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Synlett 1994; 1994(4): 255-256
DOI: 10.1055/s-1994-22817
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Enantioselective Epoxidation of Chromene Derivatives Using Hydrogen Peroxide as a Terminal Oxidant

Ryo Irie* , Naoki Hosoya, Tsutomu Katsuki
  • *Department of Chemistry, Faculty of Science, Kyushu University 33, Hakozaki, Higashi-ku, Fukuoka 812, Japan
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Publication Date:
22 March 2002 (online)

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Hydrogen peroxide was found to serve as an effective terminal oxidant for the salen-catalyzed asymmetric epoxidation of chromene derivatives, when N-methylimidazole was added to the reaction medium. Under the conditions, 6-acetamido-2,2-dimethyl-7-nitrochromene was converted into the corresponding epoxide of 95% ee in 98% yield.

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