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Drug Res (Stuttg) 2019; 69(03): 125-129
DOI: 10.1055/s-0044-101255
Review
© Georg Thieme Verlag KG Stuttgart · New York

Are Grapes Able to Mitigate the Noxious Effects Induced by Cadmium Exposure in Different Tissues and/or Organs? A Mini Review

Bianca Andrade Handan
1   Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil
,
Caroline Margonato Cardoso
1   Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil
,
Luciana Pellegrini Pisani
1   Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil
,
Debora Estadella
1   Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil
,
Rosângela Soares Chriguer
1   Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil
,
Daniel Araki Ribeiro
1   Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil
› Author Affiliations
Further Information

Publication History

received 05 October 2017

accepted 12 January 2018

Publication Date:
15 November 2018 (online)

Also available at
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Abstract

Grapes are fruits that grow in clusters and can be crimson, black, dark blue, yellow, green, orange, and pink. Cadmium is a non-essential metal toxic to living organisms and the environment. Recently, health professionals, food scientists, and consumers have paid much attention to grapes for their health-promoting effects. To the best of our knowledge, there are no reviews describing the ability of grapes to mitigate the toxic effects induced by cadmium exposure in different tissues and/or organs. Herein, the aim of this review is to present the effects of grapes following cadmium exposure on the number of papers published in the scientific literature. The results showed that grapes are able to mitigate the harmful activities induced by exposure to cadmium in several tissues and organs. The main actions are closely related to tissue regeneration as a result of the reestablishment of morphology and antioxidant activity. However, further studies are welcomed in order to elucidate new biological pathways regarding the outcomes promoted by grapes in this context, specially related to inflammation, tissue regeneration and cellular death.

Keywords

grapes - cadmium - antioxidant activity - tissue regeneration
 

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