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Synthesis 2020; 52(01): 135-140
DOI: 10.1055/s-0039-1690214
DOI: 10.1055/s-0039-1690214
paper
Cs2CO3-Promoted C(sp2)–N Formation of Dimethyl Thiocarbamate-Protected Indoles Using Tetramethylthiuram Monosulfide (TMTM)
We thank the foundation support from National Natural Science Foundation of China (21302150), Science and Technology Department of Hubei (2019CFB596), Chen-Guang program from Hubei Association for Science and Technology, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University (KLSAOFM1810).Further Information
Publication History
Received: 15 September 2019
Accepted after revision: 30 September 2019
Publication Date:
15 October 2019 (online)
Abstract
An efficient and simple synthesis of 1-thiocarbamoylindoles is reported in which 1H-indoles react with tetramethylthiuram monosulfide (TMTM) to give a series of 1-thiocarbamoylindoles that were obtained in good to excellent yields. The procedure was promoted by Cs2CO3 under transition-metal-free conditions and gives a simple entry to protected indoles.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690214.
- Supporting Information
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