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Semin Neurol 2021; 41(01): 101-106
DOI: 10.1055/s-0040-1722640
Review Article

Stem Cell Treatment for Ischemic Stroke Recovery

Douglas Kondziolka
1   Department of Neurosurgery, NYU Langone Health, New York University, New York, NY
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Abstract

The role of cellular transplantation to promote functional recovery after stroke has been evaluated over the last two decades. Preclinical studies first established the potential for cultured neuronal cells derived from a teratocarcinoma cell line to be tested for safety and efficacy in the treatment of human stroke. In animal models of stroke that caused reproducible learning and motor deficits, injection of neuronal cells resulted in a return of learning behavior, retention time, and motor function. Clinical trials followed. Additional work with cells derived from a bone marrow neuroprogenitor line, fetal cortical stem cells, and other cell sources showed promise in preclinical studies and then these cells were tested in clinical studies. This report reviews the different biological repair approaches using cell implants, discusses clinical trial design and surgical methods, and the current state of research.

Keywords

stroke - stem cell - transplantation - neuroprogenitor


Publication History

Article published online:
27 January 2021

© 2021. Thieme. All rights reserved.

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