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Am J Perinatol 2018; 35(13): 1303-1307
DOI: 10.1055/s-0038-1649483
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Efficacy of Neutral Position Beractant Administration in Neonates

Karen Kovey
1   Department of Pharmacy, Mission Health System, Asheville, North Carolina
,
Kelsi Barnes
2   Department of Pharmacy, Children's Hospital of Wisconsin, Milwaukee, Wisconsin
,
Robert D. Beckett
3   College of Pharmacy, Natural and Health Sciences, Manchester University, Fort Wayne, Indiana
,
Melissa Rice
4   Neonatal Intensive Care Medicine, Parkview Women's and Children's Hospital, Fort Wayne, Indiana
› Author Affiliations
Further Information

Publication History

14 November 2017

28 March 2018

Publication Date:
07 May 2018 (online)

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Abstract

Objective The objective was to compare the efficacy and adverse effects of beractant administration in neonates via a single aliquot in a neutral position versus positioning the neonates on their left then right side and two aliquots administration.

Study Design This was a retrospective cohort chart review of neonates who were diagnosed with respiratory distress syndrome and received beractant during two 15-month periods between 2013 and 2015 and 2015 and 2016 to compare the change in the fraction of inspired oxygen (FiO2) 1 hour after beractant administration.

Results There were no differences in FiO2 1 hour after beractant between groups (p = 0.617). Adverse events and other comorbidities did not differ between the groups.

Conclusion Changing administration of beractant from two aliquots and positions to a neutral position resulted in no significant change in FiO2 and may be considered as an option for administration in neonates.

Keywords

neonate - beractant - surfactant - administration - outcome - safety
 

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