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Synthesis 1990; 1990(5): 427-429
DOI: 10.1055/s-1990-26896
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Studies on N,N-Disubstituted Dialkyl 2-Aminoethylphosphonates and Derivatives Thereof

Yuanyao Xu* , Xiqi Jiang, Chengye Yuan
  • *Shanghai Institute of Organic Chemistry, Academia Sinica, 345 Lingling Lu, Shanghai 200032, Peoples Republic of China
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Publication Date:
17 September 2002 (online)

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Dialkyl 2-(dialkylamino)ethylphosphonates were prepared from dialkyl 2-bromoethylphosphonates or ethenylphosphonates and secondary amines or from sodium dialkylphosphites and dialkyl(2-chloroethyl)amines. The diesters can be cleaved to the monoesters by treatment with potassium hydroxide and alcohol. The corresponding sodium salts of the monoesters are obtained by titration to neutrality with aqueous methanolic sodium hydroxide.

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