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Aktuelle Neurologie 2016; 43(06): 372-379
DOI: 10.1055/s-0042-109973
Neues in der Neurologie
© Georg Thieme Verlag KG Stuttgart · New York

Neues zur Botulinum Neurotoxin A Therapie bei Spastik und fokaler Dystonie

Botulinum Neurotoxin A Treatment for Spasticity and Dystonia – What is New?
T. Bäumer
1   Institut für Neurogenetik, Bewegungsstörungen und Neuropsychiatrie bei Kindern und Erwachsenen, Universitätsklinikum Schleswig-Holstein – Campus Lübeck
,
K. Zeuner
2   Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein – Campus Kiel
› Author Affiliations
Further Information

Publication History

Publication Date:
19 August 2016 (online)

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Zusammenfassung

Die Injektion mit Botulinum Neurotoxin A ist fester Bestandteil in der Behandlung von Erkrankungen, welche mit einer fokalen Spastik oder Dystonie einhergehen. In den letzten Jahren hat es in Deutschland neue Zulassungen für die Behandlung der Armspastik unabhängig von der Ätiologie und auch für die Behandlung der Beinspastik nach einem Schlaganfall gegeben. Daher haben sich die therapeutischen Möglichkeiten im Rahmen der Zulassungen deutlich erweitert. Die Anwendung von pathoanatomischen Konzepten zur Behandlung der zervikalen Dystonie insbesondere der Injektion in kleinere und tiefer gelegene Muskeln wird erläutert. Andere Aspekte der Behandlung wie Injektionsintervalle oder die aktuell diskutierte Hochdosistherapie werden dargestellt.

Abstract

The treatment of diseases associated with spasticity and focal dystonia with injection of Botulinum Neurotoxin A is well established. During the past years, Botulinum Neurotoxin A was licensed in Germany for treatment of lower limb post-stroke spasticity and for upper limb spasticity of any etiological origin. Hence, the therapeutic possibilities with Botulinum Neurotoxin A have increased. In this study, new pathoanatomical concepts in the treatment of smaller or deeper located muscles in cervical dystonia will be discussed. Further aspects relevant for treatment such as high-dose therapy will be presented.

Schlüsselwörter

Botulinum Neurotoxin - Spastik - Dystonie - Therapie

Keywords

spasticity - dystonia - treatment - Botulinum Neurotoxin
 

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