potential platelet life span in diabetics did not differ from normal values. However, excessive consumption was observed in one third of the studied cases, without correlation with the age of the patients, the clinical duration of diabetes, and the degree of vascular impairment. Thus, platelet kinetic studies did not provide presently useful indications, in a particular patient, regarding the prognosis of the vascular disease, and the justification of anti-aggregant therapy.

 

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