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Hamostaseologie 1982; 02(04): 169-178
DOI: 10.1055/s-0038-1656580
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Schattauer GmbH

Therapeutische Beeinflussung und Sekundärprävention arteriosklerotischer Gefäßwandveränderungen

H. Mörl
1   Med. Univ.-Klinik (Ludolf-Krehl-Klinik) Heidelberg (Direktor: Prof. Dr. Dr. h. c. mult. G. Schettler)
,
C. Diehm
1   Med. Univ.-Klinik (Ludolf-Krehl-Klinik) Heidelberg (Direktor: Prof. Dr. Dr. h. c. mult. G. Schettler)
,
G. Schettler
1   Med. Univ.-Klinik (Ludolf-Krehl-Klinik) Heidelberg (Direktor: Prof. Dr. Dr. h. c. mult. G. Schettler)
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Publication Date:
04 July 2018 (online)

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  • LITERATUR

  • 1 Amery A. S., Julius S., Whitlock L. S. et al. Influence of hypertension on the hemodynamic response to exercise. Circulation 1967; XXXVI: 231.
    PubMedGoogle Scholar
  • 2 Armstrong M. L., Warner E. D., Conner W. E. Circ. Res. 1970; 27: 59.
    PubMedGoogle Scholar
  • 3 Armstrong M. L., Megan M. B. Circ. Res. 1972; 30: 675.
    PubMedGoogle Scholar
  • 4 Armstrong M. L., Megan M. B. Circ. 1972, 43. Suppl. 4; 41.
    PubMed
  • 5 Anitschkow N. Ed. E. V. Cowdry. Macmillan; New York: 1933: 271
  • 6 Aschoff L. Lectures in Pathology. Hoeber; New York: 1924
    Google Scholar
  • 7 Askew E. W., Barakat H., Kuhl G. L., Dohm G. L. Response of lipogenesis and fatty acid synthetase to physical training and exhaustive exercise in rats. Lipids 1975; 10: 491.
    CrossrefPubMedGoogle Scholar
  • 8 Barndt R., Blankenhorn D. H., Crawford D. W., Brooks S. H. Regression and progression of early femoral atherosclerosis in treated hyperlipoproteinemic patients. Ann. of intern. Med. 1977; 86: 139.
    PubMedGoogle Scholar
  • 9 Beitzke H. Virchows. Arch. Path. Anat. 1928; 267: 625.
    CrossrefPubMedGoogle Scholar
  • 10 Berg A., Ringwald G., Keul J. Lipoprotein-Cholesterin in Abhängigkeit von Sportdisziplin und maximaler Sauerstoffaufnahme Deutscher Sportärztekongreß 1980. Saarbrücken, Demeter-Verlag; Gräfel-fing: 1980
    Google Scholar
  • 11 Beta-Blocker Heart Attack Trial Research Group. A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. J. Amer. Med. Ass. March 26 1982
    PubMed
  • 12 Bierenbaum M. L., Fleischmann A. I., Raichel-son R. I., Hayton T. H., Watson P. B. Lancet. 1973 1404
    PubMedGoogle Scholar
  • 13 Björntorp P., Berchtold P., Grimby G., Lindholm B., Sanne H., Tiblin G., Wilhelmsen L. Effects of physical training on glucose tolerance plasma insulin and lipids and on body composition in men after myocardial infarction. Acta Med. Scand. 1972; 192: 439.
    PubMedGoogle Scholar
  • 14 Blankenhorn D. H., Jankins C. D., Insull W., Weiss L. Type A physicians and coronary risk education. Ann. of intern. Med. 1974; 81: 700.
    PubMedGoogle Scholar
  • 15 Blankenhorn D. H., Barndt R., Crawford D. W., Selzer R., Beckenbach E. S. Prevalence and distribution of femoral atheromas in human hyperprotein-emia type II and IV. In: Atherosclerosis II (Eds. G. Schettler, A. Weizel). Springer Verlag Berlin Heidelberg; New York: 1974: 484.
