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Semin Plast Surg 2022; 36(01): 033-042
DOI: 10.1055/s-0042-1743455
Review Article

The Role of Skin Substitutes in Acute Burn and Reconstructive Burn Surgery: An Updated Comprehensive Review

Alen Palackic
1   Department of Surgery, Division of Burn and Trauma Surgery, University of Texas Medical Branch, Galveston, Texas
2   Department of Surgery, Division of Plastic, Aesthetic and Reconstructive Surgery, Medical University of Graz, Graz, Austria
,
Robert P. Duggan
1   Department of Surgery, Division of Burn and Trauma Surgery, University of Texas Medical Branch, Galveston, Texas
,
Matthew S. Campbell
3   School of Medicine, University of Texas Medical Branch, Galveston, Texas
,
Elliot Walters
1   Department of Surgery, Division of Burn and Trauma Surgery, University of Texas Medical Branch, Galveston, Texas
,
Ludwik K. Branski
1   Department of Surgery, Division of Burn and Trauma Surgery, University of Texas Medical Branch, Galveston, Texas
,
Amina El Ayadi
1   Department of Surgery, Division of Burn and Trauma Surgery, University of Texas Medical Branch, Galveston, Texas
,
Steven E. Wolf
1   Department of Surgery, Division of Burn and Trauma Surgery, University of Texas Medical Branch, Galveston, Texas
› Author Affiliations Funding This study was funded by Remembering the 15 Burn Research and Education Endowment.
› Further Information
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Abstract

Burns disrupt the protective skin barrier with consequent loss of cutaneous temperature regulation, infection prevention, evaporative losses, and other vital functions. Chronically, burns lead to scarring, contractures, pain, and impaired psychosocial well-being. Several skin substitutes are available and replace the skin and partially restore functional outcomes and improve cosmesis. We performed a literature review to update readers on biologic and synthetic skin substitutes to date applied in acute and reconstructive burn surgery. Improvement has been rapid in the development of skin substitutes in the last decade; however, no available skin substitute fulfills criteria as a perfect replacement for damaged skin.

Keywords

burns - skin - total body surface area - epithelization - biologics - synthetic dressing


Publication History

Article published online:
12 April 2022

© 2022. Thieme. All rights reserved.

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  • References

  • 1 Yousef H, Alhajj M, Sharma S. Anatomy, Skin (Integument), Epidermis. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2022
    Google Scholar
  • 2 Kohlhauser M, Luze H, Nischwitz SP, Kamolz LP. Historical evolution of skin grafting—a journey through time. Medicina (Kaunas) 2021; 57 (04) 1-14
    PubMedGoogle Scholar
  • 3 Shpichka A, Butnaru D, Bezrukov EA. et al. Skin tissue regeneration for burn injury. Stem Cell Res Ther 2019; 10 (01) 94
    CrossrefPubMedGoogle Scholar
  • 4 Dai C, Shih S, Khachemoune A. Skin substitutes for acute and chronic wound healing: an updated review. J Dermatolog Treat 2020; 31 (06) 639-648
    CrossrefPubMedGoogle Scholar
  • 5 Moi AL, Haugsmyr E, Heisterkamp H. Long-term study of health and quality of life after burn injury. Ann Burns Fire Disasters 2016; 29 (04) 295-299
    PubMedGoogle Scholar
  • 6 Wasiak J, Cleland H. Burns: dressings. BMJ Clin Evid 2015; 2015: 1903
    PubMedGoogle Scholar
  • 7 Lee KC, Joory K, Moiemen NS. History of burns: the past, present and the future. Burns Trauma 2014; 2 (04) 169-180
    CrossrefPubMedGoogle Scholar
  • 8 Haddad AG, Giatsidis G, Orgill DP, Halvorson EG. Skin substitutes and bioscaffolds: temporary and permanent coverage. Clin Plast Surg 2017; 44 (03) 627-634
    PubMedGoogle Scholar
  • 9 Halim AS, Khoo TL, Mohd Yussof SJ. Biologic and synthetic skin substitutes: An overview. Indian J Plast Surg 2010; 43 (suppl): S23-S28
