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Thromb Haemost 1992; 68(02): 130-135
DOI: 10.1055/s-0038-1656337
Original Article
Schattauer GmbH Stuttgart

Fibrin Gel Network Characteristics and Coronary Heart Disease: Relations to Plasma Fibrinogen Concentration, Acute Phase Protein, Serum Lipoproteins and Coronary Atherosclerosis

Kamaran Fatah
1   The Departments of Clinical Chemistry and Blood Coagulation, Stockholm, Sweden
,
Anders Hamsten
2   Internal Medicine, Karolinska Hospital, Stockholm, Sweden
3   King Gustaf V Research Institute, Stockholm, Sweden
,
Birger Blombäck
4   Department of Blood Coagulation Research, Karolinska Institute, Stockholm, Sweden
5   New York Blood Center, New York, NY, U.S.A.
,
Margareta Blombäck
1   The Departments of Clinical Chemistry and Blood Coagulation, Stockholm, Sweden
› Author Affiliations
Further Information

Publication History

Received 06 September 1991

Accepted after revision 06 March 1992

Publication Date:
03 July 2018 (online)

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Summary

The native fibrin gel structure formed in vitro from plasma samples was examined by liquid permeation of the hydrated fibrin gel networks in 18 men who had suffered a myocardial infarction before the age of 45 years and in 20 control subjects. Patients with an elevated plasma fibrinogen concentration had a considerably lower fibrin gel porosity (permeability coefficient, K s) compared with patients with a normal plasma fibrinogen level and with controls. The calculated fiber mass-length ratio of the fibrin gel networks was decreased in both patient groups. Gel porosity differed markedly between individuals at a given plasma fibrinogen concentration. Fairly strong inverse correlations were found between plasma orosomucoid level on the one hand and K s (r = –0.617, p <0.01) or fiber mass-length ratio (r = –0.499, p <0.05) on the other. The low density lipoprotein (LDL) cholesterol concentration also correlated inversely with K s (r = –0.471, p <0.05) and fiber mass-length ratio (r = –.522, p <0.05). Significant inverse relations, which were independent of plasma fibrinogen and lipoprotein concentrations, were detected between K s (r = –.519, p <0.05) and calculated fiber mass-length ratio (r = –.723, p <0.001) and number and severity of coronary artery stenoses determined by angiography. A proneness to formation of tight, rigid and space-filling fibrin network structures with small pores thus appears to be associated with premature coronary artery disease.

 

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