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Planta Med 2017; 83(05): 482-491
DOI: 10.1055/s-0042-112225
Formulation and Delivery Systems of Natural Products
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Acronychiabaueri Analogue Derivative-Loaded Ultradeformable Vesicles: Physicochemical Characterization and Potential Applications

Martina Di Francesco   *
1   Department of Health Sciences, University of Catanzaro “Magna Graecia”, Catanzaro, Italy
,
Rosita Primavera   *
2   Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
,
Serena Fiorito
2   Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
,
Maria Chiara Cristiano
1   Department of Health Sciences, University of Catanzaro “Magna Graecia”, Catanzaro, Italy
,
Vito Alessandro Taddeo
2   Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
,
Francesco Epifano
2   Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
,
Luisa Di Marzio
2   Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
,
Salvatore Genovese
2   Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
,
Christian Celia
2   Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
3   Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA
› Author Affiliations
Further Information

Publication History

received 16 February 2016
revised 15 June 2016

accepted 06 July 2016

Publication Date:
19 August 2016 (online)

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Abstract

Elastic and ultradeformable liposomes were synthesized and physicochemically characterized to make suitable topical formulations for delivering the anti-inflammatory and anticancer compound 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid. The average sizes of elastic and ultradeformable liposomes are below 300 nm, while the size distribution and Z-potential are below 0.3 and − 25 mV, respectively. The presence of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid does not affect the physicochemical parameters of nanovesicles. Elastic and ultradeformable liposomes show a zero order release kinetic and are stable at room temperature for a long time with or without 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid. The ultradeformable liposomes are more deformable than elastic liposomes. These differences may depend on sodium cholate derivatives making nanoformulations. The 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid-loaded elastic and ultradeformable liposomes can provide innovative nanotherapeutics-based natural compounds for the potential treatment of cutanous inflammation.

Key words

Acronychiabaueri species - elastic liposomes - ultradeformable liposomes - ethosomes - transfersomes - deformability study

* These authors contributed equally to this work.


Supporting Information

 

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