Download PDF
Am J Perinatol 2021; 38(S 01): e33-e38
DOI: 10.1055/s-0040-1705136
Original Article

Growth from Birth to 30 months for Infants Born with Congenital Gastrointestinal Anomalies and Disorders

Katie M. Strobel
1   Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Mattel Children's Hospital at UCLA, Los Angeles, California
,
Isabell Purdy
1   Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Mattel Children's Hospital at UCLA, Los Angeles, California
,
Tahmineh Romero
2   Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California
,
Kara L. Calkins 
1   Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Mattel Children's Hospital at UCLA, Los Angeles, California
› Author Affiliations Funding K.M.S. received funding from Children's Discovery and Research Institute at the University of California Los Angeles.
› Further Information
    Permissions and Reprints

Abstract

Objective This study aimed to investigate growth among neonates with gastrointestinal disorders.

Study Design Inclusion criteria included neonates with gastroschisis, omphalocele, intestinal atresia, tracheoesophageal fistula, Hirschsprung's disease, malabsorption disorders, congenital diaphragmatic hernia, and imperforate anus born between 2010 and 2018. Anthropometrics were collected for the first 30 months, and a subgroup analysis was performed for gastroschisis infants.

Results In 61 subjects, 13% developed severe growth failure within the first month. One-, four-, and nine-month weight and length z-scores were less than birth weight in all infants (p < 0.05). In infants with gastroschisis, a similar pattern was observed for weight z-scores only (p < 0.05). From birth to 15 months, head circumference z-score increased over time in all infants (p = 0.001), while in gastroschisis infants, weight, length, and head circumference z-scores increased over time (p < 0.05).

Conclusion In a cohort of infants with gastrointestinal disorders, growth failure was followed by catch-up growth.

Keywords

growth - gastrointestinal - gastroschisis - neonates - nutrition

Authors' Contributions

K.M.S. and K.L.C. conceived and designed the study. K.M.S. acquired the data. K.M.S. and T.R. analyzed the data. K.M.S., I.P., T.R., and K.L.C. interpreted the data. K.M.S. drafted the manuscript. K.M.S., I.P., T.R., and K.L.C. critically reviewed and approved the manuscripts. All authors agree to be accountable for the work.