    Google Scholar
  • 16 Blankenhorn D. H., Sanmarco M. E. Edito-rial: Angiography for study of lipid lowering therapy. Circulation 1979; 59: 212.
    CrossrefPubMedGoogle Scholar
  • 17 Bollinger A. Funktionelle Angiologie. Thieme, Stuttgart 1979
    PubMedGoogle Scholar
  • 18 Bradley R. F. Cardiovascular disease. In Joslin's diabetes mellitus, S. 417 (Hrsg.) Marble A., White P., Bradley R. F., Krall L. F. Lea and Febiger, Philadelphia.: British Research Committee.; Lancet 1968 693
    Google Scholar
  • 19 Clarkson T. B., Bond M. B., Marzetta C. A., Bullock B. C. Approaches to the Study of Atherosclerosis Regression in Rhesus Monkeys: Interpretation of morphometric Measurements of coronary arteries. In: Atherosclerosis V Eds. M. Gotto, Jr. Louis, C. Smith, Barbara Allen Springer, Berlin, Heidelberg; New York: 1979: 739
    Google Scholar
  • 20 Calvy G., Gertler L. M. M., Cady L. D. Serum lipids and vigorous exercise. Circulation 1963; 28: 651.
    PubMed
  • 21 Carlson L. A., Moosfeldt F. Acute effects of prolonged heavy exercise on the concentration of plasma lipids and lipoprotein in man. Acta Physiol. Scand. 1964; 62: 51.
    CrossrefPubMedGoogle Scholar
  • 22 Castelli W. P. High density lipoproteins: a new understanding of cholesterol and risk. Amer. Heart. Association's Fourth Science Writers Forum, San Antonio, Texas, Januar 1977
    PubMedGoogle Scholar
  • 23 Choquette G., Ferguson R. J. Blood pressure in »borderline« hypertensives following physical training. Can. med. Ass. J. 1973; 108: 699.
    PubMedGoogle Scholar
  • 24 Constantinides P., Booth J., Carlson G. Arch. Path. 1960; 70: 712.
    PubMedGoogle Scholar
  • 25 Constantinides P. Die Bedeutung von Endothel und Blutplättchen in der Pathogenese der Atherosklerose. Triangel 1976; 15: 53.
    PubMedGoogle Scholar
  • 26 Constantinides P. Fibrous Plaques and Regression. In: Atherosclerosis - is it reversible? (Eds. G. Schettler, E. Stange, R. W. Wissler) Springer, Berlin, Heidelberg; New York: 47
    Google Scholar
  • 27 Cooper K. H., Pollock M. L., Martin R. P., White S. R., Lunnerud A. C., Jackson A. Physical fitness levels and selected coronary risk factors. A crossec-tional study. J. Amer. med. Ass. 1976; 236: 166.
    CrossrefPubMedGoogle Scholar
  • 28 Crawford D. W., Blankenhorn D. H. Quantitative studies of atherosclerotic plaque size in human subjects. Intern. Symposium: State of prevention and therapy in human arteriosclerosis and animal models. Rhein.-Westf. Akademie der Wissenschaften. Westdeutscher Verlag, S. 55. 1978
    PubMedGoogle Scholar
  • 29 Crawford D. W., Sanmarco M. E., Blankenhorn D. H. Spatial reconstruction of human femoral atheromas showing regression. Amer. J. Med. 1979; 66: 784.
    CrossrefPubMedGoogle Scholar
  • 30 Daoud A. S., Jaumolych J., Augustin J. M., Fritz K. E. Regression of Advanced Atherosclerotic Lesion in Swine. In: Atherosclerosis V (Eds.: M. Gotto, Jr., Louis, C. Smith, Barbara Allen). Springer, Berlin, Heidelberg; New York: 1979: 149.
