Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53(04): 252-268
DOI: 10.1055/s-0043-104664
Topthema
CME-Fortbildung
Georg Thieme Verlag KG Stuttgart · New York

Periphere Regionalanästhesie ohne Komplikationen – Ein Traum wird wahr?!

Peripheral Regional Anesthesia Without Any Complications – a Dream Comes True?!
Thomas Wiesmann
,
Jens Döffert
,
Thorsten Steinfeldt
Further Information

Publication History

Publication Date:
09 May 2018 (online)

Zusammenfassung

Periphere Regionalanästhesieverfahren sind relativ sichere Verfahren der klinischen Anästhesie – dennoch können typische, meist transiente und selten sogar persistierende Komplikationen auftreten. Neben allgemeinen Komplikationen und Strategien zur Risikoreduktion widmet sich dieser Artikel akzidentellen Mitblockaden anderer nervaler Strukturen am Beispiel des Plexus brachialis. Ein Ausblick in die Zukunft informiert über selektivere Blockaden.

Abstract

Peripheral regional anesthesia procedures, such as femoral nerve block, are relatively safe procedures in clinical anesthesia. Nevertheless, it may lead to typical, usually transient and rarely even persistent complications. This article aims to highlight key aspects of complications in peripheral regional anesthesia and, in particular, strategies to reduce risk. Moreover, beside general complications, which might potentially occur in any peripheral nerve blockade (“bleeding/infection/nerve damage”), accidental co-blockades of other nerval structures are discussed using the example of the brachial plexus. In addition to the presentation of the possible complications, this article discusses improvements in the techniques during the last two decades. Due to the use of ultrasound, some side effects nowadays are supposed to occur less likely. An outlook into the future will inform the reader about improved or more selective blockages.

Kernaussagen
  • Schwere Komplikationen sind in der peripheren Regionalanästhesie glücklicherweise selten, häufig transienter Natur und extrem selten persistierend.

  • Infektiöse Komplikationen sind bei einzeitigen Verfahren eine absolute Rarität.

  • Kontinuierliche Techniken („Schmerzkatheter“) zeigen häufig eine bakterielle Kolonisation, bei sorgfältiger klinischer Verlaufsbeurteilung aber nur selten eine relevante infektiöse Komplikation.

  • Die Anwendung von Ultraschall reduziert die Raten an akzidentellen Gefäßpunktionen, Hämatomen und „Versagern“.

  • Ultraschalleinsatz führt bei vielen Lokalisationen zu einer vollständigeren Blockade als die alleinige Anwendung des Nervenstimulators. Vermutlich hat die Anwendung des Ultraschalls die peripheren RA-Verfahren zugleich deutlich sicherer gemacht. Nervenschäden treten allerdings auch bei ultraschallunterstützten Verfahren auf.

  • Perioperative Nervenschäden werden häufig durch Lagerung, Tourniquet oder chirurgisches Trauma, aber eben auch durch die Regionalanästhesie verursacht.

  • Nervenschäden sind vermutlich oft bedingt durch eine Kombination aus mechanischem Trauma (direktes oder indirektes Nadeltrauma), Minderperfusion des Nervs und neurotoxischen Nebenwirkungen (Lokalanästhetika) – insbesondere bei Patienten mit neuropathischen Vorerkrankungen.

