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Planta Med 2017; 83(17): 1368-1373
DOI: 10.1055/s-0043-114736
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata

Miao Dong   *
1   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
,
Li-Qiu Quan   *
1   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
,
Wei-Feng Dai
1   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
,
Shi-Li Yan
1   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
,
Chin-Ho Chen
2   Duke University Medical Center, Duke University, Durham, NC, USA
,
Xuan-Qin Chen
1   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
,
Rong-Tao Li
1   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
› Author Affiliations
Further Information

Publication History

received 07 March 2017
revised 02 June 2017

accepted 16 June 2017

Publication Date:
29 June 2017 (online)

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Abstract

Three new compounds (1 – 3), including a sesterterpenoid, aspterpenacid C (1), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones (4 – 10), were isolated from the ethanol extract of the traditional Chinese medicinal plant Swertia bimaculata. Their structures were elucidated on the basis of the methods of spectroscopic NMR, MS, and computational chemistry. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compounds 1 – 10 were tested for activities on the inhibition of nitric oxide production and HIV-1 replication in vitro. Compound 1 exhibited moderate activity in inhibiting nitric oxide production (IC50 = 16.1 µM) and HIV-1 replication (EC50 = 1.35 µM).

Key words

sesterterpenoid - Swertia bimaculata - Gentianaceae - anti-inflammation - anti-HIV

* These two authors contributed equally to this work.


Supporting Information

    HR-ESI-MS and NMR spectra of aspterpenacid C (1), (−)-swerimusaldehyde A (2), and 3,3′,5-trihydroxybiphenyl-2-ethanone (3) are available as Supporting Information.

  • Supporting Information
 

  • References

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