    CrossrefPubMedGoogle Scholar
  • 10 Kogan S, Halsey J, Agag RL. Biologics in acute burn injury. Ann Plast Surg 2019; 83 (01) 26-33
    CrossrefPubMedGoogle Scholar
  • 11 Jeschke MG, Pinto R, Kraft R. et al; Inflammation and the Host Response to Injury Collaborative Research Program. Morbidity and survival probability in burn patients in modern burn care. Crit Care Med 2015; 43 (04) 808-815
    CrossrefPubMedGoogle Scholar
  • 12 Glat PM, Davenport T. Current techniques for burn reconstruction: Using dehydrated human amnion/chorion membrane allografts as an adjunctive treatment along the reconstructive ladder. Ann Plast Surg 2017; 78 (2, suppl 1): S14-S18
    CrossrefPubMedGoogle Scholar
  • 13 Rudnicki PA, Purt B, True D, Siordia H, Lohmeier S, Chan RK. Single-stage composite skin reconstruction using a dermal regeneration template. Plast Reconstr Surg Glob Open 2020; 8 (02) e2622
    CrossrefPubMedGoogle Scholar
  • 14 Saffle JR. Closure of the excised burn wound: temporary skin substitutes. Clin Plast Surg 2009; 36 (04) 627-641
    CrossrefPubMedGoogle Scholar
  • 15 Moiemen NS, Lee KC. The role of alternative wound substitutes in major burn wounds and burn scar resurfacing. In: Capek KD, Zapata-Sirvent R, Huang TT. eds. Total Burn Care. Elsevier; 2018: 633-639.e1
    Google Scholar
  • 16 Middelkoop E, Sheridan RL. Skin substitutes and ‘the next level. In: Tracy Toliver-Kinsky T, Kobayashi M, Suzuki F, Sherwood ER. eds. Total Burn Care. Elsevier; 2018: 167-173.e2
    Google Scholar
  • 17 Pruitt Jr BA, Levine NS. Characteristics and uses of biologic dressings and skin substitutes. Arch Surg 1984; 119 (03) 312-322
    CrossrefPubMedGoogle Scholar
  • 18 Sheridan RL, Tompkins RG. Skin substitutes in burns. Burns 1999; 25 (02) 97-103
    CrossrefPubMedGoogle Scholar
  • 19 Jeschke MG, Finnerty CC, Shahrokhi S, Branski LK, Dibildox M. ABA Organization and Delivery of Burn Care Committee. Wound coverage technologies in burn care: novel techniques. J Burn Care Res 2013; 34 (06) 612-620
    PubMedGoogle Scholar
  • 20 Vloemans AFPM, Hermans MHE, van der Wal MBA, Liebregts J, Middelkoop E. Optimal treatment of partial thickness burns in children: a systematic review. Burns 2014; 40 (02) 177-190
    CrossrefPubMedGoogle Scholar
  • 21 Bondoc CC, Burke JF. Clinical experience with viable frozen human skin and a frozen skin bank. Ann Surg 1971; 174 (03) 371-382
    CrossrefPubMedGoogle Scholar
  • 22 Herndon DN. Perspectives in the use of allograft. J Burn Care Rehabil 1997; 18 (1 Pt 2, suppl 1): S6
    CrossrefPubMedGoogle Scholar
  • 23 Kagan RJ, Robb EC, Plessinger RT. Human skin banking. Clin Lab Med 2005; 25 (03) 587-605
    CrossrefPubMedGoogle Scholar
  • 24 Alexander JW, MacMillan BG, Law E, Kittur DS. Treatment of severe burns with widely meshed skin autograft and meshed skin allograft overlay. J Trauma 1981; 21 (06) 433-438
    PubMedGoogle Scholar
  • 25 Kesting MR, Wolff K-D, Hohlweg-Majert B, Steinstraesser L. The role of allogenic amniotic membrane in burn treatment. J Burn Care Res 2008; 29 (06) 907-916
    CrossrefPubMedGoogle Scholar
  • 26 Yang C, Xiong AB, He XC. et al. Efficacy and feasibility of amniotic membrane for the treatment of burn wounds: a meta-analysis. J Trauma Acute Care Surg 2021; 90 (04) 744-755
    CrossrefPubMedGoogle Scholar
  • 27 Mostaque AK, Rahman KBMA. Comparisons of the effects of biological membrane (amnion) and silver sulfadiazine in the management of burn wounds in children. J Burn Care Res 2011; 32 (02) 200-209
    CrossrefPubMedGoogle Scholar
  • 28 Branski LK, Herndon DN, Celis MM, Norbury WB, Masters OE, Jeschke MG. Amnion in the treatment of pediatric partial-thickness facial burns. Burns 2008; 34 (03) 393-399
    CrossrefPubMedGoogle Scholar
