Download PDF
Thromb Haemost 1978; 40(01): 128-133
DOI: 10.1055/s-0038-1648642
Original Article
Schattauer GmbH Stuttgart

Smoking and Risk Factors in Deep Vein Thrombosis

R J Prescott
The Medical Computing and Statistics Unit, University of Edinburgh and Departments of Clinical Surgery and Medicine, Western General Hospital, Edinburgh, Great Britain
,
D R B Jones
The Medical Computing and Statistics Unit, University of Edinburgh and Departments of Clinical Surgery and Medicine, Western General Hospital, Edinburgh, Great Britain
,
C Vasilescu
The Medical Computing and Statistics Unit, University of Edinburgh and Departments of Clinical Surgery and Medicine, Western General Hospital, Edinburgh, Great Britain
,
J T Henderson
The Medical Computing and Statistics Unit, University of Edinburgh and Departments of Clinical Surgery and Medicine, Western General Hospital, Edinburgh, Great Britain
,
C V Ruckley
The Medical Computing and Statistics Unit, University of Edinburgh and Departments of Clinical Surgery and Medicine, Western General Hospital, Edinburgh, Great Britain
› Author Affiliations
Further Information

Publication History

Received 23 December 1977

Accepted 09 March 1978

Publication Date:
12 July 2018 (online)

  PDF Download  Permissions and Reprints

Summary

The incidence of deep vein thrombosis (DVT) as diagnosed by the 125I fibrinogen test (125IFT) was determined in a series of 300 newly admitted medical and 201 surgical patients. 6 medical patients died before 125IFT screening could be completed. The incidence of DVT was l4% in medical patients and 18% in surgical patients. Increasing age, a malignant condition and a past history of thromboembolism all increased the risk of DVT. Increasing levels of cigarette smoking were found to be associated with a reduced incidence of DVT. Although statistical significance was achieved at only the 10% level for this finding it is in agreement with the results from studies on patients with myocardial infarction. The protective effect of cigarette smoking was observed at all ages, and in both medical and surgical patients.

 

  • References

  • 1 Burn JH. 1952. Practical Pharmacology. Blackwell; Oxford:
    Google Scholar
  • 2 Cellina GU, Honour AJ, Littler WA. 1975; Direct arterial pressure, heart rate, and electrocardiogram during cigarette smoking in unrestricted patients. American Heart Journal 89: 18
    CrossrefPubMedGoogle Scholar
  • 3 Corre E, Lellouch J, Schwartz D. 1971; Smoking and leukocyte counts. Lancet 2: 632
    PubMedGoogle Scholar
  • 4 Cox DR. 1970. Analysis of Binary Data. Methuen, London:
    Google Scholar
  • 5 Edinburgh Multi-Unit Controlled Trial. 1974; Heparin versus Dextran in the prevention of deep vein thrombosis: a multi-unit controlled trial. Lancet 2: 118
    PubMedGoogle Scholar
  • 6 Flanc C, Kakkar VV, Clarke MB. 1968; The detection of venous thrombosis of the legs using 125I-labelled fibrinogen. British Journal of Surgery 55: 742
    CrossrefPubMedGoogle Scholar
  • 7 Handley AJ, Teather D. 1974; Influence of smoking on deep vein thrombosis after myocardial infarction. British Medical Journal 2: 230
    CrossrefPubMedGoogle Scholar
  • 8 Hills NH. et al 1972; Prevention of deep vein thrombosis by intermittent pneumatic compression of calf. British Medical Journal 1: 131
    CrossrefPubMedGoogle Scholar
  • 9 Howell RW. 1970; Smoking habits and laboratory tests. Lancet 2: 152
    PubMedGoogle Scholar
  • 10 International Multicentre Trial. 1975; Prevention of fatal postoperative pulmonary embolism by low doses of heparin: an international multicentre trial. Lancet 2: 45
    PubMedGoogle Scholar
  • 11 Ludbrook J, Vincent AH, Walsh JA. 1974; The effect of sham smoking and tobacco smoking on hand blood flow. Australian Journal of Experimental Biology and Medical Science 52: 285
    CrossrefPubMedGoogle Scholar
  • 12 Marks P, Emerson PA. 1974; Increased incidence of deep vein thrombosis after myocardial infarction in non-smokers. British Medical Journal 3: 232
    CrossrefPubMedGoogle Scholar
  • 13 Ogston D, Bennett NB, Ogston CM. 1970; The influence of cigarette smoking on the plasma fibrinogen concentration. Atherosclerosis 11: 349
    CrossrefPubMedGoogle Scholar
  • 14 Okuna T. 1973; Smoking and blood changes. Journal of the American Medical Association 225: 1387
    PubMedGoogle Scholar
  • 15 Ochsner A. et al 1951; Thrombo-embolism: an analysis of cases at the Charity Hospital in New Orleans over a 12-year period. Annals of Surgery 134: 405
    CrossrefPubMedGoogle Scholar
  • 16 Sarin CL, Austin JC, Nickel WO. 1974; Effects of smoking on digital blood flow velocity. Journal of the American Medical Association 229: 1327
    CrossrefPubMedGoogle Scholar
  • 17 Seltzer CC. 1974; Effect of smoking on blood pressure. American Heart Journal 87: 558
    CrossrefPubMedGoogle Scholar
  • 18 Wasserman J. 1973; Cigarette smoking and secondary polycythemia. Journal of the American Medical Association 224: 1654
    PubMedGoogle Scholar