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Synlett 1994; 1994(7): 482-484
DOI: 10.1055/s-1994-22896
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Cesium Fluoride Promoted Cyclization in the Synthesis of Enediyne Antibiotics1

Toshio Nishikawa* , Satoshi Shibuya, Minoru Isobe
  • *Laboratory of Organic Chemistry, School of Agricultural Sciences, Nagoya University, Chikusa, Nagoya 464-01, Japan
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Publication Date:
18 September 2002 (online)

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Intramolecular addition of silylacetylene to the aldehyde was effected to cyclize 10-membered enediyne compound with cesium fluoride in the presence of 18-crown-6 in THF. A small amount of acetonitrile improved the yield and reproducibility. The product was transformed to the enone which is a new simple. model compound of esperamicin/calicheamicin aglycon.

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