  • 29 Herndon DN, Branski LK. Contemporary methods allowing for safe and convenient use of amniotic membrane as a biologic wound dressing for burns. Ann Plast Surg 2017; 78 (2, suppl 1): S9-S10
    CrossrefPubMedGoogle Scholar
  • 30 Marvin JA, Heimbach DM, Engrav LH, Harnar TJ. Improved treatment of the Stevens-Johnson syndrome. Arch Surg 1984; 119 (05) 601-605
    CrossrefPubMedGoogle Scholar
  • 31 Haller HL, Blome-Eberwein SE, Branski LK. et al. Porcine Xenograft and epidermal fully synthetic skin substitutes in the treatment of partial-thickness burns: a literature review. Medicina (Kaunas) 2021; 57 (05) 432
    CrossrefPubMedGoogle Scholar
  • 32 Wasiak J, Cleland H, Campbell F, Spinks A. Dressings for superficial and partial thickness burns. Cochrane Database Syst Rev 2013; (03) CD002106
    PubMedGoogle Scholar
  • 33 Song IC, Bromberg BE, Mohn MP, Koehnlein E. Heterografts as biological dressings for large skin wounds. Surgery 1966; 59 (04) 576-583
    PubMedGoogle Scholar
  • 34 Alam K, Jeffery SLA. Acellular fish skin grafts for management of split thickness donor sites and partial thickness burns: a case series. Mil Med 2019; 184 (suppl 1): 16-20
    CrossrefPubMedGoogle Scholar
  • 35 Stone II R, Saathoff EC, Larson DA. et al. Accelerated wound closure of deep partial thickness burns with acellular fish skin graft. Int J Mol Sci 2021; 22 (04) 1-18
    CrossrefPubMedGoogle Scholar
  • 36 Salisbury RE, Wilmore DW, Silverstein P, Pruitt Jr BA. Biological dressings for skin graft donor sites. Arch Surg 1973; 106 (05) 705-706
    CrossrefPubMedGoogle Scholar
  • 37 Lazic T, Falanga V. Bioengineered skin constructs and their use in wound healing. Plast Reconstr Surg 2011; 127 (suppl 1): 75S-90S
    CrossrefPubMedGoogle Scholar
  • 38 Cassidy C, St Peter SD, Lacey S. et al. Biobrane versus duoderm for the treatment of intermediate thickness burns in children: a prospective, randomized trial. Burns 2005; 31 (07) 890-893
    CrossrefPubMedGoogle Scholar
  • 39 Bacha EA, Sheridan RL, Donohue GA, Tompkins RG. Staphylococcal toxic shock syndrome in a paediatric burn unit. Burns 1994; 20 (06) 499-502
    CrossrefPubMedGoogle Scholar
  • 40 Whitaker IS, Prowse S, Potokar TS. A critical evaluation of the use of Biobrane as a biologic skin substitute: a versatile tool for the plastic and reconstructive surgeon. Ann Plast Surg 2008; 60 (03) 333-337
    CrossrefPubMedGoogle Scholar
  • 41 Woodroof A, Phipps R, Woeller C. et al. Evolution of a biosynthetic temporary skin substitute: a preliminary study. Eplasty 2015; 15: e30
    PubMedGoogle Scholar
  • 42 Tang H, Lv G, Fu J. et al. An open, parallel, randomized, comparative, multicenter investigation evaluating the efficacy and tolerability of Mepilex Ag versus silver sulfadiazine in the treatment of deep partial-thickness burn injuries. J Trauma Acute Care Surg 2015; 78 (05) 1000-1007
    CrossrefPubMedGoogle Scholar
  • 43 Gee Kee EL, Kimble RM, Cuttle L, Khan A, Stockton KA. Randomized controlled trial of three burns dressings for partial thickness burns in children. Burns 2015; 41 (05) 946-955
    CrossrefPubMedGoogle Scholar
  • 44 Aggarwala S, Harish V, Roberts S. et al. Treatment of partial thickness burns: a prospective, randomized controlled trial comparing four routinely used burns dressings in an ambulatory care setting. J Burn Care Res 2021; 42 (05) 934-943
    CrossrefPubMedGoogle Scholar
  • 45 Verbelen J, Hoeksema H, Heyneman A, Pirayesh A, Monstrey S. Aquacel(®) Ag dressing versus Acticoat™ dressing in partial thickness burns: a prospective, randomized, controlled study in 100 patients. Part 1: burn wound healing. Burns 2014; 40 (03) 416-427
    CrossrefPubMedGoogle Scholar
  • 46 Kaartinen IS, Kuokkanen HO. Suprathel(®) causes less bleeding and scarring than Mepilex(®) Transfer in the treatment of donor sites of split-thickness skin grafts. J Plast Surg Hand Surg 2011; 45 (4-5): 200-203
