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Synthesis 2020; 52(01): 51-59
DOI: 10.1055/s-0039-1690728
DOI: 10.1055/s-0039-1690728
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POxAP Precatalysts and the Negishi Cross-Coupling Reaction
S.-Q. Tang’s Ph.D. scholarship was funded by the Ministry of Education of the People’s Republic of China, China Scholarship Council (Grant No. 201608310124).Further Information
Publication History
Received: 13 September 2019
Accepted after revision: 30 September 2019
Publication Date:
28 October 2019 (online)
Abstract
Recently developed for the Fukuyama reaction, post-oxidative addition precatalysts (POxAPs) are also very efficient in catalyzing Negishi cross-coupling reactions between organohalides and organozinc reagents. Using very low catalyst loadings, POxAPs show similar catalytic activities to those of classical precatalysts such as XPhos Pd G4 or PEPPSI-IPr, with turnover numbers of up to 93,000. POxAPs are easily prepared, are stable to air and moisture, tolerate a wide range of functional groups in the Negishi cross-coupling reaction and contribute advantageously to the arsenal of organic chemists in terms of Pd precatalysts.
Key words
Negishi cross-coupling - organohalides - organozinc reagents - palladium - precatalyst - POxAPSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0039-1690728.
- Supporting Information
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