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Synthesis 1990; 1990(8): 701-702
DOI: 10.1055/s-1990-26987
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Low-Valent Titanium Induced Reductive Cyclization of Nitriles to Symmetrically Substituted Tetraalkylpyrazines

Wei-xing Chen* , Jun-hu Zhang, Ming-yang Hu, Xiao-chun Wang
  • *Department of Chemistry, Nanjing University, Nanjing, People's Republic of China
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Publication Date:
17 September 2002 (online)

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Reductive cyclization of nitriles 1 induced by titanium tetrachloride/zinc provides an efficient general synthesis of symmetrically substituted tetraalkylpyrazines 2.

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