Exercise Performed Concomitantly with Particulate Matter Exposure Inhibits Lung Injury

Abstract

Air pollution is a growing problem worldwide, inducing and exacerbating several diseases. Among the several components of air pollutants, particulate matter (PM), especially thick (10–2.5 µm; PM 10) and thin (≤2.5 µm; PM 2.5), are breathable particles that easily can be deposited within the lungs, resulting in pulmonary and systemic inflammation. Although physical activity is strongly recommended, its effects when practiced in polluted environments are questionable. Therefore, the present study evaluated the pulmonary and systemic response of concomitant treadmill training with PM 2.5 and PM 10 exposure. Treadmill training inhibited PM 2.5- and PM 10-induced accumulation of total leukocytes (p<0.001), neutrophils (p<0.001), macrophages (p<0.001) and lymphocytes (p<0.001) in bronchoalveolar lavage (BAL), as well as the BAL levels of IL-1beta (p<0.001), CXCL1/KC (p<0.001) and TNF-alpha (p<0.001), whereas it increased IL-10 levels (p<0.05). Similar effects were observed on accumulation of polymorphonuclear (p<0.01) and mononuclear (p<0.01) cells in the lung parenchyma and in the peribronchial space. Treadmill training also inhibited PM 2.5- and PM 10-induced systemic inflammation, as observed in the number of total leukocytes (p<0.001) and in the plasma levels of IL-1beta (p<0.001), CXCL1/KC (p<0.001) and TNF-alpha (p<0.001), whereas it increased IL-10 levels (p<0.001). Treadmill training inhibits lung and systemic inflammation induced by particulate matter.

Key words

exercise immunology - lung immunology - air pollution - particulate matter - lung inflammation

• References

• 1 Abbasi A, Vieira RP, Northoff H. Letter to the editor: The evidence of exercise-induced bronchoconstriction in endurance runners; genetic basis and gender differences. Exerc Immunol Rev 2015; 21: 186-188
• 2 Barbhaiya M, Costenbader KH. Environmental exposures and the development of systemic lupus erythematosus. Curr Opin Rheumatol 2016; 28: 497-505
• 3 Giles LV, Brandenburg JP, Carlsten C, Koehle MS. Physiological responses to diesel exhaust exposure are modified by cycling intensity. Med Sci Sports Exerc 2014; 46: 1999-2006
• 4 Harriss DJ, Atkinson G. Ethical standards in sport and exercise science research: 2016 update. Int J Sports Med 2015; 36: 1121-1124
• 5 Jacobs L, Nawrot TS, de Geus B, Meeusen R, Degraeuwe B, Bernard A, Sughis M, Nemery B, Panis LI. Subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution: An intervention study. Environ Health 2010; 9: 64
• 6 Lauzon AM, Martin JG. Airway hyperresponsiveness; Smooth muscle as the principal actor. F1000Res 2016 5. pii: F1000 Faculty Rev-306
• 7 Lee PC, Raaschou-Nielsen O, Lill CM, Bertram L, Sinsheimer JS, Hansen J, Ritz B. Gene-environment interactions linking air pollution and inflammation in Parkinson's disease. Environ Res 2016; 151: 713-720
• 8 Lü J, Liang L, Feng Y, Li R, Liu Y. Air pollution exposure and physical activity in China: Current knowledge, public health implications, and future research needs. Int J Environ Res Public Health 2015; 12: 14887-14897
• 9 Oliveira Jr MC, Greiffo FR, Rigonato-Oliveira NC, Custódio RW, Silva VR, Damaceno-Rodrigues NR, Almeida FM, Albertini R, Lopes-Martins RÁ, de Oliveira LV, de Carvalho Pde T, Ligeiro de Oliveira AP, Leal Jr EC, Vieira RP. Low level laser therapy reduces acute lung inflammation in a model of pulmonary and extrapulmonary LPS-induced ARDS. J Photochem Photobiol B 2014; 134: 57-63
• 10 Pope CA, Bhatnagar A, McCracken J, Abplanalp WT, Conklin DJ, O'Toole TE. Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation. Circ Res 2016; 119: 1204-1214
• 11 Ramos DS, Olivo CR, Quirino Santos Lopes FD, Toledo AC, Martins MA, Lazo Osório RA, Dolhnikoff M, Ribeiro W, Vieira RP. Low-intensity swimming training partially inhibits lipopolysaccharide-induced acute lung injury. Med Sci Sports Exerc 2010; 42: 113-119
• 12 Ruttens D, Verleden SE, Bijnens EM, Winckelmans E, Gottlieb J, Warnecke G, Meloni F, Morosini M, Van Der Bij W, Verschuuren EA, Sommerwerck U, Weinreich G, Kamler M, Roman A, Gomez-Olles S, Berastegui C, Benden C, Holm AM, Iversen M, Schultz HH, Luijk B, Oudijk EJ, Kwakkel-van Erp JM, Jaksch P, Klepetko W, Kneidinger N, Neurohr C, Corris P, Fisher AJ, Lordan J, Meachery G, Piloni D, Vandermeulen E, Bellon H, Hoffmann B, Vienneau D, Hoek G, de Hoogh K, Nemery B, Verleden GM, Vos R, Nawrot TS, Vanaudenaerde BM. An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe. Eur Respir J 2016; 49: 1600484
• 13 Traboulsi H, Guerrina N, Iu M, Maysinger D, Ariya P, Baglole CJ. Inhaled pollutants: The molecular scene behind respiratory and systemic diseases associated with ultrafine particulate matter. Int J Mol Sci 2017; 18 pii: E243
• 14 Vieira RP, Claudino RC, Duarte AC, Santos AB, Perini A, Faria Neto HC, Mauad T, Martins MA, Dolhnikoff M, Carvalho CR. Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice. Am J Respir Crit Care Med 2007; 176: 871-877
• 15 Vieira RP, de Andrade VF, Duarte AC, Dos Santos AB, Mauad T, Martins MA, Dolhnikoff M, Carvalho CR. Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling. Am J Physiol 2008; 295: L670-L679
• 16 Vieira RP, Toledo AC, Silva LB, Almeida FM, Damaceno-Rodrigues NR, Caldini EG, Santos AB, Rivero DH, Hizume DC, Lopes FD, Olivo CR, Castro-Faria-Neto HC, Martins MA, Saldiva PH, Dolhnikoff M. Anti-inflammatory effects of aerobic exercise in mice exposed to air pollution. Med Sci Sports Exerc 2012; 44: 1227-1234
• 17 Voliotis A, Karali I, Kouras A, Samara C. Fine and ultrafine particle doses in the respiratory tract from digital printing operations. Environ Sci Pollut Res Int 2016; 24: 3027-3037
• 18 Wong J, Magun BE, Wood LJ. Lung inflammation caused by inhaled toxicants: a review. Int J Chron Obstruct Pulmon Dis 2016; 11: 1391-1401
• 19 Zakharenko AM, Engin AB, Chernyshev VV, Chaika VV, Ugay SM, Rezaee R, Karimi G, Drozd VA, Nikitina AV, Solomennik SF, Kudryavkina OR, Xin L, Wenpeng Y, Tzatzarakis M, Tsatsakis AM, Golokhvast KS. Basophil mediated pro-allergic inflammation in vehicle-emitted particles exposure. Environ Res 2017; 152: 308-314
• 20 Zhang S, Li L, Gao W, Wang Y, Yao X. Interventions to reduce individual exposure of elderly individuals and children to haze: A review. J Thorac Dis 2016; 8: E62-E68