Dtsch Med Wochenschr 2018; 143(09): 634-642
DOI: 10.1055/s-0043-115622
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© Georg Thieme Verlag KG Stuttgart · New York

Prävention und Diagnostik multiresistenter Erreger

Prevention and Detection of Multidrug-resistant Bacteria
Simone Scheithauer
,
Martin Kaase
Further Information

Publication History

Publication Date:
23 April 2018 (online)

Abstract

Patients colonized or infected by multidrug-resistant bacteria (MDR) are entitled to the same medical treatment as other patients and infection control measures based on the current evidence are not in conflict with this aim. Recent studies indicate that the correct sampling technique is of utmost importance when screening for MRSA and usage of certain swabs might reduce the sensitivity considerably. Despite improvements in diagnostic strategies for direct MRSA detection by PCR, false positive results cannot be totally excluded. With regard to multidrug-resistant gramnegative bacteria differences between species should be emphasized to tailor infection control measures. E. g. easier transmissibility has been shown for K. pneumoniae compared to E. coli. Hospitals in Germany should strictly employ screening for carbapenemase-producing Enterobacterales as well as A. baumannii in all patients hospitalized abroad within the previous year. To avoid unnecessary social exclusion of MDR patients it must be emphasized that contact precautions are recommended for hospitals and not for long-time care facilities.

Die Besiedlung eines Patienten mit multiresistenten Erregern, die sogenannte Kolonisation, ist nicht offensichtlich erkennbar, bis die ersten Symptome auftreten. Jedoch besteht immer die Gefahr, dass die Keime auf andere Kontaktpersonen übertragen werden und diese infizieren. Um eine Verbreitung multiresistenter Keime in Krankenhäusern zu verhindern, ist eine moderne Krankenhaushygiene notwendig. Diese umfasst eine adäquate Diagnostik sowie Prävention.

 
  • Literatur

  • 1 Kommisssion für Krankenhaushygiene und Infektionsprävention (KRINKO). Empfehlungen zur Prävention und Kontrolle von Methicillin-resistenten Staphylococcus aureus-Stämmen (MRSA) in medizinischen und pflegerischen Einrichtungen. Bundesgesundheitsbl 2014; 57: 696-732
  • 2 Kommisssion für Krankenhaushygiene und Infektionsprävention (KRINKO). Hygienemaßnahmen bei Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen. Bundesgesundheitsbl 2012; 53: 1311-1354
  • 3 Becker K, van Alen S, Idelevich EA. et al. Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus . Emerg Infect Dis 2018; 24: 242-248
  • 4 Layer F, Strommenger B, Cuny C. et al. Eigenschaften, Häufigkeit und Verbreitung von MRSA in Deutschland. Epid Bull 2018; 5: 57-62
  • 5 Warnke P, Frickmann H, Ottl P. et al. Nasal screening for MRSA: different swabs-different results!. PloS One 2014; 9: e111627
  • 6 Becker K, Denis O, Roisin S. et al. Detection of mecA- and mecC-Positive Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates by the New Xpert MRSA Gen 3 PCR Assay. J Clin Microbiol 2016; 54: 180-184
  • 7 Huang SS, Septimus E, Kleinman K. et al. CDC Prevention Epicenters Program, AHRQ DECIDE Network and Healthcare-Associated Infections Program. Targeted versus universal decolonization to prevent ICU infection. N Engl J Med 2013; 368: 2255-2265
  • 8 Climo MW, Yokoe DS, Warren DK. et al. Effect of daily chlorhexidine bathing on hospital-acquired infection. N Engl J Med 2013; 368: 533-542
  • 9 Arcilla MS, van Hattem JM, Haverkate MR. et al. Import and spread of extended-spectrum β-lactamase-producing Enterobacteriaceae by international travellers (COMBAT study): a prospective, multicentre cohort study. Lancet Infect Dis 2017; 17: 78-85
  • 10 Hamprecht A, Rohde AM, Behnke M. et al. Colonization with third-generation cephalosporin-resistant Enterobacteriaceae on hospital admission: prevalence and risk factors. J Antimicrob Chemother 2016; 71: 2957-2963
  • 11 Gurieva T, Dautzenberg MJD, Gniadkowski M. et al. The Transmissibility of Antibiotic-Resistant Enterobacteriaceae in Intensive Care Units. Clin Infect Dis 2018; 66: 489-493
  • 12 Logan LK, Weinstein RA. The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace. J Infect Dis 2017; 215: S28-S36
  • 13 Kaase M, Schimanski S, Schiller R. et al. Multicentre investigation of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in German hospitals. Int J Med Microbiol 2016; 306: 415-420
  • 14 Pfennigwerth N. Bericht des Nationalen Referenzzentrums (NRZ) für gramnegative Krankenhauserreger. Epid Bull 2017; 26: 229-233
  • 15 Doi Y, Onuoha EO, Adams-Haduch JM. et al. Screening for Acinetobacter baumannii colonization by use of sponges. J Clin Microbiol 2011; 49: 154-158
  • 16 Bar-Yoseph H, Hussein K, Braun E. et al. Natural history and decolonization strategies for ESBL/carbapenem-resistant Enterobacteriaceae carriage: systematic review and meta-analysis. J Antimicrob Chemother 2016; 71: 2729-2739
  • 17 Bilinski J, Grzesiowski P, Sorensen N. et al. Fecal Microbiota Transplantation in Patients With Blood Disorders Inhibits Gut Colonization With Antibiotic-Resistant Bacteria: Results of a Prospective, Single-Center Study. Clin Infect Dis 2017; 65: 364-370
  • 18 Faron ML, Ledeboer NA, Buchan BW. Resistance Mechanisms, Epidemiology, and Approaches to Screening for Vancomycin-Resistant Enterococcus in the Health Care Setting. J Clin Microbiol 2016; 54: 2436-2447
  • 19 Klare I, Bender JK, Werner G. et al. Eigenschaften, Häufigkeit und Verbreitung von Vancomycin-resistenten Enterokokken (VRE) in Deuschland. Epid Bull 2017; 46: 519-527
  • 20 Werner G, Serr A, Schütt S. et al. Comparison of direct cultivation on a selective solid medium, polymerase chain reaction from an enrichment broth, and the BD GeneOhmTM VanR Assay for identification of vancomycin-resistant enterococci in screening specimens. Diagn Microbiol Infect Dis 2011; 70: 512-521