Ultraschnelle zelluläre Anpassung an Schwerelosigkeit

Zusammenfassung

Echtzeitmessungen auf der Internationalen Raumstation (ISS) konnten belegen, dass Zellen prinzipiell in der Lage sind, sich ultraschnell an veränderte Schwerkraftverhältnisse zu adaptieren. Im Experiment TRIPLE LUX A wurde der Einfluss von Gravitationskräften zwischen 1 und 0 g auf die Oxidative-Burst-Reaktion von NR8383-Alveolarmakrophagen untersucht. Erstmals konnte durch Echtzeit- und On-orbit-Messungen auf der ISS eine schwerkraftabhängige Reaktion in Säugerzellen direkt bewiesen und verfolgt werden. Durch den Messaufbau gelang ebenso der erstmalige Nachweis einer ultraschnellen und nach 42 Sekunden erfolgten vollständigen Anpassung einer zellulären Reaktion an die Schwerelosigkeit.

Abstract

Real-time on-orbit measurements at the International Space Station (ISS) could demonstrate that cells are in principle capable of ultimately adapting to microgravity conditions. In the experiment TRIPLE LUX A, the influence of gravitational forces between 1 and 0 g on the oxidative burst reaction of NR8383 alveolar macrophages was investigated. For the first time, a gravity-dependent reaction in mammalian cells could be directly demonstrated and followed by real-time and on-orbit measurements at the ISS. As a result of the measurement setup, the detection of a fast and complete adaptation of a cellular response to microgravity was achieved.

Key words

spaceflight - microgravity - innate immunity

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