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Synlett 1994; 1994(4): 235-236
DOI: 10.1055/s-1994-22807
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New Synthesis of the Streptonigrin Quinoline-5,8-quinone Moiety and Aromatic Cross-Coupling

A. Godard* , J. M. Fourquez, R. Tamion, F. Marsais, G. Quéguiner
  • *Laboratoire de Chimie Organique Fine et Hétérocyclique,URA CNRS 1429. Laboratoire de l'IRCOF. INSA de Rouen, BP08-76131 Mont-Saint-Aignan Cedex France
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Publication Date:
22 March 2002 (online)

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A new synthesis of quinoline-quinone moiety of Streptonigrin in nine steps with good overall yield (21%) is reported. The methodology involves metalation, a Heck coupling reaction, cyclization and oxidative demethylation.

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