 
  • Literatur

  • 1 Kozek-Langenecker SA, Fries D, Gütl M. et al. Locoregionale Anästhesie und gerinnungshemmende Medikation. Anaesthesist 2005; 54: 476-484
  • 2 Chelly JE, Clark LD, Gebhard RE. et al. Consensus of the Orthopedic Anesthesia, Pain, and Rehabilitation Society on the use of peripheral nerve blocks in patients receiving thromboprophylaxis. J Clin Anesth 2014; 26: 69-74
  • 3 Waurick K, Riess H, Van Aken H. et al. S1 Leitlinie. Rückenmarknahe Regionalanästhesien und Thromboseprophylaxe/antithrombotische Medikation. Anästh Intensivmed 2014; 55: 464-492
  • 4 Lewis SR, Price A, Walker KJ. et al. Ultrasound guidance for upper and lower limb blocks. Cochrane Database Syst Rev 2015; (09) CD006459
  • 5 Verenna AA, Alexandru D, Karimi A. et al. Dorsal scapular artery variations and relationship to the brachial plexus, and a related thoracic outlet syndrome case. J Brachial Plex Peripher Nerve Inj 2016; 11: e21-e28
  • 6 Steinfeldt T, Wiesmann T, Nimphius W. et al. Perineural hematoma may result in nerve inflammation and myelin damage. Reg Anesth Pain Med 2014; 39: 513-519
  • 7 Ugrenovic SZ, Jovanovic ID, Kovacevic P. et al. Similarities and dissimilarities of the blood supplies of the human sciatic, tibial, and common peroneal nerves. Clin Anat 2013; 26: 875-882
  • 8 Sites BD, Beach ML, Spence BC. et al. Ultrasound guidance improves the success rate of a perivascular axillary plexus block. Acta Anaesthesiol Scand 2006; 50: 678-684
  • 9 Strub B, Sonderegger J, Von Campe A. et al. What benefits does ultrasound-guided axillary block for brachial plexus anaesthesia offer over the conventional blind approach in hand surgery?. J Hand Surg Eur Vol 2011; 36: 778-786
  • 10 Capdevila X, Bringuier S, Borgeat A. Infectious risk of continuous peripheral nerve blocks. Anesthesiology 2009; 110: 182-188
  • 11 Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (RKI). Anforderungen an die Hygiene bei Punktionen und Injektionen. Bundesgesundheitsbl 2011; 54: 1135-1144
  • 12 Nseir S, Pronnier P, Soubrier S. et al. Fatal streptococcal necrotizing fasciitis as a complication of axillary brachial plexus block. Br J Anaesth 2004; 92: 427-429
  • 13 Neuburger M, Breitbarth J, Reisig F et al. [Complications and adverse events in continuous peripheral regional anesthesia Results of investigations on 3,491 catheters]. Anaesthesist 2006; 55: 33-40
  • 14 Bomberg H, Kubulus C, List F. et al. German Network for Regional Anaesthesia Investigators. Diabetes: a risk factor for catheter-associated infections. Reg Anesth Pain Med 2015; 40: 16-21
  • 15 Kerwat K, Schulz-Stübner S, Steinfeldt T. et al. Hygieneempfehlungen für die Regionalanäshhesie – Überarbeitete Handlungsempfehlung. Anästh Intensivmed 2015; 56: 34-40
  • 16 Centers for Disease Control and Prevention (CDC). Bacterial meningitis after intrapartum spinal anesthesia – New York and Ohio, 2008–2009. MMWR Morb Mortal Wkly Rep 2010; 59: 65-69
  • 17 Morin AM, Kerwat KM, Klotz M. et al. Risk factors for bacterial catheter colonization in regional anaesthesia. BMC Anesthesiol 2005; 5: 1
  • 18 Kerwat K, Eberhart L, Kerwat M. et al. Chlorhexidine gluconate dressings reduce bacterial colonization rates in epidural and peripheral regional catheters. Biomed Res Int 2015; 2015: 149785
  • 19 Hogan QH. Pathophysiology of peripheral nerve injury during regional anesthesia. Reg Anesth Pain Med 2008; 33: 435-441
  • 20 Sorenson EJ. Neurological injuries associated with regional anesthesia. Reg Anesth Pain Med 2008; 33: 442-448
  • 21 Neal JM, Bernards CM, Hadzic A. et al. ASRA Practice Advisory on Neurologic Complications in Regional Anesthesia and Pain Medicine. Reg Anesth Pain Med 2008; 33: 404-415
