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Int J Sports Med 2016; 37(06): 493-499
DOI: 10.1055/s-0042-102258
Orthopedics & Biomechanics
© Georg Thieme Verlag KG Stuttgart · New York

Enhancement of Polyethylene Terephthalate Artificial Ligament Graft Osseointegration using a Periosteum Patch in a Goat Model

Z. Dai
1   Department of Sports Medicine, Huashan Hospital Fudan University, Shanghai, China
3   Department of Orthopedics, The Second Affiliated Hospital of Fujian Medical University, Fuzhou, China
,
W. Bao
2   Department of PET Center, Huashan Hospital, Fudan University, Shanghai, China
,
S. Li
1   Department of Sports Medicine, Huashan Hospital Fudan University, Shanghai, China
,
H. Li
1   Department of Sports Medicine, Huashan Hospital Fudan University, Shanghai, China
,
J. Jiang
1   Department of Sports Medicine, Huashan Hospital Fudan University, Shanghai, China
,
S. Chen
1   Department of Sports Medicine, Huashan Hospital Fudan University, Shanghai, China
› Author Affiliations
Further Information

Publication History



accepted after revision 19 January 2016

Publication Date:
18 March 2016 (online)

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Abstract

The purpose of this study is to investigate whether a periosteum patch could enhance polyethylene terephthalate (PET) artificial ligament graft osseointegration in a bone tunnel. 12 female goats underwent ACL reconstruction with a PET artificial ligament graft in the right knees. Right knees in 6 goats were reconstructed with periosteum patch-enveloped PET grafts (Periosteum group) in the tibia bone tunnel, whereas the other 6 goats had no periosteum patch and served as the Control group. All the goats were sacrificed at 12 months after surgery. 3 tibial-graft complex samples in each group were harvested consecutively for microcomputed tomography (micro-CT) scan, magnetic resonance imaging (MRI) scan and histological evaluation. The other 3 tibial-graft complex samples in each group were harvested for biomechanical testing. The mean pull-out load of the Periosteum group (208±25 N) at 12 months was significantly higher than that of the Control group (107±13 N) (p=0.0044). According to the micro-CT scan, more new bone formation was observed at the graft-bone interface in the Periosteum group compared with the Control group. Furthermore, MRI showed that the Periosteum group appeared to have a better graft osseointegration within the bone tunnel compared with the Control group. Histologically, application of a periosteum patch induced more new bone and Sharpey’s fiber formation between the graft and bone tunnel compared with the controls. The study has shown that periosteum enveloping of the PET artificial ligament has a positive effect in the induction of artificial ligament osseointegration within the bone tunnel.

Key words

polyethylene terepthalate - periosteum - osseointegration - artificial ligament - ACL
 

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