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Exp Clin Endocrinol Diabetes 2016; 124(07): 401-409
DOI: 10.1055/s-0042-100909
Article
© Georg Thieme Verlag KG Stuttgart · New York

A Diabetes-specific Oral Nutritional Supplement Improves Glycaemic Control in Type 2 Diabetes Patients

P. Mayr
1   Diabetology, Health Care Centre, Stockach, Germany
,
K. S. Kuhn
2   Medical Writing, Stuttgart, Germany
,
P. Klein
3   d.s.h. Statistical Services, Rohrbach, Germany
,
J. F. Stover
4   Fresenius Kabi Deutschland GmbH, Bad Homburg, Germany
,
E. A. Pestana
4   Fresenius Kabi Deutschland GmbH, Bad Homburg, Germany
› Author Affiliations
Further Information

Publication History

received 09 September 2015
revised 12 January 2016

accepted 13 January 2016

Publication Date:
06 April 2016 (online)

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Abstract

Aims: Reducing the intake of low molecular weight carbohydrates with artificial nutrition may lower glycaemic response in patients with diabetes. We evaluated effects of a diabetes-specific carbohydrate modified oral nutritional supplement (ONS) during 12 weeks administration in 40 elderly type 2 normal weight patients with diabetes with previous involuntary weight loss.

Methods: Prospective, randomised, double-blind, controlled trial. Patients ingested 2×200 ml/day diabetes-specific or isocaloric standard ONS (control) in addition to their regular diet. Parameters of glucose and lipid metabolism, functional and nutritional status were assessed at baseline, weeks 6 and 12.

Results: Postprandial glucose incremental area under the curve (iAUC0-240 min) was comparable between treatment groups on day 1 (467.9±268.4 vs. 505.1±206.1 mmol/l*min, n.s. – arithmetic means±standard deviation) and was significantly lower with the diabetes-specific ONS vs. controls in weeks 6 and 12 (355.2±115.8 vs. 634.9±205.9 and 364.9±153.1 vs. 743.4±202.7; both P<0.0001). Postprandial peak glucose was significantly lower with the diabetes-specific ONS vs. controls in weeks 6 and 12 (P<0.0001) and the decrease in HbA1c, (baseline to week 12) was markedly pronounced (P=0.028). There were no differences between groups in insulin, HOMA-IR, lipid parameters, nutritional and performance status. Body weight and body mass index (BMI) increased significantly over time in both groups.

Conclusions: Administration of a diabetes-specific ONS for 12 weeks reduced postprandial glycaemia after ingestion of the study treatment and improved long-term glycaemic control in elderly patients with type 2 diabetes and involuntary weight loss, thereby reducing their risk for diabetes-associated long-term complications.

Key words

oral nutritional supplement - diabetes mellitus type 2 - glycaemic control
 

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