  • 22 Brull R, McCartney CJ, Chan VW. et al. Neurological complications after regional anesthesia: contemporary estimates of risk. Anesth Analg 2007; 104: 965-974
  • 23 Fredrickson MJ, Kilfoyle DH. Neurological complication analysis of 1000 ultrasound guided peripheral nerve blocks for elective orthopaedic surgery: a prospective study. Anaesthesia 2009; 64: 836-844
  • 24 Aitkenhead AR. Injuries associated with anaesthesia. A global perspective. Br J Anaesth 2005; 95: 95-109
  • 25 Aminoff MJ. Electrophysiologic testing for the diagnosis of peripheral nerve injuries. Anesthesiology 2004; 100: 1298-1303
  • 26 Eipe N, Padhi NR. Tourniquet palsy or residual block?. Anesth Analg 2005; 100: 903-904
  • 27 Jeng CL, Rosenblatt MA. Intraneural injections and regional anesthesia: the known and the unknown. Minerva Anestesiol 2011; 77: 54-58
  • 28 Sites BD, Brull R. Ultrasound guidance in peripheral regional anesthesia: philosophy, evidence-based medicine, and techniques. Curr Opin Anaesthesiol 2006; 19: 630-639
  • 29 Selander D, Dhunér KG, Lundborg G. Peripheral nerve injury due to injection needles used for regional anesthesia. An experimental study of the acute effects of needle point trauma. Acta Anaesthesiol Scand 1977; 21: 182-188
  • 30 Steinfeldt T, Nimphius W, Werner T. et al. Nerve injury by needle nerve perforation in regional anaesthesia: does size matter?. Br J Anaesth 2010; 104: 245-253
  • 31 Steinfeldt T, Nimphius W, Wurps M. et al. Nerve perforation with pencil point or short bevelled needles: histological outcome. Acta Anaesthesiol Scand 2010; 54: 993-999
  • 32 Selander D. Peripheral nerve injury caused by injection needles. Br J Anaesth 1993; 71: 323-325
  • 33 Steinfeldt T, Werner T, Nimphius W. et al. Histological analysis after peripheral nerve puncture with pencil-point or Tuohy needle tip. Anesth Analg 2011; 112: 465-470
  • 34 Steinfeldt T, Graf J, Schneider J. et al. Histological consequences of needle-nerve contact following nerve stimulation in a pig model. Anesthesiol Res Pract 2011; 2011: 591851
  • 35 Steinfeldt T, Poeschl S, Nimphius W. et al. Forced needle advancement during needle-nerve contact in a porcine model: histological outcome. Anesth Analg 2011; 113: 417-420
  • 36 Perez-Castro R, Patel S, Garavito-Aguilar ZV. et al. Cytotoxicity of local anesthetics in human neuronal cells. Anesth Analg 2009; 108: 997-1007
  • 37 Yang S, Abrahams MS, Hurn PD. et al. Local anesthetic Schwann cell toxicity is time and concentration dependent. Reg Anesth Pain Med 2011; 36: 444-451
  • 38 Werdehausen R, Fazeli S, Braun S. et al. Apoptosis induction by different local anaesthetics in a neuroblastoma cell line. Br J Anaesth 2009; 103: 711-718
  • 39 Bigeleisen PE, Chelly J. An unsubstantiated condemnation of intraneural injection. Reg Anesth Pain Med 2011; 36: 95
  • 40 Bigeleisen PE, Moayeri N, Groen GJ. Extraneural versus intraneural stimulation thresholds during ultrasound-guided supraclavicular block. Anesthesiology 2009; 110: 1235-1243
  • 41 Bigeleisen PE. Nerve puncture and apparent intraneural injection during ultrasound-guided axillary block does not invariably result in neurologic injury. Anesthesiology 2006; 105: 779-783
  • 42 Wiesmann T, Steinfeldt T, Exner M. et al. Intraneural injection of a test dose of local anesthetic in peripheral nerves – does it induce histological changes in nerve tissue?. Acta Anaesthesiol Scand 2017; 61: 91-98
