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Synthesis 1990; 1990(11): 1059-1061
DOI: 10.1055/s-1990-27093
DOI: 10.1055/s-1990-27093
paper
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Efficient Synthesis of α-(Hydroxymethyl) Ketones Not Available Through Aldol-Type Processes
Further Information
Publication History
Publication Date:
17 September 2002 (online)
An efficient synthesis of α-(hydroxymethyl) ketones from β-keto esters has been developed, which is experimentally simple, amenable to large scale production and provides products of high purity without resort to chromatography in most cases. The method is a useful alternative and complement to condensation processes.