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Horm Metab Res 2018; 50(02): 152-159
DOI: 10.1055/s-0043-120669
Endocrine Research
© Georg Thieme Verlag KG Stuttgart · New York

High Salt Intake Promotes Different Responses to Urodilatin and Uroguanylin in the Isolated Rat Kidney

Antonio Rafael Coelho Jorge
1   Superior Institute of Biomedical Sciences, Laboratory of Renal Physiology, Ceara State University, Fortaleza-CE, Brazil
,
Pedro Henrique Sá Costa
2   Institute of Biomedicine, Federal University of Ceara, Fortaleza-CE, Brazil
,
Helena Serra Azul Monteiro
2   Institute of Biomedicine, Federal University of Ceara, Fortaleza-CE, Brazil
,
Manassés Claudino Fonteles
1   Superior Institute of Biomedical Sciences, Laboratory of Renal Physiology, Ceara State University, Fortaleza-CE, Brazil
3   Universidade Presbiteriana Mackenzie, School of Pharmacy, Sao Paulo, Brazil
› Author Affiliations
Further Information

Publication History

received 28 August 2017

accepted 25 September 2017

Publication Date:
12 December 2017 (online)

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Abstract

Urodilatin (UD) and uroguanylin (UGN) have been implicated in the regulation of salt and water homeostasis, particularly in the balance handling of salt intake. In this sense, the aim of the present work was to study the main effects of these peptides in kidneys from animals subjected to high NaCl (2%) intake, during 10 days in metabolic cages. The control group received only normal water, whereas the treated group drank 2% solution of NaCl (NaCl 2%). In addition, we studied effect of subthreshold UD (0.14 nM) and UGN (0.06 μM) doses in NaCl 2% after a 30-min control period. Kidney perfusion was performed with Krebs–Henseleit containing 6 g% bovine albumin previously dialyzed. The effects of UD (0.14 nM) promoted reduction of PP, RVR, and UF in the NaCl 2% group. We also observed an increase in %TNa+ and %TCl−. The main effects of UGN in NaCl 2% were increase in PP, UF, and GFR, followed by a reduction in %TNa+ and %TCl−. After an increased intake of salt, physiological pathways are activated and regulated in order to eliminate excess sodium. In this study, we observed that in a subthreshold dose, UD does not promotes natriuresis and diuresis, suggesting that UGN is an important hormone in inducing salt excretion in a chronic salt overload. Therefore, the effects herein described may play a contributory role in the regulation of kidney function after ingestion of salty meals.

Key words

urodilatin - uroguanylin - natriuresis
 

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