  • 43 Kapur E, Vuckovic I, Dilberovic F. et al. Neurologic and histologic outcome after intraneural injections of lidocaine in canine sciatic nerves. Acta Anaesthesiol Scand 2007; 51: 101-107
  • 44 Steinfeldt T. Nervenschäden bei Regionalanästhesie – Nervenschäden bei peripheren Blockaden: Pathophysiologie und Ursachen. Anästhesiol Intensivmed Notfallmed Schmerzther 2012; 47: 328-334
  • 45 Baumann H, Biscoping J. Lokalanästhetika-Toxizität. Grundlagen und Vorgehen beim Zwischenfall. Anästh Intensivmed 2011; 52: 189-198
  • 46 Vasques F, Behr AU, Weinberg G. et al. A review of local anesthetic systemic toxicity cases since publication of the American Society of Regional Anesthesia Recommendations: to whom it may concern. Reg Anesth Pain Med 2015; 40: 698-705
  • 47 Barrington MJ, Kluger R. Ultrasound guidance reduces the risk of local anesthetic systemic toxicity following peripheral nerve blockade. Reg Anesth Pain Med 2013; 38: 289-297
  • 48 Volk T, Graf BM, Gogarten W. et al. Empfehlungen zur Lipidbehandlung bei der Intoxikation mit Lokalanästhetika. Anästh Intensivmed 2009; 50: 698-702
  • 49 Wiesmann T, Bornträger A, Steinfeldt T. et al. Deklaration von Helsinki zur Patientensicherheit in der Anästhesiologie: SOP zur Lokalanästhetika-Intoxikation. Anästhesiol Intensivmed Notfallmed Schmerzther 2013; 48: 32-35
  • 50 Memtsoudis SG, Danninger T, Rasul R. et al. Inpatient falls after total knee arthroplasty: the role of anesthesia type and peripheral nerve blocks. Anesthesiology 2014; 120: 551-563
  • 51 Ilfeld BM, Duke KB, Donohue MC. The association between lower extremity continuous peripheral nerve blocks and patient falls after knee and hip arthroplasty. Anesth Analg 2010; 111: 1552-1554
  • 52 Wasserstein D, Farlinger C, Brull R. et al. Advanced age, obesity and continuous femoral nerve blockade are independent risk factors for inpatient falls after primary total knee arthroplasty. J Arthroplasty 2013; 28: 1121-1124
  • 53 Dennis DA, Kittelson AJ, Yang CC. et al. Does tourniquet use in TKA affect recovery of lower extremity strength and function? A randomized trial. Clin Orthop Relat Res 2016; 474: 69-77
  • 54 Bendtsen TF, Moriggl B, Chan V. et al. The optimal analgesic block for total knee arthroplasty. Reg Anesth Pain Med 2016; 41: 711-719
  • 55 Bendtsen TF, Moriggl B, Chan V. et al. The optimal analgesic block for total knee arthroplasty. Surv Anesthesiol 2017; 61: 79-80
  • 56 Jaeger P, Zaric D, Fomsgaard JS. et al. Adductor canal block versus femoral nerve block for analgesia after total knee arthroplasty: a randomized, double-blind study. Reg Anesth Pain Med 2013; 38: 526-532
  • 57 Wiesmann T, Piechowiak K, Duderstadt S. et al. Continuous adductor canal block versus continuous femoral nerve block after total knee arthroplasty for mobilisation capability and pain treatment: a randomised and blinded clinical trial. Arch Orthop Trauma Surg 2016; 136: 397-406
  • 58 Kuang MJ, Xu LY, Ma JX. et al. Adductor canal block versus continuous femoral nerve block in primary total knee arthroplasty: A meta-analysis. Int J Surg 2016; 31: 17-24
  • 59 Urmey WF, Talts KH, Sharrock NE. One hundred percent incidence of hemidiaphragmatic paresis associated with interscalene brachial plexus anesthesia as diagnosed by ultrasonography. Anesth Analg 1991; 72: 498-503
  • 60 Al-Kaisy AA. Respiratory effects of low-dose bupivacaine interscalene block. Br J Anaesth 1999; 82: 217-220
  • 61 Urmey WF, McDonald M. Hemidiaphragmatic paresis during interscalene brachial plexus block: effects on pulmonary function and chest wall mechanics. Anesth Analg 1992; 74: 352-357
