Facial Plast Surg 2022; 38(03): 240-244
DOI: 10.1055/s-0041-1735648
Original Research

Postoperative Pain and Opioid Use after Facial Feminization Surgery

1   Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California
,
Nikolas R. Block-Wheeler
1   Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California
,
Rijul Kshirsagar
1   Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California
,
Kathleyn Brandstetter
1   Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California
,
Andrew Kleinberger
1   Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California
,
Charles Shih
1   Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California
› Author Affiliations

Abstract

The objective of this study is to characterize surgical pain after facial feminization surgery (FFS) and delineate postoperative opioid usage. It is a retrospective cohort study. It was performed in a multicenter integrated health care system. Electronic medical records were reviewed for patient demographic characteristics, medical history, pain medication prescriptions, and responses to a postoperative pain survey. Student's t-test and the Mann–Whitney U-test were used for bivariate analysis. Fisher's exact tests were used for categorical data. Seventy-four patients who underwent FFS were included. The mean (standard deviation) reported “average” postoperative pain score was 4.3 (2.3) out of 10. A total of 58% of patients reported pain lasting 5 or fewer days after surgery. The severity and duration of postoperative pain was similar between patients who underwent partial-FFS or full-FFS. A total of 68% of patients required fewer than 15 opioid tablets. There were no significant differences in the quantity of opioids prescribed or used between patients who underwent partial-FFS or full-FFS. Older age and premorbid mood disorder did not correlate with greater severity/duration of pain or number of opioids used after surgery. Most patients required fewer than 15 opioid tablets after surgery and experienced less than a week of postoperative pain. Patients undergoing full-FFS did not appear to experience significantly greater pain than those undergoing fewer procedures. Older age and premorbid mood disorder were not predictors of worse pain outcomes or greater opioid utilization.



Publication History

Article published online:
16 September 2021

© 2021. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Kessler ER, Shah M, Gruschkus SK, Raju A. Cost and quality implications of opioid-based postsurgical pain control using administrative claims data from a large health system: opioid-related adverse events and their impact on clinical and economic outcomes. Pharmacotherapy 2013; 33 (04) 383-391
  • 2 Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet 2006; 367 (9522): 1618-1625
  • 3 Jiang X, Orton M, Feng R. et al. Chronic opioid usage in surgical patients in a large academic center. Ann Surg 2017; 265 (04) 722-727
  • 4 Meraj TS, Bresler A, Zuliani GF. Acute pain management following facial plastic surgery. Otolaryngol Clin North Am 2020; 53 (05) 811-817
  • 5 Patel S, Sturm A, Bobian M, Svider PF, Zuliani G, Kridel R. Opioid use by patients after rhinoplasty. JAMA Facial Plast Surg 2018; 20 (01) 24-30
  • 6 Gadkaree SK, Shaye DA, Occhiogrosso J, Lee LN. Association between pain and patient satisfaction after rhinoplasty. JAMA Facial Plast Surg 2019; 21 (06) 475-479
  • 7 Chou DW, Tejani N, Kleinberger A, Shih C. Initial facial feminization surgery experience in a multicenter integrated health care system. Otolaryngol Head Neck Surg 2020; 163 (04) 737-742
  • 8 Benotsch EG, Zimmerman R, Cathers L. et al. Non-medical use of prescription drugs, polysubstance use, and mental health in transgender adults. Drug Alcohol Depend 2013; 132 (1–2): 391-394
  • 9 Reisner SL, Poteat T, Keatley J. et al. Global health burden and needs of transgender populations: a review. Lancet 2016; 388 (10042): 412-436
  • 10 Keuroghlian AS, Reisner SL, White JM, Weiss RD. Substance use and treatment of substance use disorders in a community sample of transgender adults. Drug Alcohol Depend 2015; 152: 139-146
  • 11 Restar AJ, Jin H, Ogunbajo A. et al. Prevalence and risk factors of nonmedical prescription opioid use among transgender girls and young women. JAMA Netw Open 2020; 3 (03) e201015
  • 12 Ahrnsbrak R, Bose J, Hedden S, Lipari R, Eunice P-L. Key substance use and mental health indicators in the United States: results from the 2016 National Survey on Drug Use and Health. Substance Abuse and Mental Health Services Administration. Accessed January 11, 2021 at: https://www.samhsa.gov/data/sites/default/files/NSDUH-FFR1-2016/NSDUH-FFR1-2016.htm
  • 13 Glynn TR, van den Berg JJ. A systematic review of interventions to reduce problematic substance use among transgender individuals: a call to action. Transgend Health 2017; 2 (01) 45-59
  • 14 Michaelides A, Zis P. Depression, anxiety and acute pain: links and management challenges. Postgrad Med 2019; 131 (07) 438-444
  • 15 Ip HYV, Abrishami A, Peng PWH, Wong J, Chung F. Predictors of postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology 2009; 111 (03) 657-677
  • 16 Bicket MC, Long JJ, Pronovost PJ, Alexander GC, Wu CL. Prescription opioid analgesics commonly unused after surgery: a systematic review. JAMA Surg 2017; 152 (11) 1066-1071
  • 17 Premkumar A, Lovecchio FC, Stepan JG. et al. Characterization of opioid consumption and disposal patterns after total knee arthroplasty. Bone Joint J 2019; 101-B (7_Supple_C): 98-103
  • 18 Stokes SM, Kim RY, Jacobs A. et al. Home disposal kits for leftover opioid medications after surgery: do they work?. J Surg Res 2020; 245: 396-402
  • 19 Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: results from the 2019 National Survey on Drug Use and Health. Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration; 2020. Accessed January 21, 2021 at: https://www.samhsa.gov/data/
  • 20 Walker NJ, Jones VM, Kratky L, Chen H, Runyan CM. Hematoma risks of nonsteroidal anti-inflammatory drugs used in plastic surgery procedures: a systematic review and meta-analysis. Ann Plast Surg 2019; 82 (6S, Suppl 5): S437-S445
  • 21 Kelley BP, Bennett KG, Chung KC, Kozlow JH. Ibuprofen may not increase bleeding risk in plastic surgery: a systematic review and meta-analysis. Plast Reconstr Surg 2016; 137 (04) 1309-1316
  • 22 Chen T, Adamson PA. Comparison of ibuprofen and acetaminophen with codeine following cosmetic facial surgery. J Otolaryngol Head Neck Surg 2009; 38 (05) 580-586
  • 23 Torgerson C, Yoskovitch A, Cole AFD, Conrad K. Postoperative pain management with ketorolac in facial plastic surgery patients. J Otolaryngol Head Neck Surg 2008; 37 (06) 888-893
  • 24 Newberry CI, McCrary HC, Cerrati EW. The efficacy of oral celecoxib following surgical rhinoplasty. Facial Plast Surg Aesthet Med 2020; 22 (02) 100-104
  • 25 Aynehchi BB, Cerrati EW, Rosenberg DB. The efficacy of oral celecoxib for acute postoperative pain in face-lift surgery. JAMA Facial Plast Surg 2014; 16 (05) 306-309
  • 26 Aviram J, Samuelly-Leichtag G. Efficacy of cannabis-based medicines for pain management: a systematic review and meta-analysis of randomized controlled trials. Pain Physician 2017; 20 (06) E755-E796
  • 27 Abdallah FW, Hussain N, Weaver T, Brull R. Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis. Reg Anesth Pain Med 2020; 45 (07) 509-519