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J Neurol Surg A Cent Eur Neurosurg 2021; 82(01): 090-094
DOI: 10.1055/s-0040-1712464
Case Report

Fractionated Radiosurgical Treatment of Intracerebral Schwannoma: A Case Report and Literature Review

Alexey Tokarev
1   Radiosurgery Center, Sklifosovsky Research Institute of Emergency Care, Москва, Russian Federation
,
Viacheslav Rak 
1   Radiosurgery Center, Sklifosovsky Research Institute of Emergency Care, Москва, Russian Federation
,
Valentin Stepanov
1   Radiosurgery Center, Sklifosovsky Research Institute of Emergency Care, Москва, Russian Federation
,
Sergey Zuev
1   Radiosurgery Center, Sklifosovsky Research Institute of Emergency Care, Москва, Russian Federation
,
Olga Evdokimova
1   Radiosurgery Center, Sklifosovsky Research Institute of Emergency Care, Москва, Russian Federation
,
Olga Viktorova
1   Radiosurgery Center, Sklifosovsky Research Institute of Emergency Care, Москва, Russian Federation
,
Elizabeth Rozhnova
1   Radiosurgery Center, Sklifosovsky Research Institute of Emergency Care, Москва, Russian Federation
› Author Affiliations Funding No funding was received for this research.
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Abstract

Intracranial schwannomas (ICS) unrelated to the cranial nerves are extremely rare; around 70 cases have been reported worldwide. The available literature consists of case reports and small series that present variable characteristics distinguishing these lesions. Brain parenchyma schwannomas are typically benign tumors with currently unknown origins. Diagnosis of intraparenchymal schwannoma is almost never made preoperatively. The management of these tumors usually consists of gross total resection, chemotherapy, and radiotherapy in cases of recurrence. The authors present a case of fractionated Gamma Knife radiosurgical treatment of intracerebral schwannoma following partial microsurgical resection.

Keywords

Gamma Knife - radiosurgery - intracerebral schwannoma


Publication History

Received: 26 July 2019

Accepted: 02 December 2019

Article published online:
21 October 2020

© 2020. Thieme. All rights reserved.