  • 62 Urmey WF, Gloeggler PJ. Pulmonary function changes during interscalene brachial plexus block: effects of decreasing local anesthetic injection volume. Reg Anesth 1993; 18: 244-249
  • 63 Hartrick CT, Tang YS, Siwek D. et al. The effect of initial local anesthetic dose with continuous interscalene analgesia on postoperative pain and diaphragmatic function in patients undergoing arthroscopic shoulder surgery: a double-blind, randomized controlled trial. BMC Anesthesiol 2012; 12: 6
  • 64 Lee JH, Cho SH, Kim SH. et al. Ropivacaine for ultrasound-guided interscalene block: 5 mL provides similar analgesia but less phrenic nerve paralysis than 10 mL. Can J Anaesth 2011; 58: 1001-1006
  • 65 Renes SH, van Geffen GJ, Rettig HC. et al. Minimum effective volume of local anesthetic for shoulder analgesia by ultrasound-guided block at root C7 with assessment of pulmonary function. Reg Anesth Pain Med 2010; 35: 529-534
  • 66 Stundner O, Meissnitzer M, Brummett CM. et al. Comparison of tissue distribution, phrenic nerve involvement, and epidural spread in standard- vs. low-volume ultrasound-guided interscalene plexus block using contrast magnetic resonance imaging: a randomized, controlled trial. Br J Anaesth 2016; 116: 405-412
  • 67 Wiesmann T, Feldmann C, Müller HH. et al. Phrenic palsy and analgesic quality of continuous supraclavicular vs. interscalene plexus blocks after shoulder surgery. Acta Anaesthesiol Scand 2016; 60: 1142-1151
  • 68 Koh WU, Park HS, Choi WJ. et al. A randomised controlled trial comparing continuous supraclavicular and interscalene brachial plexus blockade for open rotator cuff surgery. Anaesthesia 2016; 71: 692-699
  • 69 El-Boghdadly K, Chin KJ, Chan VW. Phrenic nerve palsy and regional anesthesia for shoulder surgery: anatomical, physiologic, and clinical considerations. Anesthesiology 2017; 127: 173-191
  • 70 Guo CW, Ma JX, Ma XL. et al. Supraclavicular block versus interscalene brachial plexus block for shoulder surgery: A meta-analysis of clinical control trials. Int J Surg 2017; 45: 85-91
  • 71 Wiegel M, Moriggl B, Schwarzkopf P. et al. Anterior suprascapular nerve block versus interscalene brachial plexus block for shoulder surgery in the outpatient setting. Reg Anesth Pain Med 2017; 42: 310-318
  • 72 Auyong DB, Yuan SC, Choi DS. et al. A double-blind randomized comparison of continuous interscalene, supraclavicular, and suprascapular blocks for total shoulder arthroplasty. Reg Anesth Pain Med 2017; 42: 302-309
  • 73 Fredrickson MJ, Krishnan S, Chen CY. Postoperative analgesia for shoulder surgery: a critical appraisal and review of current techniques. Anaesthesia 2010; 65: 608-624
  • 74 Perlas A, Lobo G, Lo N. et al. Ultrasound-guided supraclavicular block: outcome of 510 consecutive cases. Reg Anesth Pain Med 2009; 34: 171-176
  • 75 Yazer MS, Finlayson RJ, Tran DQ. A randomized comparison between infraclavicular block and targeted intracluster injection supraclavicular block. Reg Anesth Pain Med 2015; 40: 11-15
  • 76 Liu SS, Gordon MA, Shaw PM. et al. A prospective clinical registry of ultrasound-guided regional anesthesia for ambulatory shoulder surgery. Anesth Analg 2010; 111: 617-623
  • 77 Gollapalli L, McKelvey G, Wang H. Delayed vocal fold paralysis after continuous interscalene level brachial plexus block with catheter placement: a case report. J Clin Anesth 2014; 26: 407-409
  • 78 Kalvøy H, Sauter AR. Detection of intraneural needle-placement with multiple frequency bioimpedance monitoring: a novel method. J Clin Monit Comput 2016; 30: 185-192
  • 79 Wiesmann T, Steinfeldt T, Volk T. et al. Mehr Sehen – Technische Innovationen in der Regionalanästhesie. Anaesthesist 2014; 63: 875-882