    CrossrefPubMedGoogle Scholar
  • 47 Schwarze H, Küntscher M, Uhlig C. et al. Suprathel, a new skin substitute, in the management of partial-thickness burn wounds: results of a clinical study. Ann Plast Surg 2008; 60 (02) 181-185
    CrossrefPubMedGoogle Scholar
  • 48 Uhlig C, Rapp M, Hartmann B, Hierlemann H, Planck H, Dittel K-K. Suprathel-an innovative, resorbable skin substitute for the treatment of burn victims. Burns 2007; 33 (02) 221-229
    CrossrefPubMedGoogle Scholar
  • 49 Hundeshagen G, Collins VN, Wurzer P. et al. A Prospective, randomized, controlled trial comparing the outpatient treatment of pediatric and adult partial-thickness burns with Suprathel or Mepilex Ag. J Burn Care Res 2018; 39 (02) 261-267
    PubMedGoogle Scholar
  • 50 Tanner Jr JC, Shea Jr PC, Bradley WH, Vandeput JJ. Large-mesh skin grafts. Plast Reconstr Surg 1969; 44 (05) 504-506 DOI: 10.1097/00006534-196944050-00025.
    CrossrefPubMedGoogle Scholar
  • 51 Bloemen MCT, van Leeuwen MCE, van Vucht NE, van Zuijlen PPM, Middelkoop E. Dermal substitution in acute burns and reconstructive surgery: a 12-year follow-up. Plast Reconstr Surg 2010; 125 (05) 1450-1459
    CrossrefPubMedGoogle Scholar
  • 52 Gardien KLM, Middelkoop E, Ulrich MMW. Progress towards cell-based burn wound treatments. Regen Med 2014; 9 (02) 201-218
    CrossrefPubMedGoogle Scholar
  • 53 Ter Horst B, Chouhan G, Moiemen NS, Grover LM. Advances in keratinocyte delivery in burn wound care. Adv Drug Deliv Rev 2018; 123: 18-32
    CrossrefPubMedGoogle Scholar
  • 54 Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975; 6 (03) 331-343
    CrossrefPubMedGoogle Scholar
  • 55 Sheridan R. Closure of the excised burn wound: autografts, semipermanent skin substitutes, and permanent skin substitutes. Clin Plast Surg 2009; 36 (04) 643-651
    CrossrefPubMedGoogle Scholar
  • 56 Auxenfans C, Shipkov H, Bach C. et al. Cultured allogenic keratinocytes for extensive burns: a retrospective study over 15 years. Burns 2014; 40 (01) 82-88
    CrossrefPubMedGoogle Scholar
  • 57 Chrapusta A, Nessler MB, Drukala J, Bartoszewicz M, Mądry R. A comparative analysis of advanced techniques for skin reconstruction with autologous keratinocyte culture in severely burned children: own experience. Postepy Dermatol Alergol 2014; 31 (03) 164-169
    CrossrefPubMedGoogle Scholar
  • 58 Domaszewska-Szostek AP, Krzyżanowska MO, Czarnecka AM, Siemionow M. Local treatment of burns with cell-based therapies tested in clinical studies. J Clin Med 2021; 10 (03) 1-24
    CrossrefPubMedGoogle Scholar
  • 59 Paddle-Ledinek JE, Cruickshank DG, Masterton JP. Skin replacement by cultured keratinocyte grafts: an Australian experience. Burns 1997; 23 (03) 204-211
    CrossrefPubMedGoogle Scholar
  • 60 Sood R, Roggy D, Zieger M. et al. Cultured epithelial autografts for coverage of large burn wounds in eighty-eight patients: the Indiana University experience. J Burn Care Res 2010; 31 (04) 559-568
    CrossrefPubMedGoogle Scholar
  • 61 Wood FM, Giles N, Stevenson A, Rea S, Fear M. Characterisation of the cell suspension harvested from the dermal epidermal junction using a ReCell® kit. Burns 2012; 38 (01) 44-51
    CrossrefPubMedGoogle Scholar
  • 62 Gravante G, Di Fede MC, Araco A. et al. A randomized trial comparing ReCell system of epidermal cells delivery versus classic skin grafts for the treatment of deep partial thickness burns. Burns 2007; 33 (08) 966-972
    CrossrefPubMedGoogle Scholar
  • 63 Holmes Iv JH, Molnar JA, Carter JE. et al. A comparative study of the ReCell® device and autologous split-thickness meshed skin graft in the treatment of acute burn injuries. J Burn Care Res 2018; 39 (05) 694-702
    CrossrefPubMedGoogle Scholar
