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Semin Neurol 2020; 40(05): 473-484
DOI: 10.1055/s-0040-1713926
Review Article

Development of the Autonomic Nervous System: Clinical Implications

Frances Lefcort
1   Department of Cell Biology and Neuroscience, Montana State University, Bozeman, Montana
› Author Affiliations Acknowledgments This work was supported by the following grants from the NIH: R01 NS 35768 and R01 DK117473.
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Abstract

Investigations of the cellular and molecular mechanisms that mediate the development of the autonomic nervous system have identified critical genes and signaling pathways that, when disrupted, cause disorders of the autonomic nervous system. This review summarizes our current understanding of how the autonomic nervous system emerges from the organized spatial and temporal patterning of precursor cell migration, proliferation, communication, and differentiation, and discusses potential clinical implications for developmental disorders of the autonomic nervous system, including familial dysautonomia, Hirschsprung disease, Rett syndrome, and congenital central hypoventilation syndrome.

Keywords

autonomic nervous system - normal development - familial dysautonomia - Rett syndrome


Publication History

Article published online:
14 September 2020

© 2020. Thieme. All rights reserved.

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