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  • References

  • 1 Russels DS, Rubinstein LJ. Pathology of Tumors of the Nervous System. 5th ed. London: Edward Arnold; 1989: 776-777
    Google Scholar
  • 2 Mahore A, Ramdasi R, Chagla A, Tikeykar V. Intraconal optic sheath schwannoma: report of two cases. Br J Neurosurg 2019; 33 (01) 101-103
    CrossrefPubMedGoogle Scholar
  • 3 Fornaro R, Salerno A, Filip DC, Caratto E, Caratto M, Casaccia M. Schwannoma of the hypoglossal nerve: review of the literature based on an illustrative case. Mol Clin Oncol 2017; 7 (02) 288-294
    PubMedGoogle Scholar
  • 4 Khoo HM, Taki T. Periventricular intraparenchymal schwannoma: case report. Neurol Med Chir (Tokyo) 2012; 52 (08) 603-607
    CrossrefPubMedGoogle Scholar
  • 5 Auer RN, Budny J, Drake CG, Ball MJ. Frontal lobe perivascular schwannoma: case report. J Neurosurg 1982; 56 (01) 154-157
    CrossrefPubMedGoogle Scholar
  • 6 Barbosa MD, Rebelo O, Barbosa P, Gonçalves J, Fernandes R. Cystic intraventricular schwannoma: case report and review of the literature. Neurocirugia (Astur) 2001; 12 (01) 56-60
    CrossrefPubMedGoogle Scholar
  • 7 Ezura M, Ikeda H, Ogawa A, Yoshimoto T. Intracerebral schwannoma: case report. Neurosurgery 1992; 30 (01) 97-100
    CrossrefPubMedGoogle Scholar
  • 8 Scott WW, Koral K, Margraf LR, Klesse L, Sacco DJ, Weprin BE. Intracerebral schwannomas: a rare disease with varying natural history. J Neurosurg Pediatr 2013; 12 (01) 6-12
    CrossrefPubMedGoogle Scholar
  • 9 Guha D, Kiehl TR, Krings T, Valiante TA. Intracerebral schwannoma presenting as classic temporal lobe epilepsy. J Neurosurg 2012; 117 (01) 136-140
    Google Scholar
  • 10 Luo W, Ren X, Chen S, Liu H, Sui D, Lin S. Intracranial intraparenchymal and intraventricular schwannomas: report of 18 cases. Clin Neurol Neurosurg 2013; 115 (07) 1052-1057
    CrossrefPubMedGoogle Scholar
  • 11 Gupta A, Sharma D, Dhillon GS, Chhabra SS. Intracranial periventricular supratentorial intraparenchymal schwannoma. Surg Neurol Int 2016; 7 (Suppl. 40) S1013-S1015
    CrossrefPubMedGoogle Scholar
  • 12 Casadei GP, Komori T, Scheithauer BW, Miller GM, Parisi JE, Kelly PJ. Intracranial parenchymal schwannoma: a clinicopathological and neuroimaging study of nine cases. J Neurosurg 1993; 79 (02) 217-222
    CrossrefPubMedGoogle Scholar
  • 13 AlBatly AA, Zakzouk RS, Alhaidey AK. An atypical case of intracerebral schwannoma. Pan Afr Med J 2014; 18: 342
    CrossrefPubMedGoogle Scholar
  • 14 Ishihara M, Miyagawa-Hayashino A, Nakashima Y, Haga H, Takahashi JA, Manabe T. Intracerebral schwannoma in a child with infiltration along perivascular spaces resembling meningioangiomatosis. Pathol Int 2009; 59 (08) 583-587
    CrossrefPubMedGoogle Scholar
  • 15 Menkü A, Oktem IS, Kontaş O, Akdemir H. Atypical intracerebral schwannoma mimicking glial tumor: case report. Turk Neurosurg 2009; 19 (01) 82-85
    PubMedGoogle Scholar
  • 16 Khoo HM, Taki T. Periventricular intraparenchymal schwannoma: case report. Neurol Med Chir (Tokyo) 2012; 52 (08) 603-607
    CrossrefPubMedGoogle Scholar
  • 17 Ramos AA, Vega MA, Valencia HS, García JC, Perez VC. Intraparenchymal schwannoma involving the brainstem in a young woman. Pediatr Neurol 2013; 48 (06) 472-474
    CrossrefPubMedGoogle Scholar
  • 18 Tanaka M, Shibui S, Nomura K, Nakanishi Y, Hasegawa T, Hirose T. Malignant intracerebral nerve sheath tumor with intratumoral calcification: case report. J Neurosurg 2000; 92 (02) 338-341
    CrossrefPubMedGoogle Scholar
  • 19 Katoh M, Aida T, Imamura H. et al. Calcified vestibular schwannoma in the cerebellopontine angle. J Clin Neurosci 2007; 14 (12) 1207-1209
    CrossrefPubMedGoogle Scholar
  • 20 Louw D, Sutherland G, Halliday W, Kaufmann J. Meningiomas mimicking cerebral schwannoma. J Neurosurg 1990; 73 (05) 715-719
    CrossrefPubMedGoogle Scholar
  • 21 Feigin I, Ogata J. Schwann cells and peripheral myelin within human central nervous tissues: the mesenchymal character of Schwann cells. J Neuropathol Exp Neurol 1971; 30 (04) 603-612
    CrossrefPubMedGoogle Scholar
  • 22 Frim DM, Ogilvy CS, Vonsattal JP, Chapman PH. Is intracerebral schwannoma a developmental tumor of children and young adults? Case report and review. Pediatr Neurosurg 1992; 18 (04) 190-194
    CrossrefPubMedGoogle Scholar
  • 23 Singh R, Ansinelli H, Jenkins J, Davis J, Sharma S, Vargo JA. Stereotactic radiosurgery and fractionated stereotactic radiosurgery for vestibular schwannomas: a comparison of clinical outcomes from the RSSearch patient registry. J Radiosurg SBRT 2019; 6 (01) 19-26
    PubMedGoogle Scholar
  • 24 D'Astous M, Ho AL, Pendharkar A. et al. Stereotactic radiosurgery for non-vestibular cranial nerve schwanommas. J Neurooncol 2017; 131 (01) 177-183
    CrossrefPubMedGoogle Scholar
  • 25 Daniel RT, Tuleasca C, Rocca A. et al. The Changing Paradigm for the Surgical Treatment of Large Vestibular Schwannomas. J Neurol Surg B Skull Base 2018; 79 (Suppl. 04) S362-S370
    Article in Thieme ConnectPubMedGoogle Scholar
  • 26 Kirkpatrick JP, Soltys SG, Lo SS, Beal K, Shrieve DC, Brown PD. The radiosurgery fractionation quandary: single fraction or hypofractionation?. Neuro-oncol 2017; 19 (02) (Suppl. 02) ii38-ii49
    CrossrefPubMedGoogle Scholar
  • 27 Park HR, Lee JM, Park KW. et al. Fractionated Gamma Knife radiosurgery as initial treatment for large skull base meningioma. Exp Neurobiol 2018; 27 (03) 245-255
    Google Scholar