    Google Scholar
  • 31 Diehm C., Mörl H., Wirth A., Wieland H., Hoffmann G., Tripke A., Oster P., Halhuber M. J., Schettler G. Der Einfluß eines vierwöchigen körperlichen Trainings auf die SerumHpoproteine bei Patienten mit Myokardinfarkt. In: Müller-Wiefei, H. (Hrsg.): Tagungsbericht der Angiol. Ges. Deutschlands, Österreichs und der Schweiz, Düsseldorf 1979 Verlag Witzstrock, Baden-Baden, Köln; New York: 1979: 323
    Google Scholar
  • 32 Diehm C., Zimmermann R., Mörl H., Harenberg J., Wirth A., Halhuber M. J., Böclin R., Michel D., Schettler G. Der Einfluß eines Ausdauertrainings auf Hämostase und fibrinolytische Aktivität bei Patienten mit ischämischer Herzkrankheit. In: Sportmedizin, W. Kindermann und W. Horst (Hrsg.): S. 341-348. Demeter Verlag; Gräfelfing: 1980
    Google Scholar
  • 33 Diehm C., Wirth A., Teuber H., Mörl H., Heuck C. C. Serumüpoprotein-Cholesterin unter akuter Belastung bei trainierten und untrainierten Personen. In: Thrombose und Atherogenese-Pathophy-siologie und Therapie der arteriellen Verschlußkrankheit Bein-Beckenvenen-Thrombose. In: Breddin K. (Hrsg.) Verlag G. Witzstrock Baden-Baden, Köln; New York: 1981
    Google Scholar
  • 34 Diehm C., Wirth A., Teuber H., Mörl H., Heuck C. C. Serumlipoproteincholesterin unter akuter körperlicher Belastung bei trainierten und untrainierten Personen. In: Breddin, K. (Hrsg.): Tagungsbericht der Dt. Ges. f. Angiologie, Frankfurt S. 380 1980 Witzstrock, Baden-Baden, Köln; New York: 1981
    Google Scholar
  • 35 Diehm C., Mörl H., Wirth A., Schettler G. Körperliches Training als Prophylaxe arteriosklerotischer Gefäßerkrankungen. Therapiewoche 1981; 35: 5363.
    PubMedGoogle Scholar
  • 36 Diehm C., Wirth A., Müller-Bühl U., Mörl H., Schettler G. Glukose- und Insulinstoffwechsel bei Patienten mit peripherer arterieller Verschlußkrankheit. Deutscher Angiologenkongreß Ulm 15.-18. Sept. 1982
    Google Scholar
  • 37 Eggen D. A., Strong J. P., Newman W. P., Catsulis C., Malcolm G. T., Kokatnur M. G. Lab. Invest. 1974; 31: 294.
    PubMedGoogle Scholar
  • 38 Enger S.C., Stromme S. B., Refsum H. E. High density lipoprotein cholesterol total cholesterol and triglycerides in serum after a single exposure to prolonged heavy exercise. Scand. J. clin. Lab. Invest. 1980; 40: 34.
    PubMedGoogle Scholar
  • 39 Ganda O. P. Pathogenesis of macrovascular disease in the human diabetic. Diabetes 1980; 29: 931.
    CrossrefPubMedGoogle Scholar
  • 40 Gay S., Balleisen L. Components of lesion and regression. In: Atherosclerosis - is it reversible? (Eds. G. Schettler, E. Stange, R. W. Wissler). Springer, Berlin, Heidelberg; New York: 1977: 35.
    Google Scholar
  • 41 Giertsen J.C. Acta path. microbiol. scand. 1966; 67: 305.
    PubMedGoogle Scholar
  • 42 Goodkin G. Mortality factors in diabetes. I. Occup. Med. 17: 716-721. 1975;
    PubMedGoogle Scholar
  • 43 Gresham G. A. Atherosklerose: ihre Ursache und potentielle Reversibilität. Triangel 15, 39 1976
    Google Scholar
  • 44 Greten H., Klose G., Schettler G. Die Beeinflussung erhöhter Blutfette. Dtsch. Ärzteblatt 1978: 1739-1744.
