Heparin-induced Thrombocytopenia: Discrepancy between the Presence of IgG Cross-reacting In Vitro with Fraxiparine and Its Successful Clinical Use

• References

• 1 Aster RH. Heparin-induced thrombocytopenia and thrombosis. N Engl J Med 1995; 332: 1374-1376
• 2 Amiral J, Bridey F, Dreyfus M, Vissac AM, Fressinaud E, Wolf M, Meyer D. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 1992; 68: 95-96
• 3 Greinacher A, Amiral J, Dummel V, Vissac A, Kiefel V, Mueller-Eckardt C. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced activation test and platelet factor 4-heparin enzyme linked immunosorbent assay. Transfusion 1994; 34: 381-454
• 4 Visentin GP, Ford SE, Scott JP, Aster RH. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J Clin Invest 1994; 93: 81-88
• 5 Amiral J, Bridey F, Wolf M, Boyer-Neumann C, Fressinaud E, Vissac AM, Peynaud-Debayle E, Dreyfus M, Meyer D. Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. Thromb Haemost 1995; 73: 21-28
• 6 Chong BH, Ismail F, Cade J, Gallus AS, Gordon S, Chesterman CN. Heparin-induced thrombocytopenia: studies with a new low-molecular weight heparinoid, Org 10172. Blood 1989; 73: 1592-1596
• 7 Greinacher A, Michels I, Mueller-Eckardt C. Heparin-associated thrombocytopenia: the antibody is not heparin specific. Thromb Haemost 1992; 67: 545-549
• 8 Demers C, Ginsberg JS, Brill-Edwards P, Panju A, Warkentin TE, Anderson DR, Turner C, Kelton JG. Rapid anticoagulation using ancrod for heparin-induced thrombocytopenia. Blood 1991; 78: 2194-2197
• 9 Cadroy Y, Amiral J, Raynaud H, Brunei P, Mazaleyrat A, Sauer M, Sie P. Evolution of antibodies anti-PF4/heparin in a patient with a history of heparin-induced thrombocytopenia re-exposed to heparin. Thromb Haemost 1994; 72: 782-786
• 10 Patrassi GM, Luzzatto G. Heparin-induced thrombocytopenia with thrombosis of the aorta, iliac arteries and right axillary vein successfully treated by low-molecular weight heparin. Acta Haematol 1994; 91: 55-56
• 11 Ortel TL, Gockerman JP, Califf RM, McCann RL, O’Connor CM, Metzler DM, Greenberg CS. Parenteral anticoagulation with the heparinoid Lomo-paran (Org 10172) in patients with heparin induced thrombocytopenia and thrombosis. Thromb Haemost 1992; 67: 292-296
• 12 Fabris F, Cordiano I, Salvan F, Saggin L, Celia G, Luzzatto G, Girolami A. Heparin-induced thrombocytopenia and thrombosis: prevalence in a large cohort of patients and evidence that PF4/heparin complex is the main antigen for antibodies. Submitted for publication
• 13 Greinacher A, Potzsch B, Amiral J, Dummel V, Eicher A, Mueller-Eckardt C. Heparin-associated thrombocytopenia: isolation of the antibody and characterization of a multimolecular PF₄-heparin complex as the major antigen. Thromb Haemost 1994; 7: 247-251
• 14 Pernod G, Duret J, Pouzol P, Charlet JP, Skolka I, Peyrin JC, Kolodie L. Thrombopénie induite par l’heparine: discordance entre l’éfficacité clinique de l’énoxaparine et les test d’agrégation plaquettaire in vitro. Presse Med 1993; 22 (15) 737