  • 64 Gerlach JC, Johnen C, McCoy E, Bräutigam K, Plettig J, Corcos A. Autologous skin cell spray-transplantation for a deep dermal burn patient in an ambulant treatment room setting. Burns 2011; 37 (04) e19-e23
    CrossrefPubMedGoogle Scholar
  • 65 Moustafa M, Bullock AJ, Creagh FM. et al. Randomized, controlled, single-blind study on use of autologous keratinocytes on a transfer dressing to treat nonhealing diabetic ulcers. Regen Med 2007; 2 (06) 887-902
    CrossrefPubMedGoogle Scholar
  • 66 Yannas IV, Burke JF. Design of an artificial skin. I. Basic design principles. J Biomed Mater Res 1980; 14 (01) 65-81
    CrossrefPubMedGoogle Scholar
  • 67 Heimbach DM, Warden GD, Luterman A. et al. Multicenter postapproval clinical trial of Integra dermal regeneration template for burn treatment. J Burn Care Rehabil 2003; 24 (01) 42-48
    CrossrefPubMedGoogle Scholar
  • 68 Zajíček R, Grossová I, Šuca H, Kubok R, Pafčuga I. Experience with Integra® at the Prague Burns Centre 2002–2016. Acta Chir Plast 2017; 59 (01) 18-26
    PubMedGoogle Scholar
  • 69 Branski LK, Herndon DN, Pereira C. et al. Longitudinal assessment of Integra in primary burn management: a randomized pediatric clinical trial. Crit Care Med 2007; 35 (11) 2615-2623
    CrossrefPubMedGoogle Scholar
  • 70 Lee LF, Porch JV, Spenler W, Garner WL. Integra in lower extremity reconstruction after burn injury. Plast Reconstr Surg 2008; 121 (04) 1256-1262
    CrossrefPubMedGoogle Scholar
  • 71 Hicks KE, Huynh MN, Jeschke M, Malic C. Dermal regenerative matrix use in burn patients: a systematic review. J Plast Reconstr Aesthet Surg 2019; 72 (11) 1741-1751
    CrossrefPubMedGoogle Scholar
  • 72 Dantzer E, Braye FM. Reconstructive surgery using an artificial dermis (Integra): results with 39 grafts. Br J Plast Surg 2001; 54 (08) 659-664
    CrossrefPubMedGoogle Scholar
  • 73 Lohana P, Hassan S, Watson SB. Integra™ in burns reconstruction: our experience and report of an unusual immunological reaction. Ann Burns Fire Disasters 2014; 27 (01) 17-21
    PubMedGoogle Scholar
  • 74 Stiefel D, Schiestl C, Meuli M. Integra Artificial Skin for burn scar revision in adolescents and children. Burns 2010; 36 (01) 114-120
    CrossrefPubMedGoogle Scholar
  • 75 Kosutic D, Beasung E, Dempsey M. et al. Single-layer Integra for one-stage reconstruction of scalp defects with exposed bone following full-thickness burn injury: a novel technique. Burns 2012; 38 (01) 143-145
    CrossrefPubMedGoogle Scholar
  • 76 Atherton DD, Tang R, Jones I, Jawad M. Early excision and application of MatriDerm with simultaneous autologous skin grafting in facial burns. Plast Reconstr Surg 2010; 125 (02) 60e-61e
    CrossrefPubMedGoogle Scholar
  • 77 Cervelli V, Brinci L, Spallone D. et al. The use of MatriDerm® and skin grafting in post-traumatic wounds. Int Wound J 2011; 8 (04) 400-405
    CrossrefPubMedGoogle Scholar
  • 78 Gore DC. Utility of acellular allograft dermis in the care of elderly burn patients. J Surg Res 2005; 125 (01) 37-41
    CrossrefPubMedGoogle Scholar
  • 79 Callcut RA, Schurr MJ, Sloan M, Faucher LD. Clinical experience with Alloderm: a one-staged composite dermal/epidermal replacement utilizing processed cadaver dermis and thin autografts. Burns 2006; 32 (05) 583-588
    CrossrefPubMedGoogle Scholar
  • 80 Munster AM, Smith-Meek M, Shalom A. Acellular allograft dermal matrix: immediate or delayed epidermal coverage?. Burns 2001; 27 (02) 150-153
    CrossrefPubMedGoogle Scholar
  • 81 Greenwood J, Schmitt BJ, Wagstaff MJ. Experience with a synthetic bilayer Biodegradable Temporising Matrix in significant burn injury. Burns Open 2018; 2: 17-34
    CrossrefPubMedGoogle Scholar
  • 82 Lo CH, Brown JN, Dantzer EJG. et al. Wound healing and dermal regeneration in severe burn patients treated with NovoSorb® Biodegradable Temporising Matrix: a prospective clinical study. Burns 2021; DOI: 10.1016/j.burns.2021.07.014.