    PubMedGoogle Scholar
  • 45 Hartley L. H., Grimby G., Kilbom A., Nilson N. J., Astrand I., Bjure J., Ekblom B., Saltin B. Physical training in sedentary middle-aged and older men. III. Cardiac. output and gas exchanges at submaximal and maximal exercise. Scand. J. clin. Lab. Invest. 1969; 24: 355.
    PubMedGoogle Scholar
  • 46 Hess H. Regression of atherosclerosis in man. In: Atherosclerosis - is it reversible? (Eds. G. Schettler, E. Stange, R. W. Wissler). Springer, Berlin, Heidelberg; New York: 1977: 89
    Google Scholar
  • 47 Heyden S. In: »Präventive Kardiologie« aus der Studienreihe Boehringer, Mannheim 1981
    PubMed
  • 48 Hjalmarson A. et al. : Effect on mortality of metopro-lol in acute myocardial infarction. Lancet II: 823-827. 1981;
    PubMedGoogle Scholar
  • 49 Holloszy J. O., Skinner J. S., Toro G., Cureton T. K. Effects of a six month programm of endurance on the serum lipids of middle-aged men. Amer. J. Cardiol. 1964; 14: 753.
    CrossrefPubMedGoogle Scholar
  • 50 Horlick L., Kath L. N. J. Lab. clin. Med. 1949; 34: 1427.
    PubMedGoogle Scholar
  • 51 Howard A. Baboons and Regression. In: Atherosclerosis - is it reversible? (Eds. G. Schettler, E. Stange, R. W. Wissler). Springer Verlag, Berlin, Heidelberg; New York: 1977: 57
    Google Scholar
  • 52 Jahnecke J. Hochdruckkrankheit und Sport. In: Risikofaktor Hypertonic Studienreihe Boehringer, Mannheim S.214. 1974
    PubMed
  • 53 Kannel W. B., McGree D. L. National Institutes of Health. National Heart, Lung, and Blood Institute. Heart Disease Epidemiology Study, Framingham, MA, Diabetes and cardio-vascular risk factors: The Framingham Study. Circulation 1979; 59: 8.
    CrossrefPubMedGoogle Scholar
  • 54 Knight L., Scheibel R., Amplatz K. et al. :Radiographic appraisal of the Minnesota partial ileal bypass study. Surg. Form 1972; 23: 141.
    PubMedGoogle Scholar
  • 55 Koivisto V., Felig P. Effects of leg exercise on insulin absorption in diabetic patients. New Engl. J. Med. 1979; 289: 11.
    PubMedGoogle Scholar
  • 56 Kramsch D., Aspen A. J., Abramowitz B. M., Kreimendahl T., Hood W. B. Reduction of coronary atherosclerosis by moderate conditioning exercise in monkeys on an atherogenic diet. New. Engl. J. Med. 1981; 305: 483.
    CrossrefPubMedGoogle Scholar
  • 57 Lampman R. M., Santinga T. J., Hodge M. F., Block W. D., Flora J. D., Bassett D. R. Comparative effects of physical training and diet in normalizing serum lipids in men with type IV hyperlipoproteinemia. Circulation 1977; 55: 652.
    CrossrefPubMedGoogle Scholar
  • 58 Leren P. Circulation. 1970; 42: 935.
    PubMedGoogle Scholar
  • 59 Lewis S. et al.: Effects of physical activity on weight reduction in obese middleaged women. Amer. J. clin. Nutr. 1976; 29: 151.
    PubMedGoogle Scholar
  • 60 Lippmann R. L., Raskin P., Love T., Triebwasser J., Lecocq R., Schnure J. J. Glucose intolerance during decreased physical activity in man. Diabetes 1972; 21: 101.
    CrossrefPubMedGoogle Scholar
  • 61 Lohmann D., Liebold F., Heilmann W., Senges H., Pohl A. Diminished insuline response in highly trained athletes. Metabolism 1978; 27: 521.
    CrossrefPubMedGoogle Scholar
  • 62 Maruffo C. A., Portman O. W. J. Atheroscl. Res. 1968; 8: 237.
    PubMedGoogle Scholar
  • 63 Miller G. J., Miller N. E. Plasma high-density lipoprotein concentration and development of ischemic heart disease. Lancet I 1975; 16.
    PubMedGoogle Scholar
  • 64 Mörl H. Herzinfarkt. Springer Verlag, Berlin Heidelberg; New York: 1981
    Google Scholar
  • 65 Montgommery B. J. High plasma insulin levels a prime risk factor for heart disease. J. Amer. med. Ass. 1979; 24: 1665.
    PubMedGoogle Scholar
  • 66 Morris N. J., Crawford M. D. Coronary heart disease and physical activity work. Brit. med. J. 1958; 2: 1485.
    CrossrefPubMedGoogle Scholar
  • 67 Novak L. P. Physical activity and body composition of adolescent boys. J. Amer. med. Ass. 1966; 197: 89.
    PubMedGoogle Scholar
  • 68 Raab W. The nonvascular metabolic myocardial vulnerability factor in "coronary heart disease". Amer. Heart J. 1963; 66: 685.
    CrossrefPubMedGoogle Scholar
  • 69 Roos R. Atherosklerose: Die Rolle von Endothellä-sionen Proliferation, glatter Muskelzellen und Blutplättchenfaktoren. Triangel 1976; 15: 45.
    PubMedGoogle Scholar
  • 70 Rose G. A. Passivrauchen. Dtsch. Ärztebl. 1982; 30: 22.
    PubMedGoogle Scholar
  • 71 Sanders-Williams R., Logue E., Lewis J. L., Barton T., Stead N. W., Waalace A. G., Pizzo S. V. Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults. New Engl. J. Med. 1980; 18: 987.
    PubMedGoogle Scholar
  • 72 Sanmarco M. E., Brooks S. H., Blankenhorn D. H. Reproducibility of a consensus panel in the interpretation of coronary angiograms. Amer. Heart J. 1978; 96: 430.
    CrossrefPubMedGoogle Scholar
  • 73 Schettler G. Arteriosklerose - Ätiologie. Pathologie, Klinik und Therapie. Thieme; Stuttgart: 1961
    Google Scholar
  • 74 Schettler G. 6. Intern. Atherosklerose-Symposion. Berlin 1982
    PubMed
  • 75 Schoop W., Levy H. Lebenserwartung bei Männern mit peripherer arterieller Verschlußkrankheit. Lebensversicherungsmedizin 1982; 34: 98.
    PubMedGoogle Scholar
  • 76 Schlierf G. Gibt es eine Regression der Atherosklerose beim Menschen?. Triangel 1976; 15: 71.
    PubMedGoogle Scholar
  • 77 Skinner J. S., Holloszy J. O., Cureton T. K. Effects of programm of endurance exercise on physical work (Capacity and anthropometrie measurements of middle-aged men). Amer. J. Cardiol. 1964; 14: 141.
    PubMedGoogle Scholar
  • 78 Soman V. R., Koivisto V. A., Deiberg O., Feh P., deFronzo R. A. Increased insulin sensitivity and insulin finding after physical training. New Engl. Med. 1979; 301: 1200.
    CrossrefPubMedGoogle Scholar
  • 79 Stary H.C. Regression of early lesions in monkeys. In: Atherosclerosis - is it reversible? Eds. G. Schettler, E. Stange R. W. Wissler. Springer, Berlin, Heidelberg; New York: 1977: 51
    Google Scholar
  • 80 Stein Y., Stein O. Der Cholesterintransport aus isolierten Zellen und Gewebekultur. Triangel 1976; 15: 63.
    PubMedGoogle Scholar
  • 81 Stein Y., Stein O. Catabolism of VLDL and removal of cholesterol from intact cells. In: Atherosclerosis - is it reversible? Eds. G. Schettler, E. Stange, R. W. Wissler. Springer, Berlin, Heidelberg; New York: 1977: 63.
    Google Scholar
  • 82 Stout W. R. Blood Glucose and Atherosclerosis. Arteriosclerosis 1: 227-234. 1981;
    CrossrefPubMedGoogle Scholar
  • 83 Strandness jr. D. E.. In: Atherosclerosis III. Eds. G. Schettler, A. Weizel. Springer, Berlin Heidelberg; New York: 1974: 707
    Google Scholar
  • 84 Strong W. B. (ed.): Atherosclerosis: Its pediatric aspects. Grune and Stratton, New York San Francisco; London: 1977
  • 85 The Norwegian Multicenter Study Group. Timolol - in Mortality and reinfarction in patients surviving acute myocardial infarction. New Engl. J. Med. 304 1981: 801
    PubMed
  • 86 Thompson P. D., Cullinane E., Henderson L. D., Herbert P. N. Acute effects of prolonged exercise on serum lipids. Metabolism 1980; 29: 662.
    CrossrefPubMedGoogle Scholar
  • 87 Warren Ph. K., Palmer D., Dennis I., Goldberg M. A. Hematological changes during exercise. In: D. T. Lowenthal, K. Bherodwaja, W. M. Oaks (Hrsg): Therapeutics through exercise Grune & Stratton; New York: 1979
    Google Scholar
  • 88 Wirth A., Diehm C., Mayer H., Mörl H., Vogel I., Björntorp B., Schlierf G. Plasma-C-peptide and insulin in trained and untrained subjects. J. appl. Physiol. 50, 1981
    Google Scholar
  • 89 Wirth A., Schlierf G., Schettler G. Körperliche Aktivität und Fettstoffwechsel. Klin. Wschr. 1979; 57: 1195.
    CrossrefPubMedGoogle Scholar
  • 90 Wissler R. W., Vessellinovitch D. In: Atherosclerosis III Eds. G. Schettler, A. Weizel. Springer, Berlin, Heidelberg; New York: 1974: 747
    Google Scholar
  • 91 Wissler R. W. Risk factors und regression. In: Atherosclerosis - is it reversible? (Eds. G. Schettler, E. Stange, R. W. Wissler). Springer, Berlin, Heidelberg; New York: 1977
  • 92 Wolf S. Relative burdens of emotions and exercise upon the cardiovascular system. In: F. F. Rosen-baum, E. L. Belknap (Eds.): Work and the heart. S. 167. Paul B. Hoeber; New York: 1959
    Google Scholar
  • 93 Wolfram G. Nutr. Metabol. 1973; 15: 141.
    PubMedGoogle Scholar
  • 94 Wood P. D. Physical activity and heart disease prevention. In: Drews, J., H. Greten, G. Schettler (Hrsg): Changes of the medical panorama. As exemplified by coronary and circulatory disorders. Thieme; Stuttgart: 1978
    Google Scholar
  • 95 Zelis R., Mason D. T., Braunwald E., Levy R. I. J. clin. Invest. 1970; 49: 1007.
    CrossrefPubMedGoogle Scholar
  • 96 Zöllner N. Cholesterinspiegelsenkung - warum und womit? Dtsch. Ärztebl. 1979: 199-206.
    PubMedGoogle Scholar
  • 97 A multicentre International Study Improvement in prognosis of myocardial infarction by a long term beta-adrenoreceptor blockade using practolol. Brit. Med. J. 3 1975: 735
    PubMedGoogle Scholar