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Synthesis 1990; 1990(8): 735-738
DOI: 10.1055/s-1990-27000
DOI: 10.1055/s-1990-27000
paper
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Hydrolysis of N-Substituted Phthalimides Using Anion Exchange Resins. Synthesis of Hydroxy-Substituted Aliphatic Primary Amines (Amino Alcohols)
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Publication History
Publication Date:
17 September 2002 (online)
N-Substituted phthalimides were successfully hydrolyzed to the corresponding hydroxy-substituted aliphatic primary amines (amino alcohols) using anion exchange resins. This method has been proved to be extremely useful for water soluble products, which are difficult to isolate.