Publication History

Received: 13 December 2019

Accepted: 22 January 2020

Article published online:
13 March 2020

© 2020. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Giúdici L, Bokser VS, Maricic MA, Golombek SG, Ferrario CC. Babies born with gastroschisis and followed up to the age of six years faced long-term morbidity and impairments. Acta Paediatr 2016; 105 (06) e275-e280
    CrossrefPubMedGoogle Scholar
  • 2 Harris EL, Minutillo C, Hart S. et al. The long term physical consequences of gastroschisis. J Pediatr Surg 2014; 49 (10) 1466-1470
    CrossrefPubMedGoogle Scholar
  • 3 Henrich K, Huemmer HP, Reingruber B, Weber PG. Gastroschisis and omphalocele: treatments and long-term outcomes. Pediatr Surg Int 2008; 24 (02) 167-173
    CrossrefPubMedGoogle Scholar
  • 4 Hong CR, Zurakowski D, Fullerton BS, Ariagno K, Jaksic T, Mehta NM. Nutrition delivery and growth outcomes in infants with gastroschisis. JPEN J Parenter Enteral Nutr 2018; 42 (05) 913-919
    CrossrefPubMedGoogle Scholar
  • 5 South AP, Marshall DD, Bose CL, Laughon MM. Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis. J Perinatol 2008; 28 (10) 702-706
    CrossrefPubMedGoogle Scholar
  • 6 Adesanya OA, O'Shea TM, Turner CS, Amoroso RM, Morgan TM, Aschner JL. Intestinal perforation in very low birth weight infants: growth and neurodevelopment at 1 year of age. J Perinatol 2005; 25 (09) 583-589
    CrossrefPubMedGoogle Scholar
  • 7 Leeuwen L, Walker K, Halliday R, Karpelowsky J, Fitzgerald DA. Growth in children with congenital diaphragmatic hernia during the first year of life. J Pediatr Surg 2014; 49 (09) 1363-1366
    CrossrefPubMedGoogle Scholar
  • 8 Gischler SJ, Mazer P, Duivenvoorden HJ. et al. Interdisciplinary structural follow-up of surgical newborns: a prospective evaluation. J Pediatr Surg 2009; 44 (07) 1382-1389
    CrossrefPubMedGoogle Scholar
  • 9 Minutillo C, Rao SC, Pirie S, McMichael J, Dickinson JE. Growth and developmental outcomes of infants with gastroschisis at one year of age: a retrospective study. J Pediatr Surg 2013; 48 (08) 1688-1696
    CrossrefPubMedGoogle Scholar
  • 10 Plummer EA, Wang Q, Larson-Nath CM, Scheurer JM, Ramel SE. Body composition and cognition in preschool-age children with congenital gastrointestinal anomalies. Early Hum Dev 2019; 129: 5-10
    CrossrefPubMedGoogle Scholar
  • 11 Nair N, Merhar S, Wessel J, Hall E, Kingma PS. Factors that influence longitudinal growth from birth to 18 months of age in infants with gastroschisis. Am J Perinatol 2020; 37 (14) 1438-1445
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Ehrenkranz RA, Dusick AM, Vohr BR, Wright LL, Wrage LA, Poole WK. Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infants. Pediatrics 2006; 117 (04) 1253-1261
    CrossrefPubMedGoogle Scholar
  • 13 Poindexter BB, Langer JC, Dusick AM, Ehrenkranz RA. ; National Institute of Child Health and Human Development Neonatal Research Network. Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcome. J Pediatr 2006; 148 (03) 300-305
    CrossrefPubMedGoogle Scholar
  • 14 Raz S, DeBastos AK, Newman JB. et al. Physical growth in the neonatal intensive-care unit and neuropsychological performance at preschool age in very preterm-born singletons. J Int Neuropsychol Soc 2015; 21 (02) 126-136
    CrossrefPubMedGoogle Scholar
  • 15 Stephens BE, Walden RV, Gargus RA. et al. First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants. Pediatrics 2009; 123 (05) 1337-1343
    CrossrefPubMedGoogle Scholar
  • 16 van Dommelen P, van der Pal SM, Bennebroek Gravenhorst J, Walther FJ, Wit JM, van der Pal de Bruin KM. The effect of early catch-up growth on health and well-being in young adults. Ann Nutr Metab 2014; 65 (2-3): 220-226
    CrossrefPubMedGoogle Scholar
  • 17 Olsen IE, Groveman SA, Lawson ML, Clark RH, Zemel BS. New intrauterine growth curves based on United States data. Pediatrics 2010; 125 (02) e214-e224
    CrossrefPubMedGoogle Scholar
  • 18 Centers for Disease Control and Prevention. WHO growth standards are recommended for use in the US for infants and children 0 to 2 years of age. Published 2010. Accessed October 21, 2014 at: http://www.cdc.gov/growthcharts/who_charts.htm#TheWHOGrowthCharts
  • 19 Centers for Disease Control and Prevention. Clinical growth charts. Published 2009. Accessed October 21, 2014 at: http://www.cdc.gov/growthcharts/clinical_charts.htm
  • 20 Guibourdenche J, Berrebi D, Vuillard E. et al. Biochemical investigations of bowel inflammation in gastroschisis. Pediatr Res 2006; 60 (05) 565-568
    CrossrefPubMedGoogle Scholar
  • 21 De Onis M, Blossner M. WHO Database on Childhood Growth and Malnutrition. Geneva: World Health Organization; 1997
    Google Scholar
  • 22 Lusk LA, Brown EG, Overcash RT. et al; University of California Fetal Consortium. Multi-institutional practice patterns and outcomes in uncomplicated gastroschisis: a report from the University of California Fetal Consortium (UCfC). J Pediatr Surg 2014; 49 (12) 1782-1786
    CrossrefPubMedGoogle Scholar
  • 23 Goldberg DL, Becker PJ, Brigham K. et al. Identifying malnutrition in preterm and neonatal populations: recommended indicators. J Acad Nutr Diet 2018; 118 (09) 1571-1582
    CrossrefPubMedGoogle Scholar
  • 24 Cormack BE, Embleton ND, van Goudoever JB, Hay Jr WW, Bloomfield FH. Comparing apples with apples: it is time for standardized reporting of neonatal nutrition and growth studies. Pediatr Res 2016; 79 (06) 810-820
    CrossrefPubMedGoogle Scholar
  • 25 Belfort MB, Gillman MW, Buka SL, Casey PH, McCormick MC. Preterm infant linear growth and adiposity gain: trade-offs for later weight status and intelligence quotient. J Pediatr 2013; 163 (06) 1564-1569.e2
    CrossrefPubMedGoogle Scholar
  • 26 Neubauer V, Griesmaier E, Pehböck-Walser N, Pupp-Peglow U, Kiechl-Kohlendorfer U. Poor postnatal head growth in very preterm infants is associated with impaired neurodevelopment outcome. Acta Paediatr 2013; 102 (09) 883-888
    CrossrefPubMedGoogle Scholar
  • 27 Hijkoop A, IJsselstijn H, Wijnen RMH, Tibboel D, Rosmalen JV, Cohen-Overbeek TE. Prenatal markers and longitudinal follow-up in simple and complex gastroschisis. Arch Dis Child Fetal Neonatal Ed 2018; 103 (02) F126-F131
    CrossrefPubMedGoogle Scholar
  • 28 Pfister KM, Ramel SE. Linear growth and neurodevelopmental outcomes. Clin Perinatol 2014; 41 (02) 309-321
    CrossrefPubMedGoogle Scholar
  • 29 Singhal A. Long-term adverse effects of early growth acceleration or catch-up growth. Ann Nutr Metab 2017; 70 (03) 236-240
    CrossrefPubMedGoogle Scholar
  • 30 Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 1986; 33 (01) 179-201
    CrossrefPubMedGoogle Scholar