    CrossrefPubMedGoogle Scholar
  • 83 Cheshire PA, Herson MR, Cleland H, Akbarzadeh S. Artificial dermal templates: a comparative study of NovoSorb™ Biodegradable Temporising Matrix (BTM) and Integra(®) Dermal Regeneration Template (DRT). Burns 2016; 42 (05) 1088-1096
    CrossrefPubMedGoogle Scholar
  • 84 Supp DM, Boyce ST. Engineered skin substitutes: practices and potentials. Clin Dermatol 2005; 23 (04) 403-412
    CrossrefPubMedGoogle Scholar
  • 85 Zelen CM, Serena TE, Gould L. et al. Treatment of chronic diabetic lower extremity ulcers with advanced therapies: a prospective, randomised, controlled, multi-centre comparative study examining clinical efficacy and cost. Int Wound J 2016; 13 (02) 272-282
    CrossrefPubMedGoogle Scholar
  • 86 Waymack P, Duff RG, Sabolinski M. The Apligraf Burn Study Group. The effect of a tissue engineered bilayered living skin analog, over meshed split-thickness autografts on the healing of excised burn wounds. Burns 2000; 26 (07) 609-619
    CrossrefPubMedGoogle Scholar
  • 87 Serena TE, Carter MJ, Le LT. et al. A multicenter, randomized, controlled clinical trial evaluating the use of dehydrated human amnion/chorion membrane allografts and multilayer compression therapy vs. multilayer compression therapy alone in the treatment. Wound Repair Regen 2014; 22 (06) 688-693
    CrossrefPubMedGoogle Scholar
  • 88 Zelen CM, Serena TE, Snyder RJ. A prospective, randomised comparative study of weekly versus biweekly application of dehydrated human amnion/chorion membrane allograft in the management of diabetic foot ulcers. Int Wound J 2014; 11 (02) 122-128
    CrossrefPubMedGoogle Scholar
  • 89 Reilly DA, Hickey S, Glat P, Lineaweaver WC, Goverman J. Clinical experience: using dehydrated human amnion/chorion membrane allografts for acute and reconstructive burn care. Ann Plast Surg 2017; 78 (2, suppl 1): S19-S26
    CrossrefPubMedGoogle Scholar
  • 90 Gibson ALF, Holmes IV JH, Shupp JW. et al. A phase 3, open-label, controlled, randomized, multicenter trial evaluating the efficacy and safety of StrataGraft® construct in patients with deep partial-thickness thermal burns. Burns 2021; 47 (05) 1024-1037
    CrossrefPubMedGoogle Scholar
  • 91 Jeschke MG, Finnerty CC, Shahrokhi S, Branski LK, Dibildox M. ABA Organization and Delivery of Burn Care Committee. Wound coverage technologies in burn care: novel techniques. J Burn Care Res 2013; 34 (06) 612-620
    CrossrefPubMedGoogle Scholar
  • 92 Haddad AG, Giatsidis G, Orgill DP, Halvorson EG. Skin substitutes and bioscaffolds. Clin Plast Surg 2017; 44 (03) 627-634
    CrossrefPubMedGoogle Scholar