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Klin Monbl Augenheilkd 2018; 235(05): 597-602
DOI: 10.1055/s-0042-121424
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Stellenwert neuer Untersuchungsmethoden des Tränenfilms in der Diagnostik des trockenen Auges: Tränenfilmosmolarität und Matrixmetalloproteinasen (MMP-9)

Significance of New Methods of Examining the Tear Film in Dry Eye Disease: Tear Film Osmolarity and Matrix Metalloproteinases (MMP-9)
M. Schargus
1   Augenklinik Schweinfurt-Gerolzhofen
2   Augenklinik, Universitätsklinikum Düsseldorf
,
G. Geerling
2   Augenklinik, Universitätsklinikum Düsseldorf
,
S. C. Joachim
3   Augenklinik, Ruhr-Universität Bochum
› Author Affiliations
Further Information

Publication History

eingereicht 14 October 2016

akzeptiert 02 November 2016

Publication Date:
01 February 2017 (online)

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Zusammenfassung

Die Keratoconjunctivitis sicca ist eine der häufigsten Diagnosen in der Augenheilkunde. Eine Vielzahl von subjektiven und objektiven Testverfahren mit ungenauen Grenzbereichen und unterschiedlich hohen Sensitivitäten und Spezifitäten erschwert die Diagnostik. Gerade geringe bis moderate pathologische Befunde können so fehldiagnostiziert werden. In den letzten Jahren haben sich durch die Entwicklung neuer, klinisch einfach einsetzbarer Diagnostikgeräte bspw. für die Analyse der Tränenfilmosmolarität oder der Matrixmetalloproteinasen (MMP-9) neue Optionen ergeben. Der Stellenwert der Tränenfilmosmolarität und der Bestimmung der MMP-9-Werte in der Diagnostik des trockenen Auges und seiner Subformen wird diskutiert und anhand publizierter Studienergebnisse objektiv zu bewerten versucht.

Abstract

Dry eye disease is one of the most common diagnoses in ophthalmology. A variety of subjective and objective test methods with imprecise limits and highly different sensitivities and specificities complicate the diagnosis. Especially mild to moderate pathological findings can be misdiagnosed. In recent years, new options have opened, through the development of new, clinical practicable diagnostic equipment, for example, for the analysis of tear film osmolarity or matrix metalloproteinases (MMP-9). The value of tear film osmolarity and determination of MMP-9 levels in the diagnosis of dry eye and its subtypes will be discussed and evaluated objectively, on the basis of published study results.

Schlüsselwörter

trockenes Auge - Diagnostik - Osmolarität

Key words

dry eye - diagnostics - osmolarity - MMP-9
 

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