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Tierarztl Prax Ausg K Kleintiere Heimtiere 2018; 46(06): 416-425
DOI: 10.1055/s-0038-1677407
Für Studium und Praxis – For students and practitioners
Georg Thieme Verlag KG Stuttgart · New York

Einsatz mesenchymaler Stammzellen beim Hund

Use of mesenchymal stemcells in dogs
Andrea Meyer-Lindenberg
1   Chirurgische und Gynäkologische Kleintierklinik, Ludwig-Maximilians-Universität München
,
Tim Kilchling
1   Chirurgische und Gynäkologische Kleintierklinik, Ludwig-Maximilians-Universität München
› Author Affiliations
Further Information

Publication History

Eingegangen: 23 July 2018

Akzeptiert nach Revision: 29 October 2018

Publication Date:
18 January 2019 (online)

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Zusammenfassung

Mesenchymale Stammzellen (MSC) sind multipotente Zellen, die sich in verschiedene Zelltypen des Körpers differenzieren können, z. B. in osteogene, chondrogene, adipogene und myogene Richtungen. Die klinische Anwendung von Stammzellen stellt in der Humanmedizin ein seit Jahrzehnten etabliertes Verfahren dar. Auch in der Veterinärmedizin werden insbesondere beim Pferd schon seit längerem Therapien mit MSC durchgeführt. Seit ca. 15 Jahren findet dieses Verfahren auch beim Hund immer häufiger klinische Anwendung. Haupteinsatzgebiet sind hier Erkrankungen des Bewegungsapparats, vor allem Lahmheiten infolge osteoarthrotischer Veränderungen der großen Gelenke. Die Isolierung der MSC erfolgt in der Veterinärmedizin überwiegend aus dem Knochenmark oder dem Fettgewebe. Diese Arbeit gibt einen Überblick über Entnahmelokalisation, Gewinnung, Charakterisierung und Anwendungsmöglichkeiten von MSC in der Veterinärmedizin, insbesondere beim Hund. Dargestellt werden dabei die in der zugängli-chen Literatur beschriebenen Studien zur Therapie bei orthopädischen Erkrankungen des Hundes.

Summary

Mesenchymal stem cells (MSC) are multipotent cells, which are able to differentiate into various cell types of the body, as for example in osteogenic, chondrogenic, adipogenic and myogenic directions. In human medicine, the application of stem cells represents a well-established clinical procedure already applied for several decades. Addition-ally, in veterinary medicine, the stem-cell field is a rapidly growing sector for clinical use, particularly in horses. Recently, this treatment moda lity has also been commonly applied in dogs. The main field of application are diseases of the musculoskeletal system. Furthermore MSC are predominantly used for the treatment of lameness because of osteoarthritic changes of the large joints. In veterinary medicine, MSC are mainly isolated from bone marrow or adipose tissue. This artic le provides an overview of the removal site, isolation, characterisation and application of MSC. Moreover, studies available in the litera ture concerning the therapy of orthopaedic diseases in the dog using MSC are presented.

Schlüsselwörter

AD-MSC - BM-MSC - Osteoarthrose - Therapie

Key words

AD-MSC - BM-MSC - osteoarthritis - therapy
 

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