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Synthesis 1990; 1990(10): 925-930
DOI: 10.1055/s-1990-27056
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Synthesis of (1R,4R)- and (1S,4S)-2,5-Diazabicyclo[2.2.1]heptanes and Their N-Substituted Derivatives

Ulrich Jordis* , Fritz Sauter, Suhaib M. Siddiqi, Bernhard Küenburg, Kaberi Bhattacharya
  • *Institut für Organische Chemie, Technische Universität Wien, Getreidemarkt 9, A-1060 Wien, Austria
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Publication Date:
17 September 2002 (online)

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Derivatives of the (1R,4R)- and (1S,4S)-2,5-diazabicyclo- [2.2.1]heptane ring system are prepared in enantiomerically pure form from trans-4-hydroxy-L-proline (2). The target compounds are precursors of antibacterial quinolone